Search Results - "Sebald, Walter"

The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin by Khattab, Hany Mohamed, Kubota, Satoshi, Takigawa, Masaharu, Kuboki, Takuo, Sebald, Walter

“…The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the…”
Get full text

N-terminal specificity of PEGylation of human bone morphogenetic protein-2 at acidic pH by Hu, Junli, Sebald, Walter

“…Site-specific PEGylation offers the possibility to modify a therapeutic protein without interfering with its biological activity. Previously, a preferential…”
Get full text

Receptor oligomerization and beyond: a case study in bone morphogenetic proteins by Heinecke, Kai, Seher, Axel, Schