Search Results - "Seddon, James A"

Global burden of drug-resistant tuberculosis in children: a mathematical modelling study by Dodd, Peter J, Dr, Sismanidis, Charalambos, PhD, Seddon, James A, PhD

“…Summary Background After infection with Mycobacterium tuberculosis , children are at an increased risk of progression to tuberculosis disease; a condition that…”
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Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study by Dodd, Peter J, Dr, Gardiner, Elizabeth, MSc, Coghlan, Renia, MPH, Seddon, James A, PhD

“…Summary Background Confirmation of a diagnosis of tuberculosis in children (aged <15 years) is challenging; under-reporting can result even when children do…”
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Vulnerable Children With Presumptive Tuberculosis: When Will This Population Be Prioritized? by Cruz, Andrea T, Seddon, James A

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The global burden of tuberculosis mortality in children: a mathematical modelling study by Dodd, Peter J, Yuen, Courtney M, Sismanidis, Charalambos, Seddon, James A, Jenkins, Helen E

“…Tuberculosis in children is increasingly recognised as an important component of the global tuberculosis burden, with an estimated 1 million cases in 2015…”
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The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis ? by Seddon, James A, Chiang, Silvia S, Esmail, Hanif, Coussens, Anna K

“…In high burden settings, the risk of infection with increases throughout childhood due to cumulative exposure. However, the risk of progressing from…”
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Turning off the tap: stopping tuberculosis transmission through active case-finding and prompt effective treatment by Yuen, Courtney M, PhD, Amanullah, Farhana, MD, Dharmadhikari, Ashwin, MD, Nardell, Edward A, MD, Seddon, James A, PhD, Vasilyeva, Irina, Prof, Zhao, Yanlin, PhD, Keshavjee, Salmaan, MD, Becerra, Mercedes C, Dr

“…Summary To halt the global tuberculosis epidemic, transmission must be stopped to prevent new infections and new cases. Identification of individuals with…”
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Pharmaceutical cost dynamics for the treatment of rifampicin-resistant tuberculosis in children and adolescents in South Africa, India, and the Philippines by Wilkinson, Thomas, Garcia-Prats, Anthony J, Sachs, Tina, Paradkar, Mandar, Suryavanshi, Nishi, Kinikar, Aarti, Frias, Melchor V, Sinanovic, Edina, Hesseling, Anneke C, Seddon, James A, Palmer, Megan

“…Rifampicin-resistant (RR) tuberculosis (TB) in children is a major global health concern but is often neglected in economics research. Accurate cost…”
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Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis by Ettehad, Dena, BSc, Schaaf, H Simon, MD, Seddon, James A, MBBS, Cooke, Graham S, DPhil, Ford, Nathan, Dr

“…Summary Background Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all…”
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The global impact of household contact management for children on multidrug-resistant and rifampicin-resistant tuberculosis cases, deaths, and health-system costs in 2019: a modelling study by Dodd, Peter J, Mafirakureva, Nyashadzaishe, Seddon, James A, McQuaid, Christopher F

“…Estimates suggest that at least 30 000 children develop multidrug-resistant or rifampicin-resistant tuberculosis each year. Despite household contact…”
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Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward by Olbrich, Laura, Stockdale, Lisa, Basu Roy, Robindra, Song, Rinn, Cicin-Sain, Luka, Whittaker, Elizabeth, Prendergast, Andrew J, Fletcher, Helen, Seddon, James A

“…Over 1 million children develop tuberculosis (TB) each year, with a quarter dying. Multiple factors impact the risk of a child being exposed to Mycobacterium…”
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Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis by Achar, Jay, Hewison, Cathy, Cavalheiro, Ana P, Skrahina, Alena, Cajazeiro, Junia, Nargiza, Parpieva, Herboczek, Krzysztof, Rajabov, Assliddin S, Hughes, Jennifer, Ferlazzo, Gabriella, Seddon, James A, du Cros, Philipp

“…We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good…”
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Mortality during tuberculosis treatment in South Africa using an 8-year analysis of the national tuberculosis treatment register by Osman, Muhammad, van Schalkwyk, Cari, Naidoo, Pren, Seddon, James A., Dunbar, Rory, Dlamini, Sicelo S., Welte, Alex, Hesseling, Anneke C., Claassens, Mareli M.

“…In 2011, the South African HIV treatment eligibility criteria were expanded to allow all tuberculosis (TB) patients lifelong ART. The impact of this change on…”
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SARS-CoV-2 infection and pulmonary tuberculosis in children and adolescents: a case-control study by Swanepoel, Jeremi, van der Zalm, Marieke M, Preiser, Wolfgang, van Zyl, Gert, Whittaker, Elizabeth, Hesseling, Anneke C, Moore, David A J, Seddon, James A

“…The Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic has had an impact on the global tuberculosis (TB) epidemic but evidence on the…”
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Paediatric tuberculosis – new advances to close persistent gaps by Marais, Ben J., Verkuijl, Sabine, Casenghi, Martina, Triasih, Rina, Hesseling, Anneke C., Mandalakas, Anna M., Marcy, Olivier, Seddon, James A., Graham, Stephen M., Amanullah, Farhana

“…•Children are over-represented among TB deaths; most dying without accessing TB care.•Major gaps persist in TB preventive treatment (TPT) provision and TB case…”
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Serum and cerebrospinal fluid host proteins indicate stroke in children with tuberculous meningitis by Manyelo, Charles M, Chegou, Novel N, Seddon, James A, Snyders, Candice I, Mutavhatsindi, Hygon, Manngo, Portia M, Walzl, Gerhard, Stanley, Kim, Solomons, Regan S

“…Stroke is a common complication in children with tuberculous meningitis (TBM). Host proteins may give us insight into the mechanisms of stroke in TBM and serve…”
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Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study by Dodd, Peter J, Yuen, Courtney M, Becerra, Mercedes C, Revill, Paul, Jenkins, Helen E, Seddon, James A

“…Tuberculosis is recognised as a major cause of morbidity and mortality in children, with most cases in children going undiagnosed and resulting in poor…”
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Practical and psychosocial challenges faced by caregivers influence the acceptability of multidrug-resistant tuberculosis preventive therapy for young children by Wademan, Dillon T, Hoddinott, Graeme, Purchase, Susan E, Seddon, James A, Hesseling, Anneke C, Garcia-Prats, Anthony J, Reis, Ria, Reynolds, Lindsey J

“…Drug-resistant (DR) strains of Mycobacterium tuberculosis (M. tb) are increasingly recognised as a threat to global tuberculosis (TB) control efforts…”
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Preventing tuberculosis in children: A global health emergency by Reuter, Anja, Seddon, James A., Marais, Ben J., Furin, Jennifer

“…It is estimated that 20 million children are exposed to tuberculosis (TB) each year, making TB a global paediatric health emergency. TB preventative efforts…”
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Association between clinical and environmental factors and the gut microbiota profiles in young South African children by Nel Van Zyl, Kristien, Whitelaw, Andrew C., Hesseling, Anneke C., Seddon, James A., Demers, Anne-Marie, Newton-Foot, Mae

“…Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe…”
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Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability by Huynh, Julie, Abo, Yara-Natalie, du Preez, Karen, Solomons, Regan, Dooley, Kelly E, Seddon, James A

“…Tuberculous meningitis disproportionately affects young children. As the most devastating form of tuberculosis, it is associated with unacceptably high rates…”
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