Search Results - "Sedel, Frédéric"

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis by Sedel, Frédéric, Bernard, Delphine, Mock, Donald M., Tourbah, Ayman

“…Progressive multiple sclerosis (MS) is a severely disabling neurological condition, and an effective treatment is urgently needed. Recently, high-dose biotin…”
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A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression by Bernard, Delphine, Prasanth, Kannanganattu V, Tripathi, Vidisha, Colasse, Sabrina, Nakamura, Tetsuya, Xuan, Zhenyu, Zhang, Michael Q, Sedel, Frédéric, Jourdren, Laurent, Coulpier, Fanny, Triller, Antoine, Spector, David L, Bessis, Alain

“…A growing number of long nuclear‐retained non‐coding RNAs (ncRNAs) have recently been described. However, few functions have been elucidated for these ncRNAs…”
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Reply to the letter: Biotinidase deficiency masquerading as multiple sclerosis? by Tourbah, Ayman, Sedel, Frédéric

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MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study by Tourbah, Ayman, Lebrun-Frenay, Christine, Edan, Gilles, Clanet, Michel, Papeix, Caroline, Vukusic, Sandra, De Sèze, Jerome, Debouverie, Marc, Gout, Olivier, Clavelou, Pierre, Defer, Gilles, Laplaud, David-Axel, Moreau, Thibault, Labauge, Pierre, Brochet, Bruno, Sedel, Frédéric, Pelletier, Jean

“…Background: Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. Objective: To…”
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Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy by Weiss, Nicolas, Barbier Saint Hilaire, Pierre, Colsch, Benoit, Isnard, Foucauld, Attala, Suleiman, Schaefer, Augustin, Amador, Maria del Mar, Rudler, Marika, Lamari, Foudil, Sedel, Frédéric, Thabut, Dominique, Junot, Christophe

“…Graphical abstract…”
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Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial by Haïk, Stéphane, MD, Marcon, Gabriella, MD, Mallet, Alain, Prof, Tettamanti, Mauro, PhD, Welaratne, Arlette, Giaccone, Giorgio, MD, Azimi, Shohreh, BSc, Pietrini, Vladimiro, MD, Fabreguettes, Jean-Roch, PharmD, Imperiale, Daniele, MD, Cesaro, Pierre, Prof, Buffa, Carlo, MD, Aucan, Christophe, PhD, Lucca, Ugo, MSc, Peckeu, Laurène, MSc, Suardi, Silvia, PhD, Tranchant, Christine, Prof, Zerr, Inga, Prof, Houillier, Caroline, MD, Redaelli, Veronica, MD, Vespignani, Hervé, Prof, Campanella, Angela, BSN, Sellal, François, MD, Krasnianski, Anna, MD, Seilhean, Danielle, Prof, Heinemann, Uta, MD, Sedel, Frédéric, MD, Canovi, Mara, PhD, Gobbi, Marco, PhD, Di Fede, Giuseppe, MD, Laplanche, Jean-Louis, Prof, Pocchiari, Maurizio, MD, Salmona, Mario, PhD, Forloni, Gianluigi, PhD, Brandel, Jean-Philippe, MD, Tagliavini, Fabrizio, Dr

“…Summary Background Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion encephalopathy. Previous studies showed that doxycycline is effective in…”
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High doses of biotin in chronic progressive multiple sclerosis: A pilot study by Sedel, Frédéric, Papeix, Caroline, Bellanger, Agnès, Touitou, Valérie, Lebrun-Frenay, Christine, Galanaud, Damien, Gout, Olivier, Lyon-Caen, Olivier, Tourbah, Ayman

“…Abstract Background No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases…”
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Reply to Letter to the Editor: Biotin supplementation in MS clinically valuable but can alter multiple blood test results by Siddiqui U, et al by Tourbah, Ayman, Sedel, Frédéric

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High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study by Créange, Alain, Hutin, Emilie, Sedel, Frédéric, Le Vigouroux, Ludivine, Lefaucheur, Jean-Pascal

“…Abstract Background We proposed to investigate high-dose pharmaceutical-grade biotin in a population of demyelinating neuropathies of different aetiologies, as…”
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MetaboRank: network-based recommendation system to interpret and enrich metabolomics results by Frainay, Clément, Aros, Sandrine, Chazalviel, Maxime, Garcia, Thomas, Vinson, Florence, Weiss, Nicolas, Colsch, Benoit, Sedel, Frédéric, Thabut, Dominique, Junot, Christophe, Jourdan, Fabien

“…Abstract Motivation Metabolomics has shown great potential to improve the understanding of complex diseases, potentially leading to therapeutic target…”
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Psychiatric manifestations of treatable hereditary metabolic disorders in adults by Demily, Caroline, Sedel, Frédéric

“…Detecting psychiatric disorders of secondary origin is a crucial concern for the psychiatrist. But how can this reliably be done among a large number of…”
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High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo by Levy, Marion J F, Garcia-Diaz, Beatriz, Sedel, Frédéric, Baron-Van Evercooren, Anne, Mozafari, Sabah

