Search Results - "Sedlyarov, Vitaly"

LZTR1 is a regulator of RAS ubiquitination and signaling by Bigenzahn, Johannes W, Collu, Giovanna M, Kartnig, Felix, Pieraks, Melanie, Vladimer, Gregory I, Heinz, Leonhard X, Sedlyarov, Vitaly, Schischlik, Fiorella, Fauster, Astrid, Rebsamen, Manuele, Parapatics, Katja, Blomen, Vincent A, Müller, André C, Winter, Georg E, Kralovics, Robert, Brummelkamp, Thijn R, Mlodzik, Marek, Superti-Furga, Giulio

“…In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding…”
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Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import by Girardi, Enrico, Agrimi, Gennaro, Goldmann, Ulrich, Fiume, Giuseppe, Lindinger, Sabrina, Sedlyarov, Vitaly, Srndic, Ismet, Gürtl, Bettina, Agerer, Benedikt, Kartnig, Felix, Scarcia, Pasquale, Di Noia, Maria Antonietta, Liñeiro, Eva, Rebsamen, Manuele, Wiedmer, Tabea, Bergthaler, Andreas, Palmieri, Luigi, Superti-Furga, Giulio

“…About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest…”
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HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis by Lang, Michaela, Berry, David, Passecker, Katharina, Mesteri, Ildiko, Bhuju, Sabin, Ebner, Florian, Sedlyarov, Vitaly, Evstatiev, Rayko, Dammann, Kyle, Loy, Alexander, Kuzyk, Orest, Kovarik, Pavel, Khare, Vineeta, Beibel, Martin, Roma, Guglielmo, Meisner-Kober, Nicole, Gasche, Christoph

“…HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3'…”
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TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9 by Heinz, Leonhard X., Lee, JangEun, Kapoor, Utkarsh, Kartnig, Felix, Sedlyarov, Vitaly, Papakostas, Konstantinos, César-Razquin, Adrian, Essletzbichler, Patrick, Goldmann, Ulrich, Stefanovic, Adrijana, Bigenzahn, Johannes W., Scorzoni, Stefania, Pizzagalli, Mattia D., Bensimon, Ariel, Müller, André C., King, F. James, Li, Jun, Girardi, Enrico, Mbow, M. Lamine, Whitehurst, Charles E., Rebsamen, Manuele, Superti-Furga, Giulio

“…Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses 1 – 3 . Here we show that a previously…”
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A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs by Girardi, Enrico, César-Razquin, Adrián, Lindinger, Sabrina, Papakostas, Konstantinos, Konecka, Justyna, Hemmerich, Jennifer, Kickinger, Stefanie, Kartnig, Felix, Gürtl, Bettina, Klavins, Kristaps, Sedlyarov, Vitaly, Ingles-Prieto, Alvaro, Fiume, Giuseppe, Koren, Anna, Lardeau, Charles-Hugues, Kumaran Kandasamy, Richard, Kubicek, Stefan, Ecker, Gerhard F., Superti-Furga, Giulio

“…Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and are major determinants of cellular metabolism. Several SLCs have been…”
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A substrate‐based ontology for human solute carriers by Meixner, Eva, Goldmann, Ulrich, Sedlyarov, Vitaly, Scorzoni, Stefania, Rebsamen, Manuele, Girardi, Enrico, Superti‐Furga, Giulio

“…Solute carriers (SLCs) are the largest family of transmembrane transporters in the human genome with more than 400 members. Despite the fact that SLCs mediate…”
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CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response by Bancerek, Joanna, Poss, Zachary C., Steinparzer, Iris, Sedlyarov, Vitaly, Pfaffenwimmer, Thaddäus, Mikulic, Ivana, Dölken, Lars, Strobl, Birgit, Müller, Mathias, Taatjes, Dylan J., Kovarik, Pavel

“…Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine…”
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The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification by Sedlyarov, Vitaly, Eichner, Ruth, Girardi, Enrico, Essletzbichler, Patrick, Goldmann, Ulrich, Nunes-Hasler, Paula, Srndic, Ismet, Moskovskich, Anna, Heinz, Leonhard X., Kartnig, Felix, Bigenzahn, Johannes W., Rebsamen, Manuele, Kovarik, Pavel, Demaurex, Nicolas, Superti-Furga, Giulio

“…Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we…”
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Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution by Sedlyarov, Vitaly, Fallmann, Jörg, Ebner, Florian, Huemer, Jakob, Sneezum, Lucy, Ivin, Masa, Kreiner, Kristina, Tanzer, Andrea, Vogl, Claus, Hofacker, Ivo, Kovarik, Pavel

“…Precise regulation of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. However, a global model integrating…”
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The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection by Ebner, Florian, Sedlyarov, Vitaly, Tasciyan, Saren, Ivin, Masa, Kratochvill, Franz, Gratz, Nina, Kenner, Lukas, Villunger, Andreas, Sixt, Michael, Kovarik, Pavel

