Search Results - "Secrest, R J"

Selective estrogen receptor modulators: mechanism of action and clinical experience. Focus on raloxifene by Thiebaud, D, Secrest, R J

“…Selective estrogen receptor modulators (SERMs) are a diverse group of compounds that bind with specific, high-affinity binding to the estrogen receptor (ER)…”
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Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate by Secrest, R J, Lucaites, V L, Mendelsohn, L G, Cohen, M L

“…In an effort to characterize serotonergic receptor activation in rat stomach fundus, the potential role of protein kinases, more specifically protein kinase C…”
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Comparison of contractions to serotonin, carbamylcholine and prostaglandin F2 alpha in rat stomach fundus by Secrest, R J, Schoepp, D D, Cohen, M L

“…Contractile effects of serotonin were compared to those of carbamylcholine and prostaglandin (PG) F2 alpha in an effort to characterize serotonergic receptor…”
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Role of endothelium in responses of isolated hepatic vessels to vasoactive agents by Joshi, S N, Lonigro, A J, Secrest, R J, Chapnick, B M

“…The role of the endothelium as a participant in the responses to vasoactive agents was evaluated in isolated canine hepatic artery (HA) and portal vein (PV)…”
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Endothelin: differential effects in vascular and nonvascular smooth muscle by Secrest, R J, Cohen, M L

“…Endothelin, a potent vasoconstrictor, produced concentration-dependent contractions in aorta, trachea and bladder body obtained from rat and rabbit…”
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Leukotriene D4 Relaxes Canine Renal and Superior Mesenteric Arteries by Secrest, Roberta J, Olsen, Eric J, Chapnick, Barry M

“…To characterize the influences of leukotriene D4 on regional vascular smooth muscle, effects of leukotriene D4 on vasomotor tone of canine renal and superior…”
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Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis by Gordon, Kenneth B, Blauvelt, Andrew, Papp, Kim A, Langley, Richard G, Luger, Thomas, Ohtsuki, Mamitaro, Reich, Kristian, Amato, David, Ball, Susan G, Braun, Daniel K, Cameron, Gregory S, Erickson, Janelle, Konrad, Robert J, Muram, Talia M, Nickoloff, Brian J, Osuntokun, Olawale O, Secrest, Roberta J, Zhao, Fangyi, Mallbris, Lotus, Leonardi, Craig L

“…In three phase 3 trials, ixekizumab, an anti–IL-17A monoclonal antibody, was effective in the treatment of patients with moderate-to-severe plaque psoriasis…”
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Relationship between LTD4-induced endothelium-dependent vasomotor relaxation and cGMP by Secrest, R J, Ohlstein, E H, Chapnick, B M

“…The objective of the present investigation was to determine whether cyclic GMP (cGMP) participated in endothelium-dependent leukotriene (LT) D4-induced…”
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Endothelial-Dependent Relaxation Induced by Leukotrienes C4, D4, and E4 in Isolated Canine Arteries by Secrest, Roberta J, Chapnick, Barry M

“…Leukotriene D4 has been shown to possess the capacity to relax canine superior mesenteric and renal arterial rings in an endothelial-dependent manner. The…”
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Hypotensive properties of the protein kinase inhibitor, staurosporine, in normotensive and spontaneously hypertensive rats by Secrest, R J, Williams, P, Bonjouklian, R, Modlin, D, Firman, K, Turk, J, Cohen, M L

“…The protein kinase inhibitor, staurosporine, was examined for hemodynamic actions in conscious rats and for its effects on isolated vascular smooth muscle. In…”
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Continuing Outcomes Relevant to Evista: Breast Cancer Incidence in Postmenopausal Osteoporotic Women in a Randomized Trial of Raloxifene by Martino, Silvana, Cauley, Jane A., Barrett-Connor, Elizabeth, Powles, Trevor J., Mershon, John, Disch, Damon, Secrest, Roberta J., Cummings, Steven R.

“…Background: The randomized, double-blind Multiple Outcomes of Raloxifene Evaluation (MORE) trial found that 4 years of raloxifene therapy decreased the…”
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A new approach to teaching differential diagnosis of oral soft tissue pathosis by Halstead, C L, Sparks, S M, Weathers, D R, Secrest, R J

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Effect of raloxifene on the risk of new vertebral fracture in postmenopausal women with osteopenia or osteoporosis: a reanalysis of the multiple outcomes of Raloxifene Evaluation trial by Kanis, John A, Johnell, Olof, Black, Dennis M, Downs, Robert W, Sarkar, Somnath, Fuerst, Thomas, Secrest, Roberta J, Pavo, Imre

“…Raloxifene reduces vertebral fracture risk in postmenopausal women with osteoporosis and established osteoporosis, but its efficacy in women with osteopenia…”
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Incidence of invasive breast cancer following 8 years of raloxifene therapy in postmenopausal women with osteoporosis: Results from the Continuing Outcomes Relevant to Evista (CORE) trial by Martino, S., Cauley, J. A., Barrett-Connor, E., Powles, T. J., Mershon, J. L., Disch, D., Secrest, R. J., Cummings, S. R.

“…Abstract only…”
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Effect of raloxifene on invasive breast cancer incidence in postmenopausal women stratified by Gail risk assessment: Results of the Continuing Outcomes Relevant to Evista (CORE) trial by Cauley, J. A., Martino, S., Barrett-Connor, E., Powles, T. J., Mershon, J. L., Disch, D., Secrest, R. J., Cummings, S. R.

“…Abstract only…”
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Incidence of invasive breast cancer following 8 years of raloxifene therapy in postmenopausal women with osteoporosis: Results from the Continuing Outcomes Relevant to Evista (CORE) trial by Martino, S., Cauley, J. A., Barrett-Connor, E., Powles, T. J., Mershon, J. L., Disch, D., Secrest, R. J., Cummings, S. R.

“…Abstract only…”
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Effect of raloxifene on invasive breast cancer incidence in postmenopausal women stratified by Gail risk assessment: Results of the Continuing Outcomes Relevant to Evista (CORE) trial by Cauley, J. A., Martino, S., Barrett-Connor, E., Powles, T. J., Mershon, J. L., Disch, D., Secrest, R. J., Cummings, S. R.

“…Abstract only…”
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Effect of raloxifene on the risk of new vertebral fracture in postmenopausal women with osteopenia or osteoporosis: a reanalysis of the multiple outcomes of Raloxifene Evaluation trial super(1) by Kanis, JA, Johnell, O, Black, D M, Downs, RW Jr, Sarkar, S, Fuerst, T, Secrest, R J, Pavo, I

“…Raloxifene reduces vertebral fracture risk in postmenopausal women with osteoporosis and established osteoporosis, but its efficacy in women with osteopenia…”
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RESPONSE: Re: Continuing Outcomes Relevant to Evista: Breast Cancer Incidence in Postmenopausal Osteoporotic Women in a Randomized Trial of Raloxifene by Martino, Silvana, Cauley, Jane A., Barrett-Connor, Elizabeth, Powles, Trevor J., Mershon, John, Disch, Damon, Secrest, Roberta J., Cummings, Steven R.

“…Martino et al. respond to the comments of Yalcin et al. concerning their article that stated that raloxifene treatment reduces the incidence of estrogen…”
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The Role of Selective Estrogen Receptor Modulators in the Prevention of Breast Cancer: Comparison of the Clinical Trials by Martino, Silvana, Costantino, Joseph, McNabb, Michelle, Mershon, John, Bryant, Katherine, Powles, Trevor, Secrest, Roberta J.

“…Learning Objectives After completing this course, the reader will be able to: Discuss the tamoxifen breast cancer prevention trials and the general…”
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