“…Accumulating evidences suggest a strong correlation between metabolic changes and neurodegeneration in CNS demyelinating diseases such as multiple sclerosis…”
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Krabbe disease in adults: phenotypic and genotypic update from a series of 11 cases and a review by Debs, Rabab, Froissart, Roseline, Aubourg, Patrick, Papeix, Caroline, Douillard, Claire, Degos, Bertrand, Fontaine, Bertrand, Audoin, Bertrand, Lacour, Arnaud, Said, Gérard, Vanier, Marie T., Sedel, Frédéric

“…Krabbe disease usually presents as a severe leukodystrophy in early infancy and childhood. From a series of 11 patients and 30 cases previously reported in the…”
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The French Gaucher's disease registry: clinical characteristics, complications and treatment of 562 patients by Stirnemann, Jérôme, Vigan, Marie, Hamroun, Dalil, Heraoui, Djazia, Rossi-Semerano, Linda, Berger, Marc G, Rose, Christian, Camou, Fabrice, de Roux-Serratrice, Christine, Grosbois, Bernard, Kaminsky, Pierre, Robert, Alain, Caillaud, Catherine, Froissart, Roselyne, Levade, Thierry, Masseau, Agathe, Mignot, Cyril, Sedel, Frédéric, Dobbelaere, Dries, Vanier, Marie T, Valayanopoulos, Vassili, Fain, Olivier, Fantin, Bruno, de Villemeur, Thierry Billette, Mentré, France, Belmatoug, Nadia

“…Clinical features, complications and treatments of Gaucher's disease (GD), a rare autosomal-recessive disorder due to a confirmed lysosomal enzyme…”
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Natural history of cerebrotendinous xanthomatosis: a paediatric disease diagnosed in adulthood by Degos, Bertrand, Nadjar, Yann, Amador, Maria del Mar, Lamari, Foudil, Sedel, Frédéric, Roze, Emmanuel, Couvert, Philippe, Mochel, Fanny

“…Cerebrotendinous xanthomatosis (CTX) is among the few inherited neurometabolic disorders amenable to specific treatment. It is easily diagnosed using plasma…”
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Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings by Mochel, Fanny, Schiffmann, Raphael, Steenweg, Marjan E., Akman, Hasan O., Wallace, Mary, Sedel, Frédéric, Laforêt, Pascal, Levy, Richard, Powers, J. Michael, Demeret, Sophie, Maisonobe, Thierry, Froissart, Roseline, Da Nobrega, Bruno Barcelos, Fogel, Brent L., Natowicz, Marvin R., Lubetzki, Catherine, Durr, Alexandra, Brice, Alexis, Rosenmann, Hanna, Barash, Varda, Kakhlon, Or, Gomori, J. Moshe, van der Knaap, Marjo S., Lossos, Alexander

“…Objective: Adult polyglucosan body disease (APBD) is an autosomal recessive leukodystrophy characterized by neurogenic bladder, progressive spastic gait, and…”
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Recommendations on the diagnosis and management of Niemann-Pick disease type C by Wraith, James E., Baumgartner, Matthias R., Bembi, Bruno, Covanis, Athanasios, Levade, Thierry, Mengel, Eugen, Pineda, Mercè, Sedel, Frédéric, Topçu, Meral, Vanier, Marie T., Widner, Hakan, Wijburg, Frits A., Patterson, Marc C.

“…Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired intracellular lipid trafficking leads to excess storage of cholesterol and…”
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MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study by Tourbah, Ayman, Gout, Olivier, Vighetto, Alain, Deburghgraeve, Véronique, Pelletier, Jean, Papeix, Caroline, Lebrun-Frenay, Christine, Labauge, Pierre, Brassat, David, Toosy, Ahmed, Laplaud, David-Axel, Outteryck, Olivier, Moreau, Thibault, Debouverie, Marc, Clavelou, Pierre, Heinzlef, Olivier, De Sèze, Jérôme, Defer, Gilles, Sedel, Frédéric, Arndt, Carl

“…Background Chronic visual loss is a disabling feature in patients with multiple sclerosis (MS). It was recently shown that MD1003 (high-dose…”
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Evolution of structural neuroimaging biomarkers in a series of adult patients with Niemann-Pick type C under treatment by Masingue, Marion, Adanyeguh, Isaac, Nadjar, Yann, Sedel, Frédéric, Galanaud, Damien, Mochel, Fanny

“…Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by a wide clinical spectrum and non-specific conventional magnetic resonance…”
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Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition by Masingue, Marion, Benoist, Jean-François, Roze, Emmanuel, Moussa, Fathi, Sedel, Frédéric, Lubetzki, Catherine, Nadjar, Yann

“…AbstractObjectiveTo describe the phenotype and the response to folinic acid supplementation of cerebral folate deficiency (CFD) in adults, a disorder diagnosed…”
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