Search Results - "Secker, Genevieve A"

Regulation of VEGFR Signalling in Lymphatic Vascular Development and Disease: An Update by Secker, Genevieve A., Harvey, Natasha L.

“…The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining recognition; lymphatic vessel dysfunction is a feature of disorders…”
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VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels by Secker, Genevieve A., Harvey, Natasha L.

“…Lymphatic vessels are an integral component of the cardiovascular system, serving important roles in fluid homeostasis, lipid absorption, and immune cell…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
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GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
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Transplantation of Ex Vivo Cultured Limbal Epithelial Stem Cells: A Review of Techniques and Clinical Results by Shortt, Alex J., MSc, MRCOphth, Secker, Genevieve A., BSc, Notara, Maria D., PhD, Limb, G. Astrid, PhD, Khaw, Peng T., PhD, FRCOphth, Tuft, Stephen J., MD, FRCOphth, Daniels, Julie T., PhD

“…Abstract Ex vivo cultured limbal epithelial stem cells have been used successfully to treat corneal limbal stem cell deficiency. We identified 17 reports of…”
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Characterization of the Limbal Epithelial Stem Cell Niche: Novel Imaging Techniques Permit In Vivo Observation and Targeted Biopsy of Limbal Epithelial Stem Cells by Shortt, Alex J., Secker, Genevieve A., Munro, Peter M., Khaw, Peng T., Tuft, Stephen J., Daniels, Julie T.

“…It is anticipated that stem cell (SC) therapy will enable the regeneration of diseased tissues and organs. Understanding SC niches is an essential step toward…”
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Ex Vivo Expansion and Transplantation of Limbal Epithelial Stem Cells by Shortt, Alex J., MSc, MRCOphth, Secker, Genevieve A., BSc, Rajan, Madhavan S., MD, FRCOphth, Meligonis, George, FCPath, Dart, John K., DM, FRCOphth, Tuft, Stephen J., MD, FRCOphth, Daniels, Julie T., PhD

“…Objective To determine, using objective measures, the outcome of ex vivo cultured limbal epithelial stem cell (LESC) transplantation performed in compliance…”
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Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice by François, Mathias, Short, Kieran, Secker, Genevieve A., Combes, Alexander, Schwarz, Quenten, Davidson, Tara-Lynne, Smyth, Ian, Hong, Young-Kwon, Harvey, Natasha L., Koopman, Peter

“…During lymphangiogenesis in the mammalian embryo, a subset of vascular endothelial cells in the cardinal veins is reprogrammed to adopt a lymphatic endothelial…”
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Three‐Year Outcomes of Cultured Limbal Epithelial Allografts in Aniridia and Stevens‐Johnson Syndrome Evaluated Using the Clinical Outcome Assessment in Surgical Trials Assessment Tool by Shortt, Alex J., Bunce, Catey, Levis, Hannah J., Blows, Peter, Doré, Caroline J., Vernon, Amanda, Secker, Genevieve A., Tuft, Stephen J., Daniels, Julie T.

“…This paper reports on the design and testing of a tool for assessing the degree of stem cell failure on the surface of the eye. This tool monitors treatment…”
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In vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis by Kazenwadel, Jan, Secker, Genevieve A, Betterman, Kelly L, Harvey, Natasha L

“…Despite the importance of blood vessels and lymphatic vessels during development and disease, the signalling pathways underpinning vessel construction remain…”
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Corneal Epithelial Stem Cells: Deficiency and Regulation by Secker, Genevieve A., Daniels, Julie T.

“…The corneal epithelium is continuously renewed by a population of stem cells that reside in the corneoscleral junction, otherwise known as the limbus. These…”
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MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels by Zhou, Zijing, Ma, Xiaonuo, Lin, Yiechang, Cheng, Delfine, Bavi, Navid, Secker, Genevieve A., Li, Jinyuan Vero, Janbandhu, Vaibhao, Sutton, Drew L., Scott, Hamish S., Yao, Mingxi, Harvey, Richard P., Harvey, Natasha L., Corry, Ben, Zhang, Yixiao, Cox, Charles D.

“…Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing…”
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Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature by Kazenwadel, Jan, Secker, Genevieve A., Liu, Yajuan J., Rosenfeld, Jill A., Wildin, Robert S., Cuellar-Rodriguez, Jennifer, Hsu, Amy P., Dyack, Sarah, Fernandez, Conrad V., Chong, Chan-Eng, Babic, Milena, Bardy, Peter G., Shimamura, Akiko, Zhang, Michael Y., Walsh, Tom, Holland, Steven M., Hickstein, Dennis D., Horwitz, Marshall S., Hahn, Christopher N., Scott, Hamish S., Harvey, Natasha L.

“…Recent work has established that heterozygous germline GATA2 mutations predispose carriers to familial myelodysplastic syndrome (MDS)/acute myeloid leukemia…”
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The Effect of Therapeutic Human Serum Drops on Corneal Stromal Wound-Healing Activity by Watson, Stephanie L., Secker, Genevieve A., Daniels, Julie T.

“…Purpose: To investigate the effect of human serum, an ocular therapy, on human corneal fibroblast (HCF) wound-healing activities. Methods: The water soluble…”
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The effect of amniotic membrane preparation method on its ability to serve as a substrate for the ex-vivo expansion of limbal epithelial cells by Shortt, Alex J, Secker, Genevieve A, Lomas, Richard J, Wilshaw, Stacy P, Kearney, John N, Tuft, Stephen J, Daniels, Julie T

“…Abstract Human amniotic membrane (HAM) is employed as a substrate for the ex-vivo expansion of limbal epithelial cells (LECs) used to treat corneal epithelial…”
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TGFβ stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling by Secker, Genevieve A., Shortt, Alex J., Sampson, Edith, Schwarz, Quenten P., Schultz, Gregory S., Daniels, Julie T.

“…The complex mechanisms by which transforming growth factor β (TGFβ) regulate re-epithelialisation following injury of stratified epithelia are not fully…”
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Stem cell therapy delivery: treading the regulatory tightrope by Daniels, Julie T, Secker, Genevieve A, Shortt, Alex J, Tuft, Stephen J, Seetharaman, Shankar

“…The concept of stem cell therapy has engaged the attention of the public and scientists alike. Intensive research effort is focused upon understanding the…”
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CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3 by KOCHETKOVA, Marina, MCKENZIE, Olivia L. D, O'CALLAGHAN, Nathan J, CLETON-JANSEN, Anne-Marie, CORNELISSE, Cees, WHITMORE, Scott A, CRAWFORD, Joanna, KREMMIDIOTIS, Gabriel, SUTHERLAND, Grant R, CALLEN, David F, BAIS, Anthony J, MARTIN, Julie M, SECKER, Genevieve A, SESHADRI, Ram, POWELL, Jason A, HINZE, Susan J, GARDNER, Alison E, SPENDLOVE, Hayley E

“…Numerous cytogenetic and molecular studies of breast cancer have identified frequent loss of heterozygosity (LOH) of the long arm of human chromosome 16. On…”
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Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow by Betterman, Kelly L, Sutton, Drew L, Secker, Genevieve A, Kazenwadel, Jan, Oszmiana, Anna, Lim, Lillian, Miura, Naoyuki, Sorokin, Lydia, Hogan, Benjamin M, Kahn, Mark L, McNeill, Helen, Harvey, Natasha L

“…The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are cell context dependent. The…”
Get full text

GATA2 is required for lymphatic vessel valve development and maintenance by Kazenwadel, Jan, Betterman, Kelly L, Chong, Chan-Eng, Stokes, Philippa H, Lee, Young K, Secker, Genevieve A, Agalarov, Yan, Demir, Cansaran Saygili, Lawrence, David M, Sutton, Drew L, Tabruyn, Sebastien P, Miura, Naoyuki, Salminen, Marjo, Petrova, Tatiana V, Matthews, Jacqueline M, Hahn, Christopher N, Scott, Hamish S, Harvey, Natasha L

“…Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently been shown to underlie a range of clinical phenotypes, including…”
Get full text