Search Results - "Sedelnikova, SE"

The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures by Yip, KSP, Stillman, TJ, Britton, KL, Artymiuk, PJ, Baker, PJ, Sedelnikova, SE, Engel, PC, Pasquo, A, Chiaraluce, R, Consalvi, V, Scandurra, R, Rice, DW

“…Background: The hyperthermophile Pyrococcus furiosus is one of the most thermostable organisms known, with an optimum growth temperature of 100°C. The proteins…”
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The crystal structure and active site location of isocitrate lyase from the fungus Aspergillus nidulans by Britton, KL, Langridge, SJ, Baker, PJ, Weeradechapon, K, Sedelnikova, SE, De Lucas, JR, Rice, DW, Turner, G

“…Background: Isocitrate lyase catalyses the first committed step of the carbon-conserving glyoxylate bypass, the Mg 2+-dependent reversible cleavage of…”
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Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family by Thaw, P, Sedelnikova, S.E, Muranova, T, Wiese, S, Ayora, S, Alonso, J.C, Brinkman, A.B, Akerboom, A.P, Oost, J. van der, Rafferty, J.B

“…The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a…”
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Amplification of Bifunctional Ligands for Calmodulin from a Dynamic Combinatorial Library by Milanesi, Lilia, Hunter, Christopher A., Sedelnikova, Svetlana E., Waltho, Jonathan P.

“…A well known strategy to prepare high affinity ligands for a biological receptor is to link together low affinity ligands. DCC (dynamic combinatorial…”
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Substrate-Induced Conformational Changes in Bacillus subtilis Glutamate Racemase and Their Implications for Drug Discovery by Ruzheinikov, Sergey N., Taal, Makie A., Sedelnikova, Svetlana E., Baker, Patrick J., Rice, David W.

“…D-glutamate is an essential building block of the peptidoglycan layer in bacterial cell walls and can be synthesized from L-glutamate by glutamate racemase…”
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The crystal structures of Lactococcus lactis MG1363 Dps proteins reveal the presence of an N‐terminal helix that is required for DNA binding by Stillman, Timothy J., Upadhyay, Manisha, Norte, Valia A., Sedelnikova, Svetlana E., Carradus, Maria, Tzokov, Svetomir, Bullough, Per A., Shearman, Claire A., Gasson, Michael J., Williams, Colin H., Artymiuk, Peter J., Green, Jeffrey

“…Summary Dps proteins play a major role in the protection of bacterial DNA from damage by reactive oxygen species. Previous studies have implicated the extended…”
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Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus by Leonard, Philip M., Smits, Sander H.J., Sedelnikova, Svetlana E., Brinkman, Arie B., de Vos, Willem M., van der Oost, John, Rice, David W., Rafferty, John B.

“…The LrpA protein from the hyperthermophilic archaeon Pyrococcus furiosus belongs to the Lrp/AsnC family of transcriptional regulatory proteins, of which the…”
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Structure and Dynamics of Coxsackievirus B4 2A Proteinase, an Enyzme Involved in the Etiology of Heart Disease by BAXTER, Nicola J, ROETZER, Andreas, LIEBIG, Hans-Dieter, SEDELNIKOVA, Svetlana E, HOUNSLOW, Andrea M, SKERN, Tim, WALTHO, Jonathan P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Crystal Structure of an ADP Complex of Bacillus subtilis Pyridoxal Kinase Provides Evidence for the Parallel Emergence of Enzyme Activity During Evolution by Newman, Joseph A., Das, Sanjan K., Sedelnikova, Svetlana E., Rice, David W.

“…Pyridoxal kinase catalyses the phosphorylation of pyridoxal, pyridoxine and pyridoxamine to their 5′ phosphates and plays an important role in the pyridoxal 5′…”
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A Mechanism of Drug Action Revealed by Structural Studies of Enoyl Reductase by Baldock, Clair, Rafferty, John B., Sedelnikova, Svetlana E., Baker, Patrick J., Stuitje, Antoine R., Slabas, Antoni R., Hawkes, Timothy R., Rice, David W.

“…Enoyl reductase (ENR), an enzyme involved in fatty acid biosynthesis, is the target for antibacterial diazaborines and the front-line antituberculosis drug…”
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Substrate Specificity and Mechanism from the Structure of Pyrococcus furiosus Galactokinase by Hartley, Andrew, Glynn, Steven E., Barynin, Vladimir, Baker, Patrick J., Sedelnikova, Svetlana E., Verhees, Corné, de Geus, Daniel, van der Oost, John, Timson, David J., Reece, Richard J., Rice, David W.