“…Protective responses against pathogens require a rapid mobilization of resting neutrophils and the timely removal of activated ones. Neutrophils are…”
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Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions by Sneezum, Lucy, Eislmayr, Kevin, Dworak, Helene, Sedlyarov, Vitaly, Le Heron, Anita, Ebner, Florian, Fischer, Irmgard, Iwakura, Yoichiro, Kovarik, Pavel

“…The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent…”
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Tristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation by Kratochvill, Franz, Machacek, Christian, Vogl, Claus, Ebner, Florian, Sedlyarov, Vitaly, Gruber, Andreas R, Hartweger, Harald, Vielnascher, Raimund, Karaghiosoff, Marina, Rülicke, Thomas, Müller, Mathias, Hofacker, Ivo, Lang, Roland, Kovarik, Pavel

“…For a successful yet controlled immune response, cells need to specifically destabilize inflammatory mRNAs but prevent premature removal of those still used…”
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A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs by Girardi, Enrico, César-Razquin, Adrián, Lindinger, Sabrina, Papakostas, Konstantinos, Konecka, Justyna, Hemmerich, Jennifer, Kickinger, Stefanie, Kartnig, Felix, Gürtl, Bettina, Klavins, Kristaps, Sedlyarov, Vitaly, Ingles-Prieto, Alvaro, Fiume, Giuseppe, Koren, Anna, Lardeau, Charles-Hugues, Kumaran Kandasamy, Richard, Kubicek, Stefan, Ecker, Gerhard F., Superti-Furga, Giulio

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Posttranscriptional regulation of cytokine expression by Kovarik, Pavel, Ebner, Florian, Sedlyarov, Vitaly

“…Expression of cytokines and chemokines is regulated at multiple steps during the transfer of the genetic information from DNA sequence to the functional…”
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AREsite2: an enhanced database for the comprehensive investigation of AU/GU/U-rich elements by Fallmann, Jörg, Sedlyarov, Vitaly, Tanzer, Andrea, Kovarik, Pavel, Hofacker, Ivo L

“…AREsite2 represents an update for AREsite, an on-line resource for the investigation of AU-rich elements (ARE) in human and mouse mRNA 3'UTR sequences. The new…”
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Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions by Steinparzer, Iris, Sedlyarov, Vitaly, Rubin, Jonathan D., Eislmayr, Kevin, Galbraith, Matthew D., Levandowski, Cecilia B., Vcelkova, Terezia, Sneezum, Lucy, Wascher, Florian, Amman, Fabian, Kleinova, Renata, Bender, Heather, Andrysik, Zdenek, Espinosa, Joaquin M., Superti-Furga, Giulio, Dowell, Robin D., Taatjes, Dylan J., Kovarik, Pavel

“…Transcriptional responses to external stimuli remain poorly understood. Using global nuclear run-on followed by sequencing (GRO-seq) and precision nuclear…”
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Natural RNA Polymerase Aptamers Regulate Transcription in E. coli by Sedlyarova, Nadezda, Rescheneder, Philipp, Magán, Andrés, Popitsch, Niko, Rziha, Natascha, Bilusic, Ivana, Epshtein, Vitaly, Zimmermann, Bob, Lybecker, Meghan, Sedlyarov, Vitaly, Schroeder, Renée, Nudler, Evgeny

“…In search for RNA signals that modulate transcription via direct interaction with RNA polymerase (RNAP), we deep sequenced an E. coli genomic library enriched…”
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Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions by Rebsamen, Manuele, Girardi, Enrico, Sedlyarov, Vitaly, Scorzoni, Stefania, Papakostas, Konstantinos, Vollert, Manuela, Konecka, Justyna, Guertl, Bettina, Klavins, Kristaps, Wiedmer, Tabea, Superti-Furga, Giulio

“…Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the…”
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The FAIR Cookbook - the essential resource for and by FAIR doers by Rocca-Serra, Philippe, Gu, Wei, Ioannidis, Vassilios, Abbassi-Daloii, Tooba, Capella-Gutierrez, Salvador, Chandramouliswaran, Ishwar, Splendiani, Andrea, Burdett, Tony, Giessmann, Robert T., Henderson, David, Batista, Dominique, Emam, Ibrahim, Gadiya, Yojana, Giovanni, Lucas, Willighagen, Egon, Evelo, Chris, Gray, Alasdair J. G., Gribbon, Philip, Juty, Nick, Welter, Danielle, Quast, Karsten, Peeters, Paul, Plasterer, Tom, Wood, Colin, van der Horst, Eelke, Reilly, Dorothy, van Vlijmen, Herman, Scollen, Serena, Lister, Allyson, Thurston, Milo, Granell, Ramon, Sansone, Susanna-Assunta

“…The notion that data should be Findable, Accessible, Interoperable and Reusable, according to the FAIR Principles, has become a global norm for good data…”
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A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery by Essletzbichler, Patrick, Sedlyarov, Vitaly, Frommelt, Fabian, Soulat, Didier, Heinz, Leonhard X, Stefanovic, Adrijana, Neumayer, Benedikt, Superti-Furga, Giulio

“…Phagocytosis, the process by which cells engulf large particles, plays a vital role in driving tissue clearance and host defense. Its dysregulation is…”
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