Search Results - "Sebastián, Alvaro"

amplisas: a web server for multilocus genotyping using next‐generation amplicon sequencing data by Sebastian, Alvaro, Herdegen, Magdalena, Migalska, Magdalena, Radwan, Jacek

“…Next‐generation sequencing (NGS) technologies are revolutionizing the fields of biology and medicine as powerful tools for amplicon sequencing (AS). Using…”
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Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants by Sanchis, Ivan, Spinelli, Roque, Aschemacher, Nicolas, Siano, Alvaro Sebastían

“…The use of acetylcholinesterase (AChE) inhibitors, antioxidants or multitarget compounds are among the main strategies against Alzheimer’s disease (AD)…”
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Profiling of the TCRβ repertoire in non-model species using high-throughput sequencing by Migalska, Magdalena, Sebastian, Alvaro, Radwan, Jacek

“…In recent years, immune repertoire profiling with high-throughput sequencing (HTS) has advanced our understanding of adaptive immunity. However, fast progress…”
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N-terminome analysis of the human mitochondrial proteome by Vaca Jacome, Alvaro Sebastian, Rabilloud, Thierry, Schaeffer-Reiss, Christine, Rompais, Magali, Ayoub, Daniel, Lane, Lydie, Bairoch, Amos, Van Dorsselaer, Alain, Carapito, Christine

“…The high throughput characterization of protein N‐termini is becoming an emerging challenge in the proteomics and proteogenomics fields. The present study…”
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Avant-garde: an automated data-driven DIA data curation tool by Vaca Jacome, Alvaro Sebastian, Peckner, Ryan, Shulman, Nicholas, Krug, Karsten, DeRuff, Katherine C., Officer, Adam, Christianson, Karen E., MacLean, Brendan, MacCoss, Michael J., Carr, Steven A., Jaffe, Jacob D.

“…Several challenges remain in data-independent acquisition (DIA) data analysis, such as to confidently identify peptides, define integration boundaries, remove…”
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Testing genotyping strategies for ultra‐deep sequencing of a co‐amplifying gene family: MHC class I in a passerine bird by Biedrzycka, Aleksandra, Sebastian, Alvaro, Migalska, Magdalena, Westerdahl, Helena, Radwan, Jacek

“…Characterization of highly duplicated genes, such as genes of the major histocompatibility complex (MHC), where multiple loci often co‐amplify, has until…”
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Analysis of the DNA-Binding Activities of the Arabidopsis R2R3-MYB Transcription Factor Family by One-Hybrid Experiments in Yeast by Kelemen, Zsolt, Sebastian, Alvaro, Xu, Wenjia, Grain, Damaris, Salsac, Fabien, Avon, Alexandra, Berger, Nathalie, Tran, Joseph, Dubreucq, Bertrand, Lurin, Claire, Lepiniec, Loïc, Contreras-Moreira, Bruno, Dubos, Christian

“…The control of growth and development of all living organisms is a complex and dynamic process that requires the harmonious expression of numerous genes. Gene…”
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Natural multi-target modulators of pathological pathways in Alzheimer's disease isolated from the Rhinella arenarum skin by Spinelli, Roque, Rietmann, Álvaro, Sanchis, Ivan, Siano, Álvaro Sebastián

“…The skin of anuran amphibians is a rich source of compounds with great medicinal potential. Alzheimer's disease (AD) is a complex disease associated with…”
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The Neurotoxic Role of Extracellular Tau Protein by Sebastián-Serrano, Álvaro, de Diego-García, Laura, Díaz-Hernández, Miguel

“…Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer's disease (AD) being the most…”
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FootprintDB: Analysis of Plant Cis-Regulatory Elements, Transcription Factors, and Binding Interfaces by Contreras-Moreira, Bruno, Sebastian, Alvaro

“…FootprintDB is a database and search engine that compiles regulatory sequences from open access libraries of curated DNA cis-elements and motifs, and their…”
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Extreme MHC class I diversity in the sedge warbler (Acrocephalus schoenobaenus); selection patterns and allelic divergence suggest that different genes have different functions by Biedrzycka, Aleksandra, O'Connor, Emily, Sebastian, Alvaro, Migalska, Magdalena, Radwan, Jacek, Zając, Tadeusz, Bielański, Wojciech, Solarz, Wojciech, Ćmiel, Adam, Westerdahl, Helena

