Search Results - "Seedhouse, C"

Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia by Bailey, G. D., Doolan, L., Baskar, A., Smith, L. C., Seedhouse, C. H.

“…Nucleophosmin is commonly both over-expressed and mutated in acute myeloid leukemia (AML). NPM1 mutations are always heterozygous. In addition, NPM1 has a…”
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DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412 by SEEDHOUSE, C. H, HUNTER, H. M, LLOYD-LEWIS, B, MASSIP, A-M, PALLIS, M, CARTER, Gl, GRUNDY, M, SHANG, S, RUSSELL, N. H

“…The presence of internal tandem duplications (ITD) mutations in the FMS-like tyrosine kinase 3 (FLT3) receptor influences the risk of relapse in acute myeloid…”
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Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia by Jawad, M, Seedhouse, C, Mony, U, Grundy, M, Russell, N H, Pallis, M

“…Relapse in acute myeloid leukaemia (AML) is considered to result from the persistence of drug-resistant leukaemic stem and progenitor cells (LSPC) within a…”
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Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment by Mony, U, Jawad, M, Seedhouse, C, Russell, N, Pallis, M

“…Relapse in acute myeloid leukaemia (AML) is mediated by survival of leukaemic stem cells following remission-induction chemotherapy. It would therefore be…”
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Caspase-8 polymorphisms result in reduced Alemtuzumab-induced T-cell apoptosis and worse survival after transplantation by Shaw, B E, Lee, F, Krishnamurthy, S, Byrne, J L, Seedhouse, C, Mayor, N P, Maldonado-Torres, H, Saudemont, A, Marsh, S G E, Madrigal, J A, Russell, N H

“…Allo-SCT using unrelated donors is a curative treatment for patients with hematological disorders. The best donor is one matched for 10/10 HLA alleles, however…”
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Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia by SEEDHOUSE, C. H, DAS-GUPTA, E. P, RUSSELL, N. H

“…The hMLH1 and hMSH2 genes are involved in the DNA mismatch repair (MMR) pathway. Defects in either of these genes have been associated with genetic instability…”
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275 Targeting XRCC1 (X-ray Repair Cross-complementing Gene 1), a Key DNA Base Excision Repair Protein for Personalized Therapy in Breast and Ovarian Cancer by Sultana, R, Abdel-Fatah, T, Albarakati, N, Abbotts, R, Seedhouse, C, Ball, G, Chan, S, Rakha, E, Ellis, I, Madhusudan, S

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PO-014 Targeting PARP1 in XRCC1 deficient sporadic invasive breast cancer or pre-invasive ductal carcinoma in situ for synthetic lethality and chemoprevention by Ali, R, Al-kawaz, A, Toss, MS, Green, A, Miligy, IA, Mesquita, K Almeida, Seedhouse, C, Mirza, S, Rakha, E, Madhusudan, S

“…IntroductionTargeting PARP1 for synthetic lethality is a novel strategy for BRCA germ-line mutated breast cancers. However, BRCA germ-line mutations are rare…”
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P009 Genetic polymorphisms of DNA-repair- and detoxification enzymes in therapy-related AML and MDS by Fischer, S, Seedhouse, C, Schulz, T, Westphal, G, Haase, D

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Anti-8-oxo-2′-deoxyguanosine Phage Antibodies: Isolation, Characterization, and Relationship to Disease States by Seedhouse, C.H., Margison, G.P., Hendry, J.H., Hajeer, A., Embleton, M.J.

“…We have used human single chain Fv (scFv) phage display antibody libraries to isolate recombinant antibodies against the DNA adduct 8-oxo-2′-deoxyguanosine…”
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Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia by Das‐Gupta, Emma P., Seedhouse, Claire H., Russell, Nigel H.

“…Using a sensitive fluorescent‐polymerase chain reaction technique we looked for microsatellite instability (MSI) as functional evidence of mismatch repair…”
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DNA repair mechanisms and acute myeloblastic leukemia by Das-Gupta, E. P., Seedhouse, C. H., Russell, N. H.

