Search Results - "Seborova, Karolina"

The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes by Seborova, Karolina, Kloudova-Spalenkova, Alzbeta, Koucka, Kamila, Holy, Petr, Ehrlichova, Marie, Wang, Changwei, Ojima, Iwao, Voleska, Iveta, Daniel, Petr, Balusikova, Kamila, Jelinek, Michael, Kovar, Jan, Rob, Lukas, Hruda, Martin, Mrhalova, Marcela, Soucek, Pavel, Vaclavikova, Radka

“…The main problem precluding successful therapy with conventional taxanes is de novo or acquired resistance to taxanes. Therefore, novel experimental taxane…”
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Association of ABC gene profiles with time to progression and resistance in ovarian cancer revealed by bioinformatics analyses by Seborova, Karolina, Vaclavikova, Radka, Soucek, Pavel, Elsnerova, Katerina, Bartakova, Alena, Cernaj, Petr, Bouda, Jiri, Rob, Lukas, Hruda, Martin, Dvorak, Pavel

“…Introduction Ovarian cancer (OC) represents a serious disease with high mortality and lack of efficient predictive and prognostic biomarkers. ATP‐binding…”
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Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model by Seborova, Karolina, Koucka, Kamila, Spalenkova, Alzbeta, Holy, Petr, Ehrlichova, Marie, Sychra, Tomas, Chen, Lei, Bendale, Hersh, Ojima, Iwao, Sandoval-Acuña, Cristian, Truksa, Jaroslav, Soucek, Pavel, Vaclavikova, Radka

“…Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug…”
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Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy by Seborova, Karolina, Hlavac, Viktor, Holy, Petr, Bjørklund, Sunniva S, Fleischer, Thomas, Rob, Lukas, Hruda, Martin, Bouda, Jiri, Mrhalova, Marcela, Allah, Mohammad Moufaq Khatar Al Obeed, Vodicka, Pavel, Fiala, Ondrej, Soucek, Pavel, Kristensen, Vessela N, Vodickova, Ludmila, Vaclavikova, Radka

“…Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced stages and frequent therapy resistance. Previous findings suggested…”
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Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma by Sychra, Tomas, Spalenkova, Alzbeta, Balatka, Stepan, Vaclavikova, Radka, Seborova, Karolina, Ehrlichova, Marie, Truksa, Jaroslav, Sandoval-Acuña, Cristian, Nemcova, Vlasta, Szabo, Arpad, Koci, Kamila, Tesarova, Tereza, Chen, Lei, Ojima, Iwao, Oliverius, Martin, Soucek, Pavel

“…Pancreatic cancer is a severe malignancy with increasing incidence and high mortality due to late diagnosis and low sensitivity to treatments. Search for the…”
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DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome by Tomasova, Kristyna, Cumova, Andrea, Seborova, Karolina, Horak, Josef, Koucka, Kamila, Vodickova, Ludmila, Vaclavikova, Radka, Vodicka, Pavel

“…There is ample evidence for the essential involvement of DNA repair and DNA damage response in the onset of solid malignancies, including ovarian cancer…”
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Non-Coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial Ovarian Cancer by Seborova, Karolina, Vaclavikova, Radka, Rob, Lukas, Soucek, Pavel, Vodicka, Pavel

“…Ovarian cancer is one of the most common causes of death among gynecological malignancies. Molecular changes occurring in the primary tumor lead to metastatic…”
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Association of lncRNA and transcriptome intersections with response to targeted therapy in metastatic renal cell carcinoma by Tesarova, Tereza, Koucka, Kamila, Vaclavikova, Radka, Seborova, Karolina, Hora, Milan, Hes, Ondrej, Pivovarcikova, Kristyna, Soucek, Pavel, Fiala, Ondrej

“…Long non-coding RNAs (lncRNAs) serve an important role in cancer progression and may be used as efficient molecular biomarkers. The present study aimed to…”
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Abstract LB096: Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma by Tomasova, Kristyna, Seborova, Karolina, Kroupa, Michal, Horak, Josef, Vodickova, Ludmila, Rob, Lukas, Hruda, Martin, Mrhalova, Marcela, Bartakova, Alena, Bouda, Jiri, Fleischer, Thomas, Kristensen, Vessela, Vodicka, Pavel, Vaclavikova, Radka

“…Abstract Impaired telomere length (TL) maintenance in ovarian tissue may play a pivotal role in epithelial ovarian carcinoma (OvC) onset. TL in either target…”
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Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma by Tomasova, Kristyna, Seborova, Karolina, Kroupa, Michal, Horak, Josef, Kavec, Miriam, Vodickova, Ludmila, Rob, Lukas, Hruda, Martin, Mrhalova, Marcela, Bartakova, Alena, Bouda, Jiri, Fleischer, Thomas, Kristensen, Vessela N., Vodicka, Pavel, Vaclavikova, Radka

“…Impaired telomere length (TL) maintenance in ovarian tissue may play a pivotal role in the onset of epithelial ovarian cancer (OvC). TL in either target or…”
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Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer by Holý, Petr, Brynychová, Veronika, Šeborová, Karolína, Haničinec, Vojtěch, Koževnikovová, Renata, Trnková, Markéta, Vrána, David, Gatěk, Jiří, Kopečková, Kateřina, Mrhalová, Marcela, Souček, Pavel

“…Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen-receptor modulators and affect cholesterol homeostasis, drug…”
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression by Holý, Petr, Hlaváč, Viktor, Šeborová, Karolína, Šůsová, Simona, Tesařová, Tereza, Rob, Lukáš, Hruda, Martin, Bouda, Jiří, Bartáková, Alena, Mrhalová, Marcela, Kopečková, Kateřina, Al Obeed Allah, Mohammad, Špaček, Jiří, Sedláková, Iva, Souček, Pavel, Václavíková, Radka

“…High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due…”
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Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Activity of Silychristin Derivatives by Viktorová, Jitka, Dobiasová, Simona, Řehořová, Kateřina, Biedermann, David, Káňová, Kristýna, Šeborová, Karolína, Václavíková, Radka, Valentová, Kateřina, Ruml, Tomáš, Křen, Vladimír, Macek, Tomáš

“…Silychristin A is the second most abundant compound of silymarin. Silymarin complex was previously described as an antioxidant with multidrug resistance…”
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ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines by Daniel, Petr, Balušíková, Kamila, Václavíková, Radka, Šeborová, Karolína, Ransdorfová, Šárka, Valeriánová, Marie, Wei, Longfei, Jelínek, Michael, Tlapáková, Tereza, Fleischer, Thomas, Kristensen, Vessela N, Souček, Pavel, Ojima, Iwao, Kovář, Jan

“…A limited number of studies are devoted to regulating expression in cancer. Hence, we aimed to unveil the regulation of expression in MCF-7 breast cancer cells…”
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IABCB1/I Amplicon Contains Cyclic AMP Response Element-Driven ITRIP6/I Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines by Daniel, Petr, Balušíková, Kamila, Václavíková, Radka, Šeborová, Karolína, Ransdorfová, Šárka, Valeriánová, Marie, Wei, Longfei, Jelínek, Michael, Tlapáková, Tereza, Fleischer, Thomas, Kristensen, Vessela N, Souček, Pavel, Ojima, Iwao, Kovář, Jan

“…A limited number of studies are devoted to regulating TRIP6 expression in cancer. Hence, we aimed to unveil the regulation of TRIP6 expression in MCF-7 breast…”
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