“…Galactokinase (GalK) catalyses the first step of the Leloir pathway of galactose metabolism, the ATP-dependent phosphorylation of galactose to…”
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Structure and Mechanism of Imidazoleglycerol-Phosphate Dehydratase by Glynn, Steven E., Baker, Patrick J., Sedelnikova, Svetlana E., Davies, Claire L., Eadsforth, Thomas C., Levy, Colin W., Rodgers, H. Fiona, Blackburn, G. Michael, Hawkes, Timothy R., Viner, Russell, Rice, David W.

“…The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides,…”
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The Crystal Structure of Diadenosine Tetraphosphate Hydrolase from Caenorhabditis elegans in Free and Binary Complex Forms by Bailey, Scott, Sedelnikova, Svetlana E, Blackburn, G.Michael, Abdelghany, Hend M, Baker, Patrick J, McLennan, Alexander G, Rafferty, John B

“…The crystal structure of C. elegans Ap 4A hydrolase has been determined for the free enzyme and a binary complex at 2.0 Å and 1.8 Å, respectively. Ap 4A…”
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Analysis of the Structure, Substrate Specificity, and Mechanism of Squash Glycerol-3-Phosphate (1)-Acyltransferase by Turnbull, Andrew P., Rafferty, John B., Sedelnikova, Svetlana E., Slabas, Antoni R., Schierer, Ted P., Kroon, Johan T.M., Simon, J.William, Fawcett, Tony, Nishida, Ikuo, Murata, Norio, Rice, David W.

“…Background: Glycerol-3-phosphate (1)-acyltransferase(G3PAT) catalyzes the incorporation of an acyl group from either acyl-acyl carrier proteins (acylACPs) or…”
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E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition by Artymiuk, Peter J, Williams, Colin H, Stillman, Timothy J, Barynin, Vladimir V, Sedelnikova, Svetlana E, Tang, Yue, Green, Jeffrey, Guest, John R

“…The major bifunctional aconitase of Escherichia coli (AcnB) serves as either an enzymic catalyst or a mRNA-binding post-transcriptional regulator, depending on…”
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Crystal Structure of DNA Recombination Protein RuvA and a Model for Its Binding to the Holliday Junction by Rafferty, John B., Sedelnikova, Svetlana E., Hargreaves, David, Artymiuk, Peter J., Baker, Patrick J., Sharples, Gary J., Mahdi, Akeel A., Lloyd, Robert G., Rice, David W.

“…The Escherichia coli DNA binding protein RuvA acts in concert with the helicase RuvB to drive branch migration of Holliday intermediates during recombination…”
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Analysis of the Open and Closed Conformations of the GTP-binding Protein YsxC from Bacillus subtilis by Ruzheinikov, Sergey N., Das, Sanjan K., Sedelnikova, Svetlana E., Baker, Patrick J., Artymiuk, Peter J., Garcı́a-Lara, Jorge, Foster, Simon J., Rice, David W.

“…Genetic analysis has suggested that the product of the Bacillus subtilis ysxC gene is essential for survival of the microorganism and hence may represent a…”
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Crystal structure of Pyrococcus furiosus phosphoglucose isomerase. Implications for substrate binding and catalysis by Berrisford, John M, Akerboom, Jasper, Turnbull, Andrew P, de Geus, Daniel, Sedelnikova, Svetlana E, Staton, Ian, McLeod, Cameron W, Verhees, Corne H, van der Oost, John, Rice, David W, Baker, Patrick J

“…Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization between d-fructose 6-phosphate and d-glucose 6-phosphate as part of the glycolytic…”
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Expression, purification and preliminary X-ray analysis of crystals of Bacillus subtilis glutamate racemase by Taal, Makie A., Sedelnikova, Svetlana E., Ruzheinikov, Sergey N., Baker, Patrick J., Rice, David W.

“…Glutamate racemase (MurI, RacE; E.C.5.1.1.3) catalyses the cofactor‐independent conversion of l‐glutamate to d‐glutamate, an essential step in the synthesis of…”
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The Structures of Inhibitor Complexes of Pyrococcus furiosus Phosphoglucose Isomerase Provide Insights into Substrate Binding and Catalysis by Berrisford, John M., Akerboom, Jasper, Brouns, Stan, Sedelnikova, Svetlana E., Turnbull, Andrew P., van der Oost, John, Salmon, Laurent, Hardré, Renaud, Murray, Iain A., Blackburn, G. Michael, Rice, David W., Baker, Patrick J.

“…Pyrococcus furiosus phosphoglucose isomerase (PfPGI) is a metal-containing enzyme that catalyses the interconversion of glucose 6-phosphate (G6P) and fructose…”
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