Search Results - "Seebeck, Thomas"

MHC-Dependent Mate Preferences in Humans by Wedekind, Claus, Seebeck, Thomas, Bettens, Florence, Paepke, Alexander J.

“…One substantial benefit of sexual reproduction could be that it allows animals (including humans) to react rapidly to a continuously changing environmental…”
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The cAMP-Specific Phosphodiesterase TbPDE2C is an Essential Enzyme in Bloodstream Form Trypanosoma brucei by Zoraghi, Roya, Seebeck, Thomas

“…Chemotherapy of human sleeping sickness, a fatal disease caused by the protozoan parasite Trypanosoma brucei, is in a dismal state, and the identification and…”
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Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei by Matovu, Enock, Stewart, Mhairi L, Geiser, Federico, Brun, Reto, Mäser, Pascal, Wallace, Lynsey J M, Burchmore, Richard J, Enyaru, John C K, Barrett, Michael P, Kaminsky, Ronald, Seebeck, Thomas, de Koning, Harry P

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The N Terminus of Phosphodiesterase TbrPDEB1 of Trypanosoma brucei Contains the Signal for Integration into the Flagellar Skeleton by Luginbuehl, Edith, Ryter, Damaris, Schranz-Zumkehr, Judith, Oberholzer, Michael, Kunz, Stefan, Seebeck, Thomas

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Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei by Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas

“…Chromosome 9 of Trypanosoma brucei contains two closely spaced, very similar open reading frames for cyclic nucleotide specific phosphodiesterases TbrPDEB1 and…”
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The exopolyphosphatase TbrPPX1 of Trypanosoma brucei by Luginbuehl, Edith, Kunz, Stefan, Wentzinger, Laurent, Freimoser, Florian, Seebeck, Thomas

“…Exopolyphosphatases and pyrophosphatases play important but still incompletely understood roles in energy metabolism, and also in other aspects of cell biology…”
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Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited by Geiser, Federico, Lüscher, Alexandra, de Koning, Harry P, Seebeck, Thomas, Mäser, Pascal

“…Trypanosoma brucei are unicellular parasites that cause sleeping sickness in humans and nagana in livestock. Trypanosomes salvage purines from their hosts…”
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Cyclic nucleotide specific phosphodiesterases of Leishmania major by Johner, Andrea, Kunz, Stefan, Linder, Markus, Shakur, Yasmin, Seebeck, Thomas

“…Leishmania represent a complex of important human pathogens that belong to the systematic order of the kinetoplastida. They are transmitted between their human…”
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Characterization of TbPDE2A, a Novel Cyclic Nucleotide-specific Phosphodiesterase from the Protozoan Parasite Trypanosoma brucei by Zoraghi, Roya, Kunz, Stefan, Gong, Kewei, Seebeck, Thomas

“…This study reports the identification and characterization of a cAMP-specific phosphodiesterase from the parasitic hemoflagellate Trypanosoma brucei. TbPDE2A…”
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Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite by Seebeck, Thomas, Sterk, Geert Jan, Ke, Hengming

“…Protozoan infections remain a major unsolved medical problem in many parts of our world. A major obstacle to their treatment is the blatant lack of medication…”
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The Intensity of Human Body Odors and the MHC: Should We Expect a Link? by Wedekind, Claus, Seebeck, Thomas, Bettens, Florence, Paepke, Alexander J.

“…It is now well established that genes within the major histocompatibility complex (MHC) somehow affect the production of body odors in several vertebrates,…”
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Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei by Cristodero, Marina, Seebeck, Thomas, Schneider, André

“…The parasitic protozoa Trypanosoma brucei has a complex life cycle. Oxidative phosphorylation is highly active in the procyclic form but absent from…”
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Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets by de Koning, Harry P., Gould, Matthew K., Sterk, Geert Jan, Tenor, Hermann, Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas

“…The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with…”
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A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes by Oberholzer, Michael, Morand, Sabine, Kunz, Stefan, Seebeck, Thomas

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Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: Comparison with the Alamar Blue assay by Gould, Matthew K., Vu, Xuan Lan, Seebeck, Thomas, de Koning, Harry P.

“…The urgent need for new drug development for African trypanosomiasis is widely recognized. This requires reliable and informative high-throughput assays…”
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Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence by Oberholzer, Michael, Marti, Gabriela, Baresic, Mario, Kunz, Stefan, Hemphill, Andrew, Seebeck, Thomas

“…Cyclic nucleotide specific phosphodiesterases (PDEs) are pivotal regulators of cellular signaling. They are also important drug targets. Besides catalytic…”
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Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure by Jansen, Chimed, Wang, Huanchen, Kooistra, Albert J, de Graaf, Chris, Orrling, Kristina M, Tenor, Hermann, Seebeck, Thomas, Bailey, David, de Esch, Iwan J. P, Ke, Hengming, Leurs, Rob

“…Trypanosoma brucei cyclic nucleotide phosphodiesterase B1 (TbrPDEB1) and TbrPDEB2 have recently been validated as new therapeutic targets for human African…”
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Histidine-phosphorylation of succinyl CoA synthetase from Trypanosoma brucei by Hunger-Glaser, Isabel, Linder, Markus, Seebeck, Thomas

“…The insect form of Trypanosoma brucei depends on respiration for its energy requirements. It contains a fully functional mitochondrion with a complete citric…”
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Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells by Kuhn-Nentwig, Lucia, Willems, Jean, Seebeck, Thomas, Shalaby, Tarek, Kaiser, Marcel, Nentwig, Wolfgang

“…Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes,…”
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Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals by Veerman, Johan, van den Bergh, Toine, Orrling, Kristina M., Jansen, Chimed, Cos, Paul, Maes, Louis, Chatelain, Eric, Ioset, Jean-Robert, Edink, Ewald E., Tenor, Hermann, Seebeck, Thomas, de Esch, Iwan, Leurs, Rob, Sterk, Geert Jan

“…[Display omitted] Trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) play an important role in the life cycle of Trypanosoma brucei, the…”
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