In vivo assessment of oxidative stress, neurotoxicity and histological alterations induction in the marine gastropod Stramonita haemastoma exposed to Cr2O3 and Al2O3 nanoparticles

The increased use of nanoparticles (NPs) is expected to raise their presence in the marine ecosystem, which is considered as the final destination of released NPs. This study investigated the toxicity of Cr2O3 (42 nm) and Al2O3 (38 nm) NPs (1, 2.5, and 5 mg/L) on the digestive glands of Stramonita h...

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Bibliographic Details
Published in:	Chemosphere (Oxford) Vol. 366; p. 143434
Main Authors:	Sedrati, Fateh, Bouzahouane, Hana, Khaldi, Fadila, Menaa, Mohcen, Bouarroudj, Tayeb, Gzara, Lassaad, Zaidi, Hadjer, Bensalem, Mounira, Laouar, Omar, Sleimi, Noomene, Nasri, Hichem, Ouali, Kheireddine
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-10-2024
Subjects:	Histopathology Nanoparticles Neurotoxicity Oxidative stress Stramonita haemastoma Nanoparticles Oxidative stress Neurotoxicity Histopathology Stramonita haemastoma
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Summary:	The increased use of nanoparticles (NPs) is expected to raise their presence in the marine ecosystem, which is considered as the final destination of released NPs. This study investigated the toxicity of Cr2O3 (42 nm) and Al2O3 (38 nm) NPs (1, 2.5, and 5 mg/L) on the digestive glands of Stramonita haemastoma for 7, 14, and 28 days by oxidative stress biomarkers, neurotoxicity indicator assessment, and histological study. Results revealed an imbalance in antioxidants at all periods. Following 7 days, both NPs caused GSH depletion with marked impacts from Al2O3. GPx, CAT, and AChE were also decreased with the highest changes induced by Cr2O3. Both NPs inducted GSH and GST levels on days 14 and 28, with more effects from Cr2O3 exposure. GPx, AChE, and MDA induction were observed on day 28, while MT varied through NPs and time, with imbalanced levels at all periods noticed, SOD was mostly not affected. Histology revealed alterations including necrosis and interstitial deteriorations; quantitative analysis through the histological condition index revealed dose-dependent impacts, with the highest values attributed to Cr2O3 exposure. While PCA revealed the co-response of GSH, GST, GPx, CAT, and AchE with separated MT responses. This study reported oxidative stress induction through a multi-biomarkers investigation, neurotoxicity, and histological damages in the digestive gland of S. haemastoma following Cr2O3 and Al2O3 NPs exposure. [Display omitted] •Both nanoparticles induced oxidative stress confirmed by antioxidants imbalance.•Nps concentrations caused multiple histological alterations after 28 days.•Metallothionein seems to act separately from other antioxidants.•Both Nps induced neurotoxic effects after 7 exposure days by disturbing AChE activity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0045-6535 1879-1298 1879-1298
DOI:	10.1016/j.chemosphere.2024.143434