“…Recent work suggests that gene duplications may play an important role in the evolution of immunity genes. Passerine birds, and in particular Sylvioidea…”
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Blood parasites shape extreme major histocompatibility complex diversity in a migratory passerine by Biedrzycka, Aleksandra, Bielański, Wojciech, Ćmiel, Adam, Solarz, Wojciech, Zając, Tadeusz, Migalska, Magdalena, Sebastian, Alvaro, Westerdahl, Helena, Radwan, Jacek

“…Pathogens are one of the main forces driving the evolution and maintenance of the highly polymorphic genes of the vertebrate major histocompatibility complex…”
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Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics by Peckner, Ryan, Myers, Samuel A, Jacome, Alvaro Sebastian Vaca, Egertson, Jarrett D, Abelin, Jennifer G, MacCoss, Michael J, Carr, Steven A, Jaffe, Jacob D

“…Data-independent-acquisition-based mass spectrometry enables highly reproducible proteome analysis, but results interpretation is challenging owing to the…”
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P2X7 receptor inhibition ameliorates ubiquitin-proteasome system dysfunction associated with Alzheimer's disease by Bianchi, Carolina, Alvarez-Castelao, Beatriz, Sebastián-Serrano, Álvaro, Di Lauro, Caterina, Soria-Tobar, Lucia, Nicke, Annette, Engel, Tobias, Díaz-Hernández, Miguel

“…Over recent years, increasing evidence suggests a causal relationship between neurofibrillary tangles (NFTs) formation, the main histopathological hallmark of…”
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Amphibian skin extracts as source of bioactive multi-target agents against different pathways of Alzheimer's disease by Spinelli, Roque, Aimaretti, Florencia María, López, Javier Alejandro, Siano, Alvaro Sebastián

“…Natural products represent a rich source of bioactive compounds that have been historically used to obtain substances with great medicinal potential. The skin…”
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Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex by Cubelos, Beatriz, Sebastián-Serrano, Alvaro, Beccari, Leonardo, Calcagnotto, Maria Elisa, Cisneros, Elsa, Kim, Seonhee, Dopazo, Ana, Alvarez-Dolado, Manuel, Redondo, Juan Miguel, Bovolenta, Paola, Walsh, Christopher A., Nieto, Marta

“…Dendrite branching and spine formation determines the function of morphologically distinct and specialized neuronal subclasses. However, little is known about…”
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Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality by Martínez-Frailes, Carlos, Di Lauro, Caterina, Bianchi, Carolina, de Diego-García, Laura, Sebastián-Serrano, Álvaro, Boscá, Lisardo, Díaz-Hernández, Miguel

“…Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles,…”
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The Role of P2X7 Receptor in Alzheimer’s Disease by Francistiová, Linda, Bianchi, Carolina, Di Lauro, Caterina, Sebastián-Serrano, Álvaro, de Diego-García, Laura, Kobolák, Julianna, Dinnyés, András, Díaz-Hernández, Miguel

“…Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease characterized by a progressive cognitive decline associated with global brain damage…”
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Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1 by Pose-Utrilla, Julia, García-Guerra, Lucía, Del Puerto, Ana, Martín, Abraham, Jurado-Arjona, Jerónimo, De León-Reyes, Noelia S., Gamir-Morralla, Andrea, Sebastián-Serrano, Álvaro, García-Gallo, Mónica, Kremer, Leonor, Fielitz, Jens, Ireson, Christofer, Pérez-Álvarez, Mª José, Ferrer, Isidro, Hernández, Félix, Ávila, Jesús, Lasa, Marina, Campanero, Miguel R., Iglesias, Teresa

“…Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress…”
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TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy by Sebastián-Serrano, Álvaro, Merchán-Rubira, Jesús, Di Lauro, Caterina, Bianchi, Carolina, Soria-Tobar, Lucía, Narisawa, Sonoko, Millán, José L., Ávila, Jesús, Hernández, Félix, Díaz-Hernández, Miguel

“…Tauopathies are a family of neurodegenerative diseases characterized by the presence of abnormally hyperphosphorylated Tau protein. Several studies have…”
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