Search Results - "Sedelmeier, Joerg"

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters by Lima, Fabio, Sharma, Upendra K., Grunenberg, Lars, Saha, Debasmita, Johannsen, Sandra, Sedelmeier, Joerg, Van der Eycken, Erik V., Ley, Steven V.

“…We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin‐3‐ol or 4‐dimethylaminopyridine and a photoredox…”
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Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2)-C(sp3) Cross-Couplings in Flow by Lima, Fabio, Kabeshov, Mikhail A., Tran, Duc N., Battilocchio, Claudio, Sedelmeier, Joerg, Sedelmeier, Gottfried, Schenkel, Berthold, Ley, Steven V.

“…We report herein a new method for the photoredox activation of boronic esters. Using these reagents, an efficient and high‐throughput continuous flow process…”
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A Simple Scale-up Strategy for Organolithium Chemistry in Flow Mode: From Feasibility to Kilogram Quantities by Hafner, Andreas, Filipponi, Paolo, Piccioni, Lorenzo, Meisenbach, Mark, Schenkel, Berthold, Venturoni, Francesco, Sedelmeier, Joerg

“…A platform for conducting organolithium chemistry in continuous flow mode, covering the scales from medicinal chemistry to later phase process development, is…”
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WHO Listed Small Molecule Kinase Inhibitors 2001-2017 by Sedelmeier, Gottfried, Sedelmeier, Joerg, Lightfoot, Helen

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A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters by Lima, Fabio, Sharma, Upendra K., Grunenberg, Lars, Saha, Debasmita, Johannsen, Sandra, Sedelmeier, Joerg, Van der Eycken, Erik V., Ley, Steven V.

“…We report herein the use of a dual catalytic system comprising a Lewis base catalyst such as quinuclidin‐3‐ol or 4‐dimethylaminopyridine and a photoredox…”
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Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s by Hafner, Andreas, Meisenbach, Mark, Sedelmeier, Joerg

“…The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The…”
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Dichloromethyllithium: Synthesis and Application in Continuous Flow Mode by Hafner, Andreas, Mancino, Valentina, Meisenbach, Mark, Schenkel, Berthold, Sedelmeier, Joerg

“…A simple and robust procedure for the synthesis and use of thermally unstable dichloromethyllithium in continuous flow mode is described. By utilizing…”
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Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cyclization, Chlorination, and Amination by Prieschl, Michael, Sagmeister, Peter, Moessner, Christian, Sedelmeier, Joerg, Williams, Jason D., Kappe, C. Oliver

“…A new route to the cannabinoid receptor type 2 agonist, RG7774, has been developed circumventing an alkylation with poor regioselectivity as the final step. In…”
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KMnO4-Mediated Oxidation as a Continuous Flow Process by Sedelmeier, Jörg, Ley, Steven V, Baxendale, Ian R, Baumann, Marcus

“…An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids and nitroalkane derivatives to the corresponding carbonyls and…”
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Intensified Continuous Flow Synthesis and Workup of 1,5-Disubstituted Tetrazoles Enhanced by Real-Time Process Analytics by Sagmeister, Peter, Kaldre, Dainis, Sedelmeier, Joerg, Moessner, Christian, Püntener, Kurt, Kummli, Dominique, Williams, Jason D., Kappe, C. Oliver

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Biocatalyst Immobilization and Process Intensification: Production of (S)‑Piperazine-2-carboxylic Acid Dihydrochloride by Roura Padrosa, David, Wetzl, Dennis, Hildbrand, Stefan, Tosatti, Paolo, Sedelmeier, Joerg, Puentener, Kurt, Iding, Hans, Paradisi, Francesca

“…Biocatalysis, the use of enzymes to produce chemicals, offers numerous advantages over traditional organic chemistry. The most important ones are the excellent…”
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Synthesis of Vildagliptin Utilizing Continuous Flow and Batch Technologies by Pellegatti, Laurent, Sedelmeier, Jörg

“…The preparation and utilization of the Vilsmeier reagent (VR) is well-known in the literature with its usefulness and scope being frequently demonstrated in…”
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Rediscovering Cyanogen Gas for Organic Synthesis: Formation of 2‑Cyanothiazole Derivatives by Prieschl, Michael, Sedelmeier, Joerg, Püntener, Kurt, Hildbrand, Stefan, Williams, Jason D., Kappe, C. Oliver

“…The expeditious synthesis of an API building block, 2-cyanothiazole, from cyanogen gas and a readily available dithiane is reported. A previously undisclosed…”
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Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3 + 2] Cycloaddition by Sagmeister, Peter, Prieschl, Michael, Kaldre, Dainis, Gadiyar, Chethana, Moessner, Christian, Sedelmeier, Joerg, Williams, Jason D., Kappe, C. Oliver

“…We report the use of continuous flow processing to enable the first two steps of a new route toward a cannabinoid receptor type 2 agonist, RG7774. First, an…”
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Evolution of Small Molecule Kinase Drugs by Lightfoot, Helen L, Goldberg, Frederick W, Sedelmeier, Joerg

“…The development of small molecule kinase drugs is a rapidly evolving field and represents one of the most important research areas within oncology. This…”
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Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry by Kelly, Sean M., Lebl, René, Malig, Thomas C., Bass, Thomas M., Kummli, Dominique, Kaldre, Dainis, Orcel, Ugo, Tröndlin, Lars, Linder, David, Sedelmeier, Joerg, Bachmann, Stephan, Han, Chong, Zhang, Haiming, Gosselin, Francis

“…The development of a scalable continuous flow process to synthesize a densely functionalized quinazoline organozinc intermediate toward KRAS G12C inhibitor…”
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Continuous Flow as Enabling Technology: Synthesis of Heteroaromatic Sulfinates as Bench Stable Cross-Coupling Partners by Lima, Fabio, André, Jérôme, Marziale, Alexander, Greb, Andreas, Glowienke, Susanne, Meisenbach, Mark, Schenkel, Berthold, Martin, Benjamin, Sedelmeier, Joerg

“…An enabling continuous flow setup for handling of unstable organolithium intermediates and synthesis of heteroaryl sulfinates on a multigram scale is…”
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Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process by Lebl, René, Bachmann, Stephan, Tosatti, Paolo, Sedelmeier, Joerg, Püntener, Kurt, Williams, Jason D, Kappe, C. Oliver

“…Catalytic static mixer (CSM) technology is presented as an industrially viable solution for aromatic nitro group reduction in the synthesis of fenebrutinib…”
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Match-Making Reactors to Chemistry: A Continuous Manufacturing-Enabled Sequence to a Key Benzoxazole Pharmaceutical Intermediate by Susanne, Flavien, Martin, Benjamin, Aubry, Michel, Sedelmeier, Joerg, Lima, Fabio, Sevinc, Serbuelent, Piccioni, Lorenzo, Haber, Julien, Schenkel, Berthold, Venturoni, Francesco

“…The focus of this study was to develop a chemical reaction sequence toward a key benzoxazole building block, required for clinical manufacturing of a lead…”
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A Multistep Flow Process for the Synthesis of Highly Functionalized Benzoxazoles by Sedelmeier, Jörg, Lima, Fabio, Litzler, Alain, Martin, Benjamin, Venturoni, Francesco

“…An efficient and scalable transformation of 3-halo-N-acyl anilines to the corresponding benzoxazoles within a continuous flow reactor is reported. This…”
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