Search Results - "Seefeldt, Lance C."

Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage by Hoffman, Brian M, Lukoyanov, Dmitriy, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C

“…The vital role that nitrogenase plays in sustaining life is examined from a biomolecular perspective. Nitrogen fixation is shown to occur in lightning and the…”
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Beyond fossil fuel-driven nitrogen transformations by Chen, Jingguang G, Crooks, Richard M, Seefeldt, Lance C, Bren, Kara L, Bullock, R Morris, Darensbourg, Marcetta Y, Holland, Patrick L, Hoffman, Brian, Janik, Michael J, Jones, Anne K, Kanatzidis, Mercouri G, King, Paul, Lancaster, Kyle M, Lymar, Sergei V, Pfromm, Peter, Schneider, William F, Schrock, Richard R

“…Nitrogen is fundamental to all of life and many industrial processes. The interchange of nitrogen oxidation states in the industrial production of ammonia,…”
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Biodiesel production by simultaneous extraction and conversion of total lipids from microalgae, cyanobacteria, and wild mixed-cultures by Wahlen, Bradley D., Willis, Robert M., Seefeldt, Lance C.

“…Microalgae have been identified as a potential biodiesel feedstock due to their high lipid productivity and potential for cultivation on marginal land. One of…”
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Light-driven dinitrogen reduction catalyzed by a CdS:nitrogenase MoFe protein biohybrid by Brown, Katherine A., Harris, Derek F., Wilker, Molly B., Rasmussen, Andrew, Khadka, Nimesh, Hamby, Hayden, Keable, Stephen, Dukovic, Gordana, Peters, John W., Seefeldt, Lance C., King, Paul W.

“…The splitting of dinitrogen (N₂) and reduction to ammonia (NH₃) is a kinetically complex and energetically challenging multistep reaction. In the Haber-Bosch…”
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Mechanism of Mo-dependent nitrogenase by Seefeldt, Lance C, Hoffman, Brian M, Dean, Dennis R

“…Nitrogen-fixing bacteria catalyze the reduction of dinitrogen (N(2)) to two ammonia molecules (NH(3)), the major contribution of fixed nitrogen to the…”
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Reductive Elimination of H2 Activates Nitrogenase to Reduce the NN Triple Bond: Characterization of the E4(4H) Janus Intermediate in Wild-Type Enzyme by Lukoyanov, Dmitriy, Khadka, Nimesh, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C, Hoffman, Brian M

“…We proposed a reductive elimination/oxidative addition (re/oa) mechanism for reduction of N2 to 2NH3 by nitrogenase, based on identification of a…”
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Establishing a Thermodynamic Landscape for the Active Site of Mo-Dependent Nitrogenase by Hickey, David P, Cai, Rong, Yang, Zhi-Yong, Grunau, Katharina, Einsle, Oliver, Seefeldt, Lance C, Minteer, Shelley D

“…Nitrogenase enzymes are the only biological catalysts able to convert N2 to NH3. Molybdenum-dependent nitrogenase consists of two proteins and three…”
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Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects by Khadka, Nimesh, Milton, Ross D, Shaw, Sudipta, Lukoyanov, Dmitriy, Dean, Dennis R, Minteer, Shelley D, Raugei, Simone, Hoffman, Brian M, Seefeldt, Lance C

“…Nitrogenase catalyzes the reduction of dinitrogen (N2) to two ammonia (NH3) at its active site FeMo-cofactor through a mechanism involving reductive…”
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Electron Transfer to Nitrogenase in Different Genomic and Metabolic Backgrounds by Poudel, Saroj, Colman, Daniel R, Fixen, Kathryn R, Ledbetter, Rhesa N, Zheng, Yanning, Pence, Natasha, Seefeldt, Lance C, Peters, John W, Harwood, Caroline S, Boyd, Eric S

“…Nitrogenase catalyzes the reduction of dinitrogen (N ) using low-potential electrons from ferredoxin (Fd) or flavodoxin (Fld) through an ATP-dependent process…”
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Carbon dioxide reduction to methane and coupling with acetylene to form propylene catalyzed by remodeled nitrogenase by Yang, Zhi-Yong, Moure, Vivian R, Dean, Dennis R, Seefeldt, Lance C

