Gold nanostructure-mediated delivery of anticancer agents: Biomedical applications, reversing drug resistance, and stimuli-responsive nanocarriers

Gold nanostructure-mediated delivery of anticancer agents: Biomedical applications, reversing drug resistance, and stimuli-responsive nanocarriers

The application of nanoarchitectures in cancer therapy seems to be beneficial for the delivery of antitumor drugs. In recent years, attempts have been made to reverse drug resistance, one of the factors threatening the lives of cancer patients worldwide. Gold nanoparticles (GNPs) are metal nanostruc...

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Published in:Environmental research Vol. 225; p. 115673
Main Authors: Entezari, Maliheh, Yousef Abad, Ghazaleh Gholamiyan, Sedghi, Behnaz, Ettehadi, Reyhaneh, Asadi, Shafagh, Beiranvand, Razieh, Haratian, Negar, Karimian, Seyedeh Sara, Jebali, Ali, Khorrami, Ramin, Zandieh, Mohammad Arad, Saebfar, Hamidreza, Hushmandi, Kiavash, Salimimoghadam, Shokooh, Rashidi, Mohsen, Taheriazam, Afshin, Hashemi, Mehrdad, Ertas, Yavuz Nuri
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 15-05-2023
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Bioengineering
Cancer treatment
Chemoresistance
Drug Resistance
Gold - chemistry
Gold nanoparticles
Humans
Metal Nanoparticles - chemistry
Neoplasms - drug therapy
Synergistic therapy
Bioengineering
Cancer treatment
Gold nanoparticles
Chemoresistance
Synergistic therapy
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Summary:The application of nanoarchitectures in cancer therapy seems to be beneficial for the delivery of antitumor drugs. In recent years, attempts have been made to reverse drug resistance, one of the factors threatening the lives of cancer patients worldwide. Gold nanoparticles (GNPs) are metal nanostructures with a variety of advantageous properties, such as tunable size and shape, continuous release of chemicals, and simple surface modification. This review focuses on the application of GNPs for the delivery of chemotherapy agents in cancer therapy. Utilizing GNPs results in targeted delivery and increased intracellular accumulation. Besides, GNPs can provide a platform for the co-delivery of anticancer agents and genetic tools with chemotherapeutic compounds to exert a synergistic impact. Furthermore, GNPs can promote oxidative damage and apoptosis by triggering chemosensitivity. Due to their capacity for providing photothermal therapy, GNPs can enhance the cytotoxicity of chemotherapeutic agents against tumor cells. The pH-, redox-, and light-responsive GNPs are beneficial for drug release at the tumor site. For the selective targeting of cancer cells, surface modification of GNPs with ligands has been performed. In addition to improving cytotoxicity, GNPs can prevent the development of drug resistance in tumor cells by facilitating prolonged release and loading low concentrations of chemotherapeutics while maintaining their high antitumor activity. As described in this study, the clinical use of chemotherapeutic drug-loaded GNPs is contingent on enhancing their biocompatibility. [Display omitted]
Bibliography:ObjectType-Article-2
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ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2023.115673