“…DNA repair mechanisms play a vital role in maintaining genomic integrity. With the wealth of knowledge gained recently on these processes it is becoming clear…”
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PS1022 PREFERENTIAL TRANSCRIPTION OF THE MUTATED ALLELE IN NPM1 MUTATED ACUTE MYELOID LEUKAEMIA by Bailey, G., Baskar, A., Smith, L., Russell, N., Seedhouse, C.

“…Background: Nucleophosmin (NPM1) is a multi‐functional protein which shuttles continually between cellular compartments. Under normal circumstances NPM1 is…”
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The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia by SEEDHOUSE, Claire, BAINTON, Rowena, LEWIS, Michael, HARDING, Alexander, RUSSELL, Nigel, DAS-GUPTA, Emma

“…Polymorphisms in several DNA repair genes have been described. These polymorphisms may affect DNA repair capacity and modulate cancer susceptibility by means…”
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PB2102 A SAME DAY ASSAY USING CYTOCHROME C RELEASE DETERMINES SENSITIVITY TO COOPERATIVE BCL‐2 AND MCL‐1 TARGETING IN MULTIPLE MYELOMA CELL LINES AND PRIMARY SAMPLES by Grundy, M., Cull, J., Al‐Kaisi, F., Williams, C., Smith, D., Seedhouse, C.

“…Background: Multiple myeloma is an incurable haematological malignancy with remarkable clonal and genetic heterogeneity. Although both MCL‐1 and BCL‐2 are…”
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Polymorphisms in Genes Involved in Homologous Recombination Repair Interact to Increase the Risk of Developing Acute Myeloid Leukemia by SEEDHOUSE, Claire, FAULKNER, Rowena, ASHRAF, Nadia, DAS-GUPTA, Emma, RUSSELL, Nigel

“…Purpose: Double-strand break repair via homologous recombination is essential in maintaining genetic integrity. RAD51 and XRCC3 are involved in the repair of…”
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The Effect of ABC Transporters and FLT3 Status on the Activity of the Aurora Kinase B Inhibitor AZD1152 in AML Cells by Grundy, Martin, Shang, Shili, Seedhouse, C., Russell, Nigel H., Pallis, Monica

“…The aurora kinases are essential for mitotic progression. Both Aurora A and B are over-expressed in a wide variety of human haematological and epithelial…”
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A caspase8 promoter polymorphism is associated with increased TRM and reduced survival following T-cell depleted unrelated donor transplantation using alemtuzumab by Krishnamurthy, S, Shaw, B.E, Byrne, J, Seedhouse, C, Mayor, N, Madrigal, J.A, Russell, N

“…The 6 nucleotide insertion-deletion polymorphism in caspase8 (CASP8) promoter is demonstrated to destroy an Sp1 binding site, resulting in reduced CASP8…”
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A Polymorphism Study on Detoxification and DNA Repair Genes in 700 MDS Patients Demonstrates An Association Between Genotype and An Aberrant Karyotype by Seedhouse, C., Fischer, Stephanie, Ganster, Christina, Fonatsch, Christa, Valent, Peter, Germing, Ulrich, Russell, Nigel H., Haase, Detlef

“…The maintenance of genetic stability within haematopoietic stem cells is essential for normal haematopoiesis and this is emphasised by the association of…”
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The Effect of the CASP8 -6526N Del Promoter Polymorphism on Outcome in T-Cell Depleted Unrelated Donor Haemopoetic Stem Cell Transplants (HSCT) by Krishnamurthy, Suchitra, Shaw, Bronwen E., Byrne, J. L, Seedhouse, C., Mayor, Neema P, Madrigal, A. J, Russell, Nigel H.

“…The 6 nucleotide insertion-deletion polymorphism (-6526N del) in the CASP8 promoter has been demonstrated to destroy an Sp1 binding site, resulting in reduced…”
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