Search Results - "Sedo, Aleksi"

Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein by Dvořáková, Petra, Bušek, Petr, Knedlík, Tomáš, Schimer, Jiří, Etrych, Tomáš, Kostka, Libor, Stollinová Šromová, Lucie, Šubr, Vladimír, Šácha, Pavel, Šedo, Aleksi, Konvalinka, Jan

“…Proteases are directly involved in cancer pathogenesis. Expression of fibroblast activation protein (FAP) is upregulated in stromal fibroblasts in more than…”
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Regulation of Fibroblast Activation Protein by Transforming Growth Factor Beta-1 in Glioblastoma Microenvironment by Krepela, Evzen, Vanickova, Zdislava, Hrabal, Petr, Zubal, Michal, Chmielova, Barbora, Balaziova, Eva, Vymola, Petr, Matrasova, Ivana, Busek, Petr, Sedo, Aleksi

“…The proline-specific serine protease fibroblast activation protein (FAP) can participate in the progression of malignant tumors and represents a potential…”
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Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets by Busek, Petr, Hrabal, Petr, Fric, Premysl, Sedo, Aleksi

“…Fibroblast activation protein (FAP, seprase, EC 3.4.21.B28) and dipeptidyl peptidase-IV (DPP-IV, CD26, EC 3.4.14.5) are homologous serine proteases implicated…”
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Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival by Sana, Jiri, Busek, Petr, Fadrus, Pavel, Besse, Andrej, Radova, Lenka, Vecera, Marek, Reguli, Stefan, Stollinova Sromova, Lucie, Hilser, Marek, Lipina, Radim, Lakomy, Radek, Kren, Leos, Smrcka, Martin, Sedo, Aleksi, Slaby, Ondrej

“…Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant…”
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Heterogeneity of molecular forms of dipeptidyl peptidase-IV and fibroblast activation protein in human glioblastomas by Matrasova, Ivana, Busek, Petr, Balaziova, Eva, Sedo, Aleksi

“…Proteolytic enzymes contribute to the progression of various cancers. We previously reported increased expression of the proline specific peptidases dipeptidyl…”
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Fibroblast Activation Protein Expressing Mesenchymal Cells Promote Glioblastoma Angiogenesis by Balaziova, Eva, Vymola, Petr, Hrabal, Petr, Mateu, Rosana, Zubal, Michal, Tomas, Robert, Netuka, David, Kramar, Filip, Zemanova, Zuzana, Svobodova, Karla, Brabec, Marek, Sedo, Aleksi, Busek, Petr

“…Fibroblast activation protein (FAP) is a membrane-bound protease that is upregulated in a wide range of tumours and viewed as a marker of tumour-promoting…”
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Fibroblasts potentiate melanoma cells in vitro invasiveness induced by UV-irradiated keratinocytes by Jobe, Njainday Pulo, Živicová, Veronika, Mifková, Alžběta, Rösel, Daniel, Dvořánková, Barbora, Kodet, Ondřej, Strnad, Hynek, Kolář, Michal, Šedo, Aleksi, Smetana, Karel, Strnadová, Karolina, Brábek, Jan, Lacina, Lukáš

“…Melanoma represents a malignant disease with steadily increasing incidence. UV-irradiation is a recognized key factor in melanoma initiation. Therefore, the…”
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Combination of quinoxaline with pentamethinium system: Mitochondrial staining and targeting by Kejík, Zdeněk, Koubková, Nela, Krčová, Lucie, Sýkora, David, Abramenko, Nikita, Veselá, Kateřina, Kaplánek, Robert, Hajduch, Jan, Houdová Megová, Magdalena, Bušek, Petr, Šedo, Aleksi, Lacina, Lukáš, Smetana Jr, Karel, Martásek, Pavel, Jakubek, Milan

“…[Display omitted] •Quinoxaline conjugates with indolium PMS were prepared and full characterized.•Strong affinity and fluorescence response against…”
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New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity by Talianová, Veronika, Kejík, Zdeněk, Kaplánek, Robert, Veselá, Kateřina, Abramenko, Nikita, Lacina, Lukáš, Strnadová, Karolína, Dvořánková, Barbora, Martásek, Pavel, Masařík, Michal, Megová, Magdalena Houdová, Bušek, Petr, Křížová, Jana, Zdražilová, Lucie, Hansíková, Hana, Vlčák, Erik, Filimonenko, Vlada, Šedo, Aleksi, Smetana, Karel, Jakubek, Milan

