Search Results - "Sedlik, Christine"

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients by Núñez, Nicolas Gonzalo, Tosello Boari, Jimena, Ramos, Rodrigo Nalio, Richer, Wilfrid, Cagnard, Nicolas, Anderfuhren, Cyrill Dimitri, Niborski, Leticia Laura, Bigot, Jeremy, Meseure, Didier, De La Rochere, Philippe, Milder, Maud, Viel, Sophie, Loirat, Delphine, Pérol, Louis, Vincent-Salomon, Anne, Sastre-Garau, Xavier, Burkhard, Becher, Sedlik, Christine, Lantz, Olivier, Amigorena, Sebastian, Piaggio, Eliane

“…Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression,…”
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Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node by Alonso, Ruby, Flament, Héloïse, Lemoine, Sébastien, Sedlik, Christine, Bottasso, Emanuel, Péguillet, Isabel, Prémel, Virginie, Denizeau, Jordan, Salou, Marion, Darbois, Aurélie, Núñez, Nicolás Gonzalo, Salomon, Benoit, Gross, David, Piaggio, Eliane, Lantz, Olivier

“…CD4 + T cell antitumor responses have mostly been studied in transplanted tumors expressing secreted model antigens (Ags), while most mutated proteins in human…”
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Treg-targeted IL-2/anti-IL-2 complex controls graft- versus -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation by Thiolat, Allan, Pilon, Caroline, Caudana, Pamela, Moatti, Audrey, To, Nhu Hanh, Sedlik, Christine, Leclerc, Mathieu, Maury, Sébastien, Piaggio, Eliane, Cohen, José L

“…Modulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid…”
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CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas by Niborski, Leticia Laura, Gueguen, Paul, Ye, Mengliang, Thiolat, Allan, Ramos, Rodrigo Nalio, Caudana, Pamela, Denizeau, Jordan, Colombeau, Ludovic, Rodriguez, Raphaël, Goudot, Christel, Luccarini, Jean-Michel, Soudé, Anne, Bournique, Bruno, Broqua, Pierre, Pace, Luigia, Baulande, Sylvain, Sedlik, Christine, Quivy, Jean-Pierre, Almouzni, Geneviève, Cohen, José L., Zueva, Elina, Waterfall, Joshua J., Amigorena, Sebastian, Piaggio, Eliane

“…Tumor-infiltrating CD8 + T cells progressively lose functionality and fail to reject tumors. The underlying mechanism and re-programing induced by checkpoint…”
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CD74 supports accumulation and function of regulatory T cells in tumors by Bonnin, Elisa, Rodrigo Riestra, Maria, Marziali, Federico, Mena Osuna, Rafael, Denizeau, Jordan, Maurin, Mathieu, Saez, Juan Jose, Jouve, Mabel, Bonté, Pierre-Emmanuel, Richer, Wilfrid, Nevo, Fabien, Lemoine, Sebastien, Girard, Nicolas, Lefevre, Marine, Borcoman, Edith, Vincent-Salomon, Anne, Baulande, Sylvain, Moreau, Helene D., Sedlik, Christine, Hivroz, Claire, Lennon-Duménil, Ana-Maria, Tosello Boari, Jimena, Piaggio, Eliane

“…Regulatory T cells (Tregs) are plastic cells playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to the microenvironment…”
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Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer by Borcoman, Edith, De La Rochere, Philippe, Richer, Wilfrid, Vacher, Sophie, Chemlali, Walid, Krucker, Clémentine, Sirab, Nanour, Radvanyi, Francois, Allory, Yves, Pignot, Géraldine, Barry de Longchamps, Nicolas, Damotte, Diane, Meseure, Didier, Sedlik, Christine, Bieche, Ivan, Piaggio, Eliane

