Search Results - "Sedlak, Frantisek"

Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells by Slegerova, Jitka, Hajek, Miroslav, Rehor, Ivan, Sedlak, Frantisek, Stursa, Jan, Hruby, Martin, Cigler, Petr

“…Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for…”
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DDI2 protease controls embryonic development and inflammation via TCF11/NRF1 by Nedomova, Monika, Haberecht-Müller, Stefanie, Möller, Sophie, Venz, Simone, Prochazkova, Michaela, Prochazka, Jan, Sedlak, Frantisek, Chawengsaksophak, Kallayanee, Hammer, Elke, Kasparek, Petr, Adamek, Michael, Sedlacek, Radislav, Konvalinka, Jan, Krüger, Elke, Grantz Saskova, Klara

“…DDI2 is an aspartic protease that cleaves polyubiquitinated substrates. Upon proteotoxic stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1),…”
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Lipid Nanoparticles for Broad‐Spectrum Nucleic Acid Delivery by Hejdankova, Zuzana, Vanek, Vaclav, Sedlak, Frantisek, Prochazka, Jan, Diederichs, Audrey, Kereïche, Sami, Novotna, Barbora, Budesinsky, Milos, Birkus, Gabriel, Grantz Saskova, Klara, Cigler, Petr

“…Lipid nanoparticles (LNPs) are the most advanced nonviral modality for nucleic acid (NA) delivery, and have recently gained enormous attention in the fields of…”
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Daratumumab with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma patients – real world evidence analysis by Stork, Martin, Spicka, Ivan, Radocha, Jakub, Minarik, Jiri, Jelinek, Tomas, Jungova, Alexandra, Pavlicek, Petr, Pospisilova, Lenka, Sedlak, Frantisek, Straub, Jan, Pika, Tomas, Knechtova, Zdenka, Fidrichova, Anna, Boichuk, Ivanna, Sevcikova, Sabina, Maisnar, Vladimir, Hajek, Roman, Pour, Ludek

“…We performed real world evidence (RWE) analysis of daratumumab, lenalidomide and dexamethasone (Dara-Rd) versus lenalidomide and dexamethasone (Rd) treatment…”
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Inhibitor–GCPII Interaction: Selective and Robust System for Targeting Cancer Cells with Structurally Diverse Nanoparticles by Neburkova, Jitka, Sedlak, Frantisek, Zackova Suchanova, Jirina, Kostka, Libor, Sacha, Pavel, Subr, Vladimir, Etrych, Tomas, Simon, Petr, Barinkova, Jitka, Krystufek, Robin, Spanielova, Hana, Forstova, Jitka, Konvalinka, Jan, Cigler, Petr

“…Glutamate carboxypeptidase II (GCPII) is a membrane protease overexpressed by prostate cancer cells and detected in the neovasculature of most solid tumors…”
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P-159 Lenalidomide maintenance in R2-ISS stratified multiple myeloma patients - real world evidence by Radocha, Jakub, Jungova, Alexandra, Pour, Ludek, Špička, Ivan, Minarik, Jiri, Jelinek, Tomas, Jindra, Pavel, Stork, Martin, Pika, Tomas, Sedlak, Frantisek, Popkova, Tereza, Novakova, Denisa, Sykora, Michal, Pavlicek, Petr, Heindorfer, Adriana, Wrobel, Marek, Gregora, Evzen, Mikula, Peter, Obernauerova, Jarmila, Ullrychova, Jana, Stejskal, Lukas, Kessler, Petr, Maisnar, Vladimir, Hájek, Roman

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Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real‐world confirmation by Radocha, Jakub, Jelinek, Tomas, Pour, Ludek, Spicka, Ivan, Minarik, Jiri, Popkova, Tereza, Jungova, Alexandra, Pavlicek, Petr, Brozova, Lucie, Stork, Martin, Sedlak, Frantisek, Krhovska, Petra, Maisnar, Vladimir, Heindorfer, Adriana, Sykora, Michal, Wrobel, Marek, Mikula, Peter, Kessler, Petr, Ullrychova, Jana, Hajek, Roman

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Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma by Fassmannová, Dominika, Sedlák, František, Sedláček, Jindřich, Špička, Ivan, Grantz Šašková, Klára

“…Proteasome inhibitors are the backbone of multiple myeloma therapy. However, disease progression or early relapse occur due to development of resistance to the…”
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Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition by Sedlák, František, Kvasnička, Aleš, Marešová, Barbora, Brumarová, Radana, Dobešová, Dana, Dostálová, Kateřina, Šrámková, Karolína, Pehr, Martin, Šácha, Pavel, Friedecký, David, Konvalinka, Jan

“…Glutamate carboxypeptidase II (GCPII, also known as PSMA or FOLH1) is responsible for the cleavage of N-acetyl-aspartyl-glutamate (NAAG) to N-acetyl-aspartate…”
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Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog by Sivá, Monika, Svoboda, Michal, Veverka, Václav, Trempe, Jean-François, Hofmann, Kay, Kožíšek, Milan, Hexnerová, Rozálie, Sedlák, František, Belza, Jan, Brynda, Jiří, Šácha, Pavel, Hubálek, Martin, Starková, Jana, Flaisigová, Iva, Konvalinka, Jan, Šašková, Klára Grantz

“…Although Ddi1-like proteins are conserved among eukaryotes, their biological functions remain poorly characterized. Yeast Ddi1 has been implicated in cell…”
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Urine immunofixation is not necessary for CR definition in myeloma patients with complete M protein molecule by Radocha, Jakub, Jelinek, Tomas, Pour, Ludek, Spicka, Ivan, Minarik, Jiri, Beranova, Katerina, Plonkova, Hana, Jungova, Alexandra, Pavlicek, Petr, Brozova, Lucie, Adam, Zdeněk, Straub, Jan, Bacovsky, Jaroslav, Maisnar, Vladimir, Dekojova, Tereza, Heindorfer, Adriana, Sykora, Michal, Wrobel, Marek, Mikula, Peter, Stejskal, Lukas, Kessler, Petr, Ullrychova, Jana, Sedlak, Frantisek, Pika, Tomas, Hajek, Roman

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Tuning polymer–blood and polymer–cytoplasm membrane interactions by manipulating the architecture of poly(2-oxazoline) triblock copolymers by Lobaz, Volodymyr, Liščáková, Veronika, Sedlák, František, Musil, Dominik, Petrova, Svetlana Lukáš, Šeděnková, Ivana, Pánek, Jiří, Kučka, Jan, Konefał, Rafał, Tihlaříková, Eva, Neděla, Vilém, Pankrác, Jan, Šefc, Luděk, Hrubý, Martin, Šácha, Pavel, Štěpánek, Petr

“…Bioactive moieties designed to bind to cell membrane receptors benefit from coupling with polymeric carriers that have enhanced affinity to the cell membrane…”
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Iridium‐based Polymeric Multifunctional Imaging Tools for Biochemistry by Sansee, Anuson, Kostka, Libor, Marcalíková, Adéla, Kudláčová, Júlia, Sedlák, František, Kotrchová, Lenka, Šácha, Pavel, Etrych, Tomáš, Kielar, Filip

“…Herein, we report the development of a macromolecular multifunctional imaging tool for biological investigations, which is comprised of an…”
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iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties by Šácha, Pavel, Knedlík, Tomáš, Schimer, Jiří, Tykvart, Jan, Parolek, Jan, Navrátil, Václav, Dvořáková, Petra, Sedlák, František, Ulbrich, Karel, Strohalm, Jiří, Majer, Pavel, Šubr, Vladimír, Konvalinka, Jan

“…Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability,…”
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A novel PSMA/GCPII‐deficient mouse model shows enlarged seminal vesicles upon aging by Vorlová, Barbora, Sedlák, František, Kašpárek, Petr, Šrámková, Karolína, Malý, Marek, Zámečník, Josef, Šácha, Pavel, Konvalinka, Jan

“…Background Prostate‐specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is an important diagnostic and therapeutic target in…”
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Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII by Knedlík, Tomáš, Vorlová, Barbora, Navrátil, Václav, Tykvart, Jan, Sedlák, František, Vaculín, Šimon, Franěk, Miloslav, Šácha, Pavel, Konvalinka, Jan

“…Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed…”
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Glutamate carboxypeptidase II does not process amyloid‐β peptide by Sedlák, František, Šácha, Pavel, Blechová, Miroslava, B&rnezinová, Anna, Šafařík, Martin, Šebestík, Jaroslav, Konvalinka, Jan

“…The accumulation of amyloid‐β (Aβ) peptide is thought to be a major causative mechanism of Alzheimer's disease. Aβ accumulation could be caused by dysregulated…”
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iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties by Šácha, Pavel, Knedlík, Tomáš, Schimer, Jiří, Tykvart, Jan, Parolek, Jan, Navrátil, Václav, Dvořáková, Petra, Sedlák, František, Ulbrich, Karel, Strohalm, Jiří, Majer, Pavel, Šubr, Vladimír, Konvalinka, Jan

“…Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability,…”
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Polymers as tools for studying the internalization of membrane protein glutamate carboxypeptidase II by Kostka, Libor, Sedlák, František, Blažková, Kristýna, Etrych, Tomáš, Šácha, Pavel, Šubr, Vladimír, Konvalinka, Jan

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