“…A doubly substituted form of the nitrogenase MoFe protein (α-70 ⱽᵃˡ→ᴬˡᵃ, α-195 ᴴⁱˢ→ᴳˡⁿ) has the capacity to catalyze the reduction of carbon dioxide (CO ₂) to…”
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Kinetic Understanding of N2 Reduction versus H2 Evolution at the E4(4H) Janus State in the Three Nitrogenases by Harris, Derek F, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C, Hoffman, Brian M

“…The enzyme nitrogenase catalyzes the reduction of N2 to ammonia but also that of protons to H2. These reactions compete at the mechanistically central ‘Janus’…”
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An Experimentally Evaluated Thermodynamic Approach to Estimate Growth of Photoheterotrophic Purple Non-sulfur Bacteria by Doloman, Anna, Seefeldt, Lance C.

“…Distribution of energy during the growth and formation of useful chemicals by microorganisms can define the overall performance of a biotechnological system…”
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Electron Transfer within Nitrogenase: Evidence for a Deficit-Spending Mechanism by Danyal, Karamatullah, Dean, Dennis R, Hoffman, Brian M, Seefeldt, Lance C

“…The reduction of substrates catalyzed by nitrogenase utilizes an electron transfer (ET) chain comprised of three metalloclusters distributed between the two…”
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Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family by Garcia Costas, Amaya M, Poudel, Saroj, Miller, Anne-Frances, Schut, Gerrit J, Ledbetter, Rhesa N, Fixen, Kathryn R, Seefeldt, Lance C, Adams, Michael W W, Harwood, Caroline S, Boyd, Eric S, Peters, John W

“…Electron bifurcation is the coupling of exergonic and endergonic redox reactions to simultaneously generate (or utilize) low- and high-potential electrons. It…”
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On reversible H₂ loss upon N₂ binding to FeMo-cofactor of nitrogenase by Yang, Zhi-Yong, Khadka, Nimesh, Lukoyanov, Dmitriy, Hoffman, Brian M, Dean, Dennis R, Seefeldt, Lance C

“…Nitrogenase is activated for N ₂ reduction by the accumulation of four electrons/protons on its active site FeMo-cofactor, yielding a state, designated as E ₄,…”
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Electron transfer precedes ATP hydrolysis during nitrogenase catalysis by Duval, Simon, Danyal, Karamatullah, Shaw, Sudipta, Lytle, Anna K., Dean, Dennis R., Hoffman, Brian M., Antony, Edwin, Seefeldt, Lance C.

“…The biological reduction of N ₂ to NH ₃ catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with…”
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Characterization of a Fatty Acyl-CoA Reductase from Marinobacter aquaeolei VT8: A Bacterial Enzyme Catalyzing the Reduction of Fatty Acyl-CoA to Fatty Alcohol by Willis, Robert M, Wahlen, Bradley D, Seefeldt, Lance C, Barney, Brett M

“…Fatty alcohols are of interest as a renewable feedstock to replace petroleum compounds used as fuels, in cosmetics, and in pharmaceuticals. One biological…”
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Electrocatalytic CO2 reduction catalyzed by nitrogenase MoFe and FeFe proteins by Hu, Bo, Harris, Derek F., Dean, Dennis R., Liu, T. Leo, Yang, Zhi-Yong, Seefeldt, Lance C.

“…Nitrogenases catalyze biological dinitrogen (N2) reduction to ammonia (NH3), and also reduce a number of non-physiological substrates, including carbon dioxide…”
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Sequential and differential interaction of assembly factors during nitrogenase MoFe protein maturation by Jimenez-Vicente, Emilio, Yang, Zhi-Yong, Ray, W. Keith, Echavarri-Erasun, Carlos, Cash, Valerie L., Rubio, Luis M., Seefeldt, Lance C., Dean, Dennis R.

“…Nitrogenases reduce atmospheric nitrogen, yielding the basic inorganic molecule ammonia. The nitrogenase MoFe protein contains two cofactors, a…”
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Nitrogenase resurrection and the evolution of a singular enzymatic mechanism by Garcia, Amanda K, Harris, Derek F, Rivier, Alex J, Carruthers, Brooke M, Pinochet-Barros, Azul, Seefeldt, Lance C, Kaçar, Betül

“…The planetary biosphere is powered by a suite of key metabolic innovations that emerged early in the history of life. However, it is unknown whether life has…”
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