“…IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R)…”
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Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells by Garcia-Borja, Elena, Siegl, Frantisek, Mateu, Rosana, Slaby, Ondrej, Sedo, Aleksi, Busek, Petr, Sana, Jiri

“…Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting…”
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Targeting fibroblast activation protein in cancer ndash Prospects and caveats by Sedo, Aleksi

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Early detection of pancreatic cancer: impact of high-resolution imaging methods and biomarkers by Frič, Přemysl, Škrha, Jan, Šedo, Aleksi, Zima, Tomaš, Bušek, Petr, Kmochová, Klára, Laclav, Martin, Bunganič, Bohuš, Solař, Svatopluk, Hrabal, Petr, Bělina, František, Záruba, Pavel, Škrha, Pavel, Zavoral, Miroslav

“…High-resolution imaging methods (HRIMs) and biomarkers present the second step of pancreatic cancer (PC) diagnostics in at-risk individuals. These include…”
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Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications by Šimková, Adéla, Bušek, Petr, Šedo, Aleksi, Konvalinka, Jan

“…Fibroblast activation protein (FAP) is a non-classical serine protease expressed predominantly in conditions accompanied by tissue remodeling, particularly…”
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Ageing as an Important Risk Factor for Cancer by Smetana, Jr, Karel, Lacina, Lukáš, Szabo, Pavol, Dvořánková, Barbora, Brož, Prokop, Šedo, Aleksi

“…An ageing population is a typical feature of many developed countries across the world. Analyzed from a biomedical and philosophical point of view, this…”
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Dipeptidyl peptidase IV activity and/or structure homologs: contributing factors in the pathogenesis of rheumatoid arthritis? by Sedo, Aleksi, Duke-Cohan, Jonathan S, Balaziova, Eva, Sedova, Liliana R

“…Several of the proinflammatory peptides involved in rheumatoid arthritis pathogenesis, including peptides induced downstream of tumor necrosis factor-alpha as…”
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Targeting fibroblast activation protein in cancer - Prospects and caveats by Busek, Petr, Mateu, Rosana, Zubal, Michal, Kotackova, Lenka, Sedo, Aleksi

“…Fibroblast activation protein (FAP, seprase) is a serine protease with post-proline dipeptidyl peptidase and endopeptidase enzymatic activity. FAP is…”
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Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation by Gál, Peter, Brábek, Jan, Holub, Michal, Jakubek, Milan, Šedo, Aleksi, Lacina, Lukáš, Strnadová, Karolína, Dubový, Petr, Hornychová, Helena, Ryška, Aleš, Smetana, Karel

“…Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe…”
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Molecularly targeted protease-activated probes for visualization of glioblastoma: a comparison with 5-ALA by Konečná, Dora, Výmola, Petr, Ternerová, Nikola, Výmolová, Barbora, Garcia-Borja, Elena, Mateu, Rosana, Šroubek, Filip, Pankrác, Jan, Widen, John C, Bogyo, Matthew, Netuka, David, Bušek, Petr, Šedo, Aleksi

“…The highly infiltrative growth of glioblastoma (GBM) makes distinction between the tumor and normal brain tissue challenging. Therefore, fluorescence-guided…”
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Microtubule-associated NAV3 regulates invasive phenotypes in glioblastoma cells by Škarková, Aneta, Pelantová, Markéta, Tolde, Ondřej, Legátová, Anna, Mateu, Rosana, Bušek, Petr, Garcia-Borja, Elena, Šedo, Aleksi, Etienne-Manneville, Sandrine, Rösel, Daniel, Brábek, Jan

“…Glioblastomas are aggressive brain tumors for which effective therapy is still lacking, resulting in dismal survival rates. These tumors display significant…”
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Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours by Zubaľ, Michal, Výmolová, Barbora, Matrasová, Ivana, Výmola, Petr, Vepřková, Jana, Syrůček, Martin, Tomáš, Robert, Vaníčková, Zdislava, Křepela, Evžen, Konečná, Dora, Bušek, Petr, Šedo, Aleksi

“…Brain metastases are a very common and serious complication of oncological diseases. Despite the vast progress in multimodality treatment, brain metastases…”
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