“…Although immune checkpoint inhibitors have shown improvement in survival in comparison to chemotherapy in urothelial bladder cancer, many patients still fail…”
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Author Correction: CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity by Xiang, Yao, Mata-Garrido, Jorge, Fu, Yuanji, Desterke, Christophe, Batsché, Eric, Hamaï, Ahmed, Sedlik, Christine, Sereme, Youssouf, Skurnik, David, Jalil, Abdelali, Onifarasoaniaina, Rachel, Frapy, Eric, Beche, Jean-Christophe, Alao, Razack, Piaggio, Eliane, Arbibe, Laurence, Chang, Yunhua

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CBX3 antagonizes IFNγ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity by Xiang, Yao, Mata-Garrido, Jorge, Fu, Yuanji, Desterke, Christophe, Batsché, Eric, Hamaï, Ahmed, Sedlik, Christine, Sereme, Youssouf, Skurnik, David, Jalil, Abdelali, Onifarasoaniaina, Rachel, Frapy, Eric, Beche, Jean-Christophe, Alao, Razack, Piaggio, Eliane, Arbibe, Laurence, Chang, Yunhua

“…As an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its dysregulation links to diverse colon pathologies, such as colitis…”
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Author Correction: CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas by Niborski, Leticia Laura, Gueguen, Paul, Ye, Mengliang, Thiolat, Allan, Ramos, Rodrigo Nalio, Caudana, Pamela, Denizeau, Jordan, Colombeau, Ludovic, Rodriguez, Raphaël, Goudot, Christel, Luccarini, Jean-Michel, Soudé, Anne, Bournique, Bruno, Broqua, Pierre, Pace, Luigia, Baulande, Sylvain, Sedlik, Christine, Quivy, Jean-Pierre, Almouzni, Geneviève, Cohen, José L., Zueva, Elina, Waterfall, Joshua J., Amigorena, Sebastian, Piaggio, Eliane

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Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes by Rethacker, Louise, Boy, Maxime, Bisio, Valeria, Roussin, France, Denizeau, Jordan, Vincent-Salomon, Anne, Borcoman, Edith, Sedlik, Christine, Piaggio, Eliane, Toubert, Antoine, Dulphy, Nicolas, Caignard, Anne

“…Innate lymphoid cells (ILCs) - which include cytotoxic Natural Killer (NK) cells and helper-type ILC - are important regulators of tissue immune homeostasis,…”
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TLR3 Activation of Intratumoral CD103 + Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity by Roselli, Emiliano, Araya, Paula, Núñez, Nicolás Gonzalo, Gatti, Gerardo, Graziano, Francesca, Sedlik, Christine, Benaroch, Philippe, Piaggio, Eliane, Maccioni, Mariana

“…An important challenge in cancer immunotherapy is to expand the number of patients that benefit from immune checkpoint inhibitors (CI), a fact that has been…”
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Polyfunctional KLRG-1 + CD57 + Senescent CD4 + T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients by Ramello, Maria C, Núñez, Nicolás G, Tosello Boari, Jimena, Bossio, Sabrina N, Canale, Fernando P, Abrate, Carolina, Ponce, Nicolas, Del Castillo, Andrés, Ledesma, Marta, Viel, Sophie, Richer, Wilfrid, Sedlik, Christine, Tiraboschi, Carolina, Muñoz, Marcos, Compagno, Daniel, Gruppi, Adriana, Acosta Rodríguez, Eva V, Piaggio, Eliane, Montes, Carolina L

“…Senescent T cells have been described during aging, chronic infections, and cancer; however, a comprehensive study of the phenotype, function, and…”
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CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade by Bossio, Sabrina N., Abrate, Carolina, Tosello Boari, Jimena, Rodriguez, Constanza, Canale, Fernando P., Ramello, María C., Brunotto, Valentina, Richer, Wilfrid, Rocha, Dario, Sedlik, Christine, Vincent-Salomon, Anne, Borcoman, Edith, Del Castillo, Andres, Gruppi, Adriana, Fernandez, Elmer, Acosta Rodríguez, Eva V., Piaggio, Eliane, Montes, Carolina L.

