Search Results - "Sebbagh, Michaël"

Rho-ROCK-Dependent Ezrin-Radixin-Moesin Phosphorylation Regulates Fas-Mediated Apoptosis in Jurkat Cells by Hebert, Marylise, Potin, Sophie, Sebbagh, Michael, Bertoglio, Jacques, Breard, Jacqueline, Hamelin, Jocelyne

“…Upon engagement by its ligand, the Fas receptor (CD95/APO-1) is oligomerized in a manner dependent on F-actin. It has been shown that ezrin, a member of the…”
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Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing by Bréard, Jacqueline, Sebbagh, Michaël, Renvoizé, Claire, Hamelin, Jocelyne, Riché, Nicole, Bertoglio, Jacques

“…Increased phosphorylation of myosin light chain (MLC) is necessary for the dynamic membrane blebbing that is observed at the onset of apoptosis. Here we…”
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The LKB1 complex-AMPK pathway: the tree that hides the forest by Sebbagh, Michaël, Olschwang, Sylviane, Santoni, Marie-Josée, Borg, Jean-Paul

“…Initially identified as the Caenorhabditis elegans PAR-4 homologue, the serine threonine kinase LKB1 is conserved throughout evolution and ubiquitously…”
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Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK by Bays, Jennifer L., Campbell, Hannah K., Heidema, Christy, Sebbagh, Michael, DeMali, Kris A.

“…Bays et al. demonstrate that application of force to E-cadherin leads to LKB1-dependent activation of AMPK and recruitment of AMPK to E-cadherin complexes to…”
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Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer by Puvirajesinghe, Tania M., Bertucci, François, Jain, Ashish, Scerbo, Pierluigi, Belotti, Edwige, Audebert, Stéphane, Sebbagh, Michael, Lopez, Marc, Brech, Andreas, Finetti, Pascal, Charafe-Jauffret, Emmanuelle, Chaffanet, Max, Castellano, Rémy, Restouin, Audrey, Marchetto, Sylvie, Collette, Yves, Gonçalvès, Anthony, Macara, Ian, Birnbaum, Daniel, Kodjabachian, Laurent, Johansen, Terje, Borg, Jean-Paul

“…The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to…”
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Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner by Sebbagh, Michael, Hamelin, Jocelyne, Bertoglio, Jacques, Solary, Eric, Bréard, Jacqueline

“…Caspase activation in target cells is a major function of granzyme B (grB) during cytotoxic lymphocyte granule-induced apoptosis. grB-mediated cell death can…”
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Regulation of LKB1/STRAD Localization and Function by E-Cadherin by Sebbagh, Michael, Santoni, Marie-Josée, Hall, Brian, Borg, Jean-Paul, Schwartz, Martin A.

“…LKB1 kinase is a tumor suppressor that is causally linked to Peutz-Jeghers syndrome [1]. In complex with the pseudokinase STRAD and the scaffolding protein…”
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The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling by Lopez Almeida, Leonor, Sebbagh, Michael, Bertucci, François, Finetti, Pascal, Wicinski, Julien, Marchetto, Sylvie, Castellano, Rémy, Josselin, Emmanuelle, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe, Borg, Jean-Paul, Santoni, Marie-Josée

“…Tumor initiation, progression, and therapeutic resistance have been proposed to originate from a subset of tumor cells, cancer stem cells (CSCs). However, the…”
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MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells by Arnaud, Camille, Sebbagh, Michaël, Nola, Sébastien, Audebert, Stéphane, Bidaut, Ghislain, Hermant, Aurélie, Gayet, Odile, Dusetti, Nelson J., Ollendorff, Vincent, Santoni, Marie-Josée, Borg, Jean-Paul, Lécine, Patrick

“…To further characterize the molecular events supporting the tumor suppressor activity of Scrib in mammals, we aim to identify new binding partners. We isolated…”
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Afadin-nectin forces its way to the front by Sebbagh, Michael, Schwartz, Martin A

“…Force transmission at cell-cell junctions critically regulates embryogenesis, tissue homeostasis, and diseases including cancer. The cadherin-catenin linkage…”
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Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1 by Sebbagh, M., Krzesinski, J.-M., Erpicum, Pauline, Rowart, Pascal, Jouret, F.

“…Background. Mesenchymal stromal cells (MSC) are fibroblast-like multipotent cells capable of tissue-repair properties. Given the essentiality of tight…”
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Insight into planar cell polarity by Sebbagh, Michael, Borg, Jean-Paul

“…Planar cell polarity or PCP refers to a uniform cellular organization within the plan, typically orthogonal to the apico-basal polarity axis. As such, PCP…”
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The zonula adherens matura redefines the apical junction of intestinal epithelia by Mangeol, Pierre, Massey-Harroche, Dominique, Sebbagh, Michael, Richard, Fabrice, Le Bivic, André, Lenne, Pierre-François

“…Cell-cell apical junctions of epithelia consist of multiprotein complexes that organize as belts regulating cell-cell adhesion, permeability, and mechanical…”
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The Human PDZome: A Gateway to PSD95-Disc Large-Zonula Occludens (PDZ)-mediated Functions by Belotti, Edwige, Polanowska, Jolanta, Daulat, Avais M., Audebert, Stéphane, Thomé, Virginie, Lissitzky, Jean-Claude, Lembo, Frédérique, Blibek, Karim, Omi, Shizue, Lenfant, Nicolas, Gangar, Akanksha, Montcouquiol, Mireille, Santoni, Marie-Josée, Sebbagh, Michael, Aurrand-Lions, Michel, Angers, Stéphane, Kodjabachian, Laurent, Reboul, Jérome, Borg, Jean-Paul

“…Protein–protein interactions organize the localization, clustering, signal transduction, and degradation of cellular proteins and are therefore implicated in…”
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The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome by Prebet, Thomas, Lhoumeau, Anne-Catherine, Arnoulet, Christine, Aulas, Anaïs, Marchetto, Sylvie, Audebert, Stéphane, Puppo, Francesca, Chabannon, Christian, Sainty, Danielle, Santoni, Marie-Josée, Sebbagh, Michael, Summerour, Virginia, Huon, Yannick, Shin, Won-Sik, Lee, Seung-Taek, Esterni, Benjamin, Vey, Norbert, Borg, Jean-Paul

“…The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway. It plays a major role during…”
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Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling by Puppo, Francesca, Thomé, Virginie, Lhoumeau, Anne-Catherine, Cibois, Marie, Gangar, Akanksha, Lembo, Frédérique, Belotti, Edwige, Marchetto, Sylvie, Lécine, Patrick, Prébet, Thomas, Sebbagh, Michael, Shin, Won-Sik, Lee, Seung-Taek, Kodjabachian, Laurent, Borg, Jean-Paul

“…The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog…”
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Scrib regulates PAK activity during the cell migration process by Nola, Sébastien, Sebbagh, Michael, Marchetto, Sylvie, Osmani, Naël, Nourry, Claire, Audebert, Stéphane, Navarro, Christel, Rachel, Rivka, Montcouquiol, Mireille, Sans, Nathalie, Etienne-Manneville, Sandrine, Borg, Jean-Paul, Santoni, Marie-Josée

“…Genetic studies have highlighted the key role of Scrib in the development of Metazoans. Deficiency in Scrib impairs many aspects of cell polarity and cell…”
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Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer by Puvirajesinghe, Tania M, Bertucci, François, Jain, Ashish, Scerbo, Pierluigi, Belotti, Edwige, Audebert, Stéphane, Sebbagh, Michael, Lopez, Marc, Brech, Andreas, Finetti, Pascal, Charafe-Jauffret, Emmanuelle, Chaffanet, Max, Castellano, Rémy, Restouin, Audrey, Marchetto, Sylvie, Collette, Yves, Gonçalvès, Anthony, Macara, Ian, Birnbaum, Daniel, Kodjabachian, Laurent, Johansen, Terje, Borg, Jean-Paul

“…The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to…”
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The LKB1 complex-AMPK pathway: the tree that hides the forest: The LKB1 complex-AMPK pathway by Sebbagh, Michael, Olschwang, Sylviane, Santoni, Marie-Josée, Borg, Jean-Paul

“…Initially identified as the Caenorhabditis elegans PAR-4 homologue, the serine threonine kinase LKB1 is conserved throughout evolution and ubiquitously…”
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The Cell Polarity PTK7 Receptor Is Expressed in Myeloid Cells and Acts as a Modulator of the Chemotherapeutic Response in AML Patients by Prebet, Thomas, Lhoumeau, Anne Catherine, Arnoulet, Christine, Aulas, Anais, Marchetto, Sylvie, Sebbagh, Michael, Esterni, Benjamin, Vey, Norbert, Borg, Jean Paul

“…Abstract 1571 Poster Board I-596 The pseudo tyrosine kinase receptor 7 (PTK7) is an orphean tyrosine kinase receptor assigned to the planar cell polarity…”
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