The effect of pravastatin and atorvastatin on coenzyme Q10

Background Coenzyme Q10 (CoQ10) is an antioxidant and plays an important role in the synthesis of adenosine triphosphate. Studies suggest that 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase inhibitors reduce CoQ10 levels; however, no studies have directly compared HMG-CoA reductase inhibi...

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Bibliographic Details
Published in:	The American heart journal Vol. 142; no. 2; pp. 13A - 18A
Main Authors:	Bleske, Barry E., Willis, Richard A., Anthony, Mark, Casselberry, Nicole, Datwani, Meeta, Uhley, Virginia E., Secontine, Stephanie G., Shea, Michael J.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01-08-2001 Elsevier
Subjects:	Biological and medical sciences Hormones. Endocrine system Medical sciences Pharmacology. Drug treatments Ubiquinone Atorvastatin Enzyme inhibitor Antioxidant Pravastatin Biological activity Antilipemic agent
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Summary:	Background Coenzyme Q10 (CoQ10) is an antioxidant and plays an important role in the synthesis of adenosine triphosphate. Studies suggest that 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase inhibitors reduce CoQ10 levels; however, no studies have directly compared HMG-CoA reductase inhibitors in a randomized crossover fashion. Methods Twelve healthy volunteers received either 20 mg pravastatin (P) or 10 mg atorvastatin (A) for 4 weeks in a randomized crossover fashion. There was a 4- to 8-week washout period between the 2 phases. CoQ10 levels and a lipid profile were obtained. Results There was no difference in CoQ10 levels from baseline to post–drug therapy for either P or A (0.61 ± 0.14 vs 0.62 ± 0.2 μg/mL and 0.65 ± 0.22 vs 0.6 ± 0.12 μg/mL, respectively; P >.05). There was a significant difference in low-density lipoprotein (LDL) levels from baseline to post–drug therapy for both P and A (97 ± 21 vs 66 ± 19 mg/dL and 102 ± 21 vs 52 ± 14 mg/dL, respectively; P <.01). There was no significant correlation between LDL and CoQ10. Conclusions P and A did not decrease CoQ10 despite a significant decrease in LDL levels. These findings suggest that HMG-CoA reductase inhibitors do not significantly decrease the synthesis of circulating CoQ10 in healthy subjects. Routine supplementation of CoQ10 may not be necessary when HMG-CoA reductase inhibitor therapy is administered. (Am Heart J 2001;142:e2.)
ISSN:	0002-8703 1097-6744
DOI:	10.1067/mhj.2001.116762