Search Results - "Secombes, Christopher J."

The cytokine networks of adaptive immunity in fish by Wang, Tiehui, Secombes, Christopher J.

“…Cytokines, produced at the site of entry of a pathogen, drive inflammatory signals that regulate the capacity of resident and newly arrived phagocytes to…”
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The Function of Fish Cytokines by Zou, Jun, Secombes, Christopher J

“…What is known about the biological activity of fish cytokines is reviewed. Most of the functional studies performed to date have been in teleost fish, and have…”
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Environmental and physiological factors shape the gut microbiota of Atlantic salmon parr (Salmo salar L.) by Dehler, Carola E., Secombes, Christopher J., Martin, Samuel A.M.

“…Gut microbes are key players in host immune system priming, protection and development, as well as providing nutrients to the host that would be otherwise…”
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Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture by Wangkahart, Eakapol, Secombes, Christopher J, Wang, Tiehui

“…Immunostimulants and vaccines are important for controlling infectious diseases in fish aquaculture. In this study we assess the potential of flagellin to be…”
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Seawater transfer alters the intestinal microbiota profiles of Atlantic salmon (Salmo salar L.) by Dehler, Carola E., Secombes, Christopher J., Martin, Samuel A. M.

“…Atlantic salmon undergo dramatic physiological changes as they migrate from freshwater to the marine environment. Osmoregulatory adaptation is the most crucial…”
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Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss) by Chang, Mingxian, Collet, Bertrand, Nie, Pin, Lester, Katherine, Campbell, Scott, Secombes, Christopher J, Zou, Jun

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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High-throughput proteomic profiling of the fish liver following bacterial infection by Causey, Dwight R, Pohl, Moritz A N, Stead, David A, Martin, Samuel A M, Secombes, Christopher J, Macqueen, Daniel J

“…High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout…”
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Discovery of All Three Types in Cartilaginous Fishes Enables Phylogenetic Resolution of the Origins and Evolution of Interferons by Redmond, Anthony K, Zou, Jun, Secombes, Christopher J, Macqueen, Daniel J, Dooley, Helen

“…Interferons orchestrate host antiviral responses in jawed vertebrates. They are categorized into three classes; IFN1 and IFN3 are the primary antiviral…”
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First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio) by Yoon, Sohye, Mitra, Suman, Wyse, Cathy, Alnabulsi, Ayham, Zou, Jun, Weerdenburg, Eveline M, van der Sar, Astrid M, Wang, Difei, Secombes, Christopher J, Bird, Steve

“…Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and…”
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Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional Characterization of Two Divergent IL2 Paralogs in Salmonids by Wang, Tiehui, Hu, Yehfang, Wangkahart, Eakapol, Liu, Fuguo, Wang, Alex, Zahran, Eman, Maisey, Kevin R, Liu, Min, Xu, Qiaoqing, Imarai, Mónica, Secombes, Christopher J

“…Mammalian interleukin (IL)-2 is a cytokine centrally involved in the differentiation and survival of CD4+ T helper subsets and CD4+ T regulatory cells and in…”
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Starvation alters the liver transcriptome of the innate immune response in Atlantic salmon (Salmo salar) by Martin, Samuel A M, Douglas, Alex, Houlihan, Dominic F, Secombes, Christopher J

“…The immune response is an energy demanding process, which has effects in many physiological pathways in the body including protein and lipid metabolism. During…”
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Cloning and Characterization of Rainbow Trout Interleukin-17A/F2 (IL-17A/F2) and IL-17 Receptor A: Expression during Infection and Bioactivity of Recombinant IL-17A/F2 by Monte, Milena M, Wang, Tiehui, Holland, Jason W, Zou, Jun, Secombes, Christopher J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: Effects on macrophage growth and antimicrobial peptide gene expression by Costa, Maria M., Maehr, Tanja, Diaz-Rosales, Patricia, Secombes, Christopher J., Wang, Tiehui

“…► The function of a fish IL-6 is studied for the first time in rainbow trout. ► Trout IL-6 expression is induced by LPS, polyI:C, IL-1β and IL-6 itself. ►…”
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Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon by Król, Elżbieta, Douglas, Alex, Tocher, Douglas R, Crampton, Viv O, Speakman, John R, Secombes, Christopher J, Martin, Samuel A M

“…The potential for alternative plant protein sources to replace limited marine ingredients in fish feeds is important for the future of the fish farming…”
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STAT3/SOCS3 axis contributes to the outcome of salmonid whirling disease by Saleh, Mona, Friedl, Adina, Srivastava, Mitaly, Soliman, Hatem, Secombes, Christopher J, El-Matbouli, Mansour

“…There are differences in disease susceptibility to whirling disease (WD) among strains of rainbow trout. The North American strain Trout Lodge (TL) is highly…”
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The Peculiar Characteristics of Fish Type I Interferons by Boudinot, Pierre, Langevin, Christelle, Secombes, Christopher J, Levraud, Jean-Pierre

“…Antiviral type I interferons (IFNs) have been discovered in fish. Genomic studies revealed their considerable number in many species; some genes encode…”
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Salmonids have an extraordinary complex type I IFN system: characterization of the IFN locus in rainbow trout oncorhynchus mykiss reveals two novel IFN subgroups by Zou, Jun, Gorgoglione, Bartolomeo, Taylor, Nicholas G H, Summathed, Thitiya, Lee, Po-Tsang, Panigrahi, Akshaya, Genet, Carine, Chen, Young-Mao, Chen, Tzong-Yueh, Ul Hassan, Mahmood, Mughal, Sharif M, Boudinot, Pierre, Secombes, Christopher J

“…Fish type I IFNs are classified into two groups with two (group I) or four (group II) cysteines in the mature peptide and can be further divided into four…”
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Which Th pathway is involved during late stage amoebic gill disease? by Benedicenti, Ottavia, Collins, Catherine, Wang, Tiehui, McCarthy, Una, Secombes, Christopher J.

“…Amoebic gill disease (AGD) is an emerging disease in North European Atlantic salmon (Salmo salar Linnaeus 1758) aquaculture caused by the amoeba Paramoeba…”
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First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities by Wang, Tiehui, Johansson, Petronella, Abós, Beatriz, Holt, Amy, Tafalla, Carolina, Jiang, Youshen, Wang, Alex, Xu, Qiaoqing, Qi, Zhitao, Huang, Wenshu, Costa, Maria M, Diaz-Rosales, Patricia, Holland, Jason W, Secombes, Christopher J

“…IL-4 and IL-13 are closely related canonical type-2 cytokines in mammals and have overlapping bioactivities via shared receptors. They are frequently activated…”
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Selenium Supplementation in Fish: A Combined Chemical and Biomolecular Study to Understand Sel-Plex Assimilation and Impact on Selenoproteome Expression in Rainbow Trout (Oncorhynchus mykiss) by Pacitti, Davide, Lawan, Muhammad M, Sweetman, John, Martin, Samuel A M, Feldmann, Jörg, Secombes, Christopher J

“…Selenium (Se) is an essential oligonutrient, as a component of several Se-containing proteins (selenoproteins), which exert important biological functions…”
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