Search Results - "Sebolt, J S"

Development of anticancer drugs targeting the MAP kinase pathway by Sebolt-Leopold, J S

“…Since the discovery of the role of ras oncogenes in tumorigenesis, we have witnessed an explosion of research in the signal transduction area. In the quest to…”
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Novel Farnesol and Geranylgeraniol Analogues:  A Potential New Class of Anticancer Agents Directed against Protein Prenylation by Gibbs, Barbara S, Zahn, Todd J, Mu, YongQi, Sebolt-Leopold, Judith S, Gibbs, Richard A

“…Protein farnesyltransferase (FTase), the enzyme responsible for protein farnesylation, has become a key target for the rational design of cancer…”
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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo by Sebolt-Leopold, Judith S, Dudley, David T, Herrera, Roman, Becelaere, Keri Van, Wiland, Amy, Gowan, Richard C, Tecle, Haile, Barrett, Stephen D, Bridges, Alexander, Przybranowski, Sally, Leopold, W.R, Saltiel, Alan R

“…The mitogen-activated protein kinase pathway is thought to be essential in cellular growth and differentiation. Here we report the discovery of a highly potent…”
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C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice by McNamara, Dennis J, Dobrusin, Ellen, Leonard, Daniele M, Shuler, Kevon R, Kaltenbronn, James S, Quin, John, Bur, Scott, Thomas, Charles E, Doherty, Annette M, Scholten, Jeffrey D, Zimmerman, Karen K, Gibbs, Barbara S, Gowan, Richard C, Latash, Michael P, Leopold, Wilbur R, Przybranowski, Sally A, Sebolt-Leopold, Judith S

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Negative correlation of L-glutamine concentration with proliferation rate in rat hepatomas by Sebolt, J S, Weber, G

“…The concentration of L-glutamine was determined in freeze-clamped samples of normal liver of adult male fed rats (5.7-6.1 mumol/g) and in transplantable…”
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Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase by Suto, M J, Turner, W R, Arundel-Suto, C M, Werbel, L M, Sebolt-Leopold, J S

“…A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and…”
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Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma by Sebolt, J S, Aoki, T, Eble, J N, Glover, J L, Weber, G

“…The effect of the anti-tumor, anti-glutamine drug acivicin, L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, was determined on the…”
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Non-peptidic prenyltransferase inhibitors: diverse structural classes and surprising anti-cancer mechanisms by Gibbs, R A, Zahn, T J, Sebolt-Leopold, J S

“…The development of farnesyltransferase inhibitors (FTIs) has been one of the most active areas of anticancer drug development for the past ten years. This…”
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Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro by SEBOLT, J. S, SCAVONE, S. V, PINTER, C. D, HAMELEHLE, K. L, VON HOFF, D. D, JACKSON, R. C

“…A series of 2-aminoalkyl-5-nitropyrazolo[3,4,5-kl]acridines (pyrazoloacridines) was evaluated in vitro for activity against a panel of human tumor cell lines…”
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Protein prenylation: from discovery to prospects for cancer treatment by Gelb, Michael H, Scholten, Jeffrey D, Sebolt-Leopold, Judith S

“…A specific set of proteins in eukaryotic cells contain covalently attached carboxy-terminal prenyl groups (15-carbon farnesyl and 20-carbon geranylgeranyl)…”
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Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents by Sebolt-Leopold, J S, Vincent, P W, Beningo, K A, Elliott, W L, Leopold, W R, Heffner, T G, Wiley, J N, Stier, M A, Suto, M J

“…RB 6145, the ring-opened analog of RSU 1069, and PD 130908, the desoxy ring-opened analog of RSU 1069, were compared to RSU 1069 for their emetic potential in…”
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Structure−Activity Relationships of Cysteine-Lacking Pentapeptide Derivatives That Inhibit ras Farnesyltransferase by Leonard, Daniele M, Shuler, Kevon R, Poulter, Cynthia J, Eaton, Scott R, Sawyer, Tomi K, Hodges, John C, Su, Ti-Zhi, Scholten, Jeffrey D, Gowan, Richard C, Sebolt-Leopold, Judith S, Doherty, Annette M

“…Mutational activation of ras has been found in many types of human cancers, including a greater than 50% incidence in colon and about 90% in pancreatic…”
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The pyrazoloacridines: approaches to the development of a carcinoma-selective cytotoxic agent by Jackson, R C, Sebolt, J S, Shillis, J L, Leopold, W R

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Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors by Eummer, J T, Gibbs, B S, Zahn, T J, Sebolt-Leopold, J S, Gibbs, R A

“…Limonene and its metabolite perillyl alcohol are naturally-occurring isoprenoids that block the growth of cancer cells both in vitro and in vivo. This…”
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In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721) by ROBERTS, B. J, HAMELEHLE, K. L, SEBOLT, J. S, LEOPOLD, W. R

“…CI-940, PD 114,721, and PD 118,607 are structurally novel antibiotics, which were isolated from fermentation beers of a previously unknown actinomycete. They…”
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Targeting the mitogen-activated protein kinase cascade to treat cancer by Sebolt-Leopold, Judith S, Herrera, Roman

“…The RAS-mitogen activated protein kinase (MAPK) signalling pathway has long been viewed as an attractive pathway for anticancer therapies, based on its central…”
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Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor by Sebolt-Leopold, J S, Scavone, S V

“…The ability of DNA repair inhibitors to potentiate alkylating agent cytotoxicity was explored with PD 128763, a dihydroisoquinolinone known to effectively…”
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Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines by Horwitz, Jerome P, Massova, Irina, Wiese, Thomas E, Wozniak, Antoinette J, Corbett, Thomas H, Sebolt-Leopold, Judith S, Capps, David B, Leopold, Wilbur R

“…In vitro screening of a number of 2-(aminoalkyl)-5-nitropyrazolo[3,4,5- kl]acridines has previously indicated (Sebolt, J.S.; et al. Cancer Res. 1987, 47,…”
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Effects of PD 128763, a New Potent Inhibitor of Poly(ADP-Ribose) Polymerase, on X-Ray-Induced Cellular Recovery Processes in Chinese Hamster V79 Cells by Arundel-Suto, Carla M., Scavone, Sylvia V., Turner, William R., Suto, Mark J., Sebolt-Leopold, Judith S.

“…The modifying effects of PD 128763 (3,4-dihydro-5-methyl-1(2H)-isoquinolinone), a potent inhibitor of poly(adenosine-diphosphate (ADP)-ribose) polymerase, on…”
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Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer by RINEHART, John, ADJEI, Alex A, GULYAS, Stephen, MITCHELL, David Y, HERRERA, Roman, SEBOLT-LEOPOLD, Judith S, MEYER, Mark B, LORUSSO, Patricia M, WATERHOUSE, David, HECHT, J. Randolph, NATALE, Ronald B, HAMID, Oday, VARTERASIAN, Mary, ASBURY, Peggy, KALDJIAN, Eric P

“…This multicenter, open-label, phase II study was undertaken to assess the antitumor activity and safety of the oral mitogen-activated extracellular signal…”
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