“…Conventional CD4 + T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood…”
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Loss of immune tolerance to IL-2 in type 1 diabetes by Pérol, Louis, Lindner, John M., Caudana, Pamela, Nunez, Nicolas Gonzalo, Baeyens, Audrey, Valle, Andrea, Sedlik, Christine, Loirat, Delphine, Boyer, Olivier, Créange, Alain, Cohen, José Laurent, Rogner, Ute Christine, Yamanouchi, Jun, Marchant, Martine, Leber, Xavier Charles, Scharenberg, Meike, Gagnerault, Marie-Claude, Mallone, Roberto, Battaglia, Manuela, Santamaria, Pere, Hartemann, Agnès, Traggiai, Elisabetta, Piaggio, Eliane

“…Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of…”
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Aberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN) by Merlotti, Antonela, Malizia, Alvaro López, Michea, Paula, Bonte, Pierre-Emmanuel, Goudot, Christel, Carregal, María Sol, Nuñez, Nicolás, Sedlik, Christine, Ceballos, Ana, Soumelis, Vassili, Amigorena, Sebastián, Geffner, Jorge, Piaggio, Eliane, Sabatte, Juan

“…Clusterin is a glycoprotein able to mediate different physiological functions such as control of complement activation, promotion of unfolded protein clearance…”
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Long-lasting cross-presentation of tumor antigen in human DC by Faure, Florence, Mantegazza, Adriana, Sadaka, Charlotte, Sedlik, Christine, Jotereau, Francine, Amigorena, Sebastian

“…DC cross-present exogenous antigens on MHC class I molecules, a process required for the onset of anti-tumor immune responses. In order to study the…”
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Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination by Ramos, Rodrigo Nalio, Tosch, Caroline, Kotsias, Fiorella, Claudepierre, Marie‐Christine, Schmitt, Doris, Remy‐Ziller, Christelle, Hoffmann, Chantal, Ricordel, Marine, Nourtier, Virginie, Farine, Isabelle, Laruelle, Laurence, Hortelano, Julie, Spring‐Giusti, Clementine, Sedlik, Christine, Le Tourneau, Christophe, Hoffmann, Caroline, Silvestre, Nathalie, Erbs, Philippe, Bendjama, Kaidre, Thioudellet, Christine, Quemeneur, Eric, Piaggio, Eliane, Rittner, Karola

“…Objective Antitumor viral vaccines, and more particularly poxviral vaccines, represent an active field for clinical development and translational research. To…”
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Antigen-Antibody Immune Complexes Empower Dendritic Cells to Efficiently Prime Specific CD8+ CTL Responses In Vivo by Schuurhuis, Danita H, Ioan-Facsinay, Andreea, Nagelkerken, Bas, van Schip, Jolien J, Sedlik, Christine, Melief, Cornelis J. M, Verbeek, J. Sjef, Ossendorp, Ferry

“…Dendritic cells (DCs) require a maturation signal to acquire efficient CTL-priming capacity. In vitro FcgammaR-mediated internalization of Ag-Ab immune…”
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In Vivo, Dendritic Cells Can Cross-Present Virus-Like Particles Using an Endosome-to-Cytosol Pathway by Moron, Victor Gabriel, Rueda, Paloma, Sedlik, Christine, Leclerc, Claude

“…Recombinant parvovirus-like particles (PPV-VLPs) are particulate exogenous Ags that induce strong CTL response in the absence of adjuvant. In the present…”
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Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms by Sedlik, Christine, Vigneron, James, Torrieri-Dramard, Lea, Pitoiset, Fabien, Denizeau, Jordan, Chesneau, Caroline, de la Rochere, Philippe, Lantz, Olivier, Thery, Clotilde, Bellier, Bertrand

“…The induction of an active immune response to control or eliminate tumours is still an unfulfilled challenge. We focused on plasmid DNA vaccines using an…”
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