Search Results - "Sedić, Mirela"

Sphingosine 1-Phosphate Signaling and Metabolism in Chemoprevention and Chemoresistance in Colon Cancer by Grbčić, Petra, Sedić, Mirela

“…Colorectal carcinoma (CRC) is the leading cause of cancer-related deaths worldwide. Despite advances in prevention and treatment modalities for CRC, rapidly…”
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Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1,2,3-triazole–coumarin hybrids by Kraljević, Tatjana Gazivoda, Harej, Anja, Sedić, Mirela, Pavelić, Sandra Kraljević, Stepanić, Višnja, Drenjančević, Domagoj, Talapko, Jasminka, Raić-Malić, Silvana

“…The 4-substituted 1,2,3-triazole core in designed coumarin hybrids (4–35) with diverse physicochemical properties was introduced by eco-friendly…”
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Targeting Ceramide Metabolism in Hepatocellular Carcinoma: New Points for Therapeutic Intervention by Grbčić, Petra, Car, Elitza Petkova Markova, Sedić, Mirela

“…Hepatocellular Carcinoma (HCC) is one of the greatest global health burdens because of its uncontrolled cell growth and proliferation, aggressive nature as…”
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Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs by Rahman, Sadia, Wittine, Karlo, Sedić, Mirela, Markova-Car, Elitza P

“…The circadian rhythms are an intrinsic timekeeping system that regulates numerous physiological, biochemical, and behavioral processes at intervals of…”
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Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer by Bistrović, Andrea, Krstulović, Luka, Harej, Anja, Grbčić, Petra, Sedić, Mirela, Koštrun, Sanja, Pavelić, Sandra Kraljević, Bajić, Miroslav, Raić-Malić, Silvana

“…A series of novel amidino 2-substituted benzimidazoles linked to 1,4-disubstituted 1,2,3-triazoles were synthesized by implementation of microwave and…”
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The Sphingosine Kinase 2 Inhibitor ABC294640 Restores the Sensitivity of BRAFV600E Mutant Colon Cancer Cells to Vemurafenib by Reducing AKT-Mediated Expression of Nucleophosmin and Translationally-Controlled Tumour Protein by Grbčić, Petra, Eichmann, Thomas O., Kraljević Pavelić, Sandra, Sedić, Mirela

“…Vemurafenib (PLX4032), small-molecule inhibitor of mutated BRAFV600E protein, has emerged as a potent anti-cancer agent against metastatic melanoma harboring…”
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Proteomic Profiling of BRAFV600E Mutant Colon Cancer Cells Reveals the Involvement of Nucleophosmin/c-Myc Axis in Modulating the Response and Resistance to BRAF Inhibition by Vemurafenib by Grbčić, Petra, Fučkar Čupić, Dora, Gamberi, Tania, Kraljević Pavelić, Sandra, Sedić, Mirela

“…BRAFV600E mutations are found in approximately 10% of colorectal cancer patients and are associated with worse prognosis and poor outcomes with systemic…”
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Targeting Tumour Metastasis: The Emerging Role of Nanotechnology by Visentin, Sarah, Sedić, Mirela, Pavelić, Sandra Kraljević, Pavelić, Krešimir

“…The metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an…”
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Novel pyrimidine-2,4-dione–1,2,3-triazole and furo[2,3-d]pyrimidine-2-one–1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation by Gregorić, Tomislav, Sedić, Mirela, Grbčić, Petra, Tomljenović Paravić, Andrea, Kraljević Pavelić, Sandra, Cetina, Mario, Vianello, Robert, Raić-Malić, Silvana

“…Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5–23) were successfully prepared by the copper(I)-catalyzed click…”
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Acid ceramidase inhibition sensitizes human colon cancer cells to oxaliplatin through downregulation of transglutaminase 2 and β1 integrin/FAK−mediated signalling by Klobučar, Marko, Grbčić, Petra, Pavelić, Sandra Kraljević, Jonjić, Nives, Visentin, Sarah, Sedić, Mirela

“…Acid ceramidase (ASAH1) has been implicated in the progression and chemoresistance in different cancers. Its role in colon cancer biology and response to…”
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Ezrin Inhibition Overcomes Acquired Resistance to Vemurafenib in BRAFV600E-Mutated Colon Cancer and Melanoma Cells In Vitro by Car, Iris, Dittmann, Antje, Vasieva, Olga, Bočkor, Luka, Grbčić, Petra, Piteša, Nikolina, Klobučar, Marko, Kraljević Pavelić, Sandra, Sedić, Mirela

“…Despite the advancements in targeted therapy for BRAFV600E-mutated metastatic colorectal cancer (mCRC), the development of resistance to BRAFV600E inhibition…”
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Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways by Jakopovic, Boris, Horvatić, Anita, Baranasic, Jurica, Car, Iris, Oršolić, Nada, Jakopovich, Ivan, Sedić, Mirela, Kraljević Pavelić, Sandra

“…Introduction Colorectal cancer ranks as the third most common cancer in both men and women, with approximately 35% of cases being stage IV metastatic at…”
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Bioactive Sphingolipids as Biomarkers Predictive of Disease Severity and Treatment Response in Cancer: Current Status and Translational Challenges by Sedić, Mirela, Grbčić, Petra, Pavelić, Sandra Kraljević

“…Recent translational studies in cancer have produced a wealth of evidence to support an association between sphingolipid metabolism and clinical outcomes,…”
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Amidine- and Amidoxime-Substituted Heterocycles: Synthesis, Antiproliferative Evaluations and DNA Binding by Maračić, Silvija, Grbčić, Petra, Shammugam, Suresh, Radić Stojković, Marijana, Pavelić, Krešimir, Sedić, Mirela, Kraljević Pavelić, Sandra, Raić-Malić, Silvana

“…The novel 1,2,3-triazolyl-appended N- and O-heterocycles containing amidine 4–11 and amidoxime 12–22 moiety were prepared and evaluated for their…”
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Novel Bis- and Mono-Pyrrolo[2,3-d]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation by Bistrović Popov, Andrea, Vianelo, Robert, Grbčić, Petra, Sedić, Mirela, Pavelić, Sandra Kraljević, Pavelić, Krešimir, Raić-Malić, Silvana

“…Novel symmetrical bis-pyrrolo[2,3-d]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human…”
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Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling by Grbčić, Petra, Tomljanović, Ivana, Klobučar, Marko, Kraljević Pavelić, Sandra, Lučin, Ksenija, Sedić, Mirela

“…Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related deaths globally. Although 5-Fluorouracil (5-FU) is used as the first choice…”
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Secretome Screening of BRAFV600E-Mutated Colon Cancer Cells Resistant to Vemurafenib by Car, Iris, Dittmann, Antje, Klobučar, Marko, Grbčić, Petra, Kraljević Pavelić, Sandra, Sedić, Mirela

“…Patients with metastatic colorectal cancer (mCRC) carrying BRAFV600E mutation have worse response to chemotherapy and poor prognosis. The BRAFV600E inhibitor…”
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Novel 2-Thienyl- and 2-Benzothienyl-Substituted 6-(2-Imidazolinyl)Benzothiazoles: Synthesis; in vitro Evaluation of Antitumor Effects and Assessment of Mitochondrial Toxicity by Racané, Livio, Sedić, Mirela, Ilić, Nataša, Aleksić, Maja, Pavelić, Sandra Kraljević, Karminski-Zamola, Grace

“…Differently substituted thiophenes are largely studied due to their diverse pharmacological properties, especially anticancer activity. Recent studies have…”
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Coumarin‐modified ruthenium complexes: Synthesis, characterization, and antiproliferative activity against human cancer cells by Jakopec, Silvio, Hamzic, Lejla F., Bočkor, Luka, Car, Iris, Perić, Berislav, Kirin, Srećko I., Sedić, Mirela, Raić‐Malić, Silvana

“…Among ruthenium complexes studied as anticancer metallodrugs, NKP‐1339, NAMI‐A, RM175, and RAPTA‐C have already entered clinical trials due to their potent…”
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Novel 1,2,4-triazole and imidazole derivatives of l-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations by Wittine, Karlo, Stipković Babić, Maja, Makuc, Damjan, Plavec, Janez, Kraljević Pavelić, Sandra, Sedić, Mirela, Pavelić, Krešimir, Leyssen, Pieter, Neyts, Johan, Balzarini, Jan, Mintas, Mladen

“…Several novel 1,2,4-triazole and imidazole l-ascorbic acid (1, 2, 3, 5, 6 and 9) and imino-ascorbic acid (4, 7 and 8) derivatives were prepared and evaluated…”
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