Search Results - "Sebayang, Boni F"
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The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes
Published in PLoS biology (12-03-2018)“…Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in…”
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Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1
Published in Infection and immunity (17-02-2022)“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a diverse family of multidomain proteins expressed on the surface of malaria-infected…”
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Australian mosquito assemblages vary between ground and sub-canopy habitats
Published in Parasites & vectors (07-10-2021)“…The surveillance and control of mosquito-borne diseases is dependent upon understanding the bionomics and distribution of the vectors. Most studies of mosquito…”
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Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia
Published in International journal for parasitology -- drugs and drug resistance (01-12-2021)“…Drug resistant Plasmodium parasites are a major threat to malaria control and elimination. After reports of high levels of multidrug resistant P. falciparum…”
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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
Published in Nature communications (25-11-2014)“…The quest for new antimalarial drugs, especially those with novel modes of action, is essential in the face of emerging drug-resistant parasites. Here we…”
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Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax
Published in Antimicrobial agents and chemotherapy (01-10-2015)“…The 4-aminoquinoline naphthoquine (NQ) and the thiazine dye methylene blue (MB) have potent in vitro efficacies against Plasmodium falciparum, but…”
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Contrasting ex vivo efficacies of "reversed chloroquine" compounds in chloroquine-resistant Plasmodium falciparum and P. vivax isolates
Published in Antimicrobial agents and chemotherapy (01-09-2015)“…Chloroquine (CQ) has been the mainstay of malaria treatment for more than 60 years. However, the emergence and spread of CQ resistance now restrict its use to…”
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Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry
Published in Malaria journal (24-10-2015)“…The emergence and spread of multidrug-resistant Plasmodium falciparum and Plasmodium vivax highlights the need for objective measures of ex vivo drug…”
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Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
Published in Malaria journal (05-05-2016)“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in…”
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Quinolone-3-diarylethers: a new class of antimalarial drug
Published in Science translational medicine (20-03-2013)“…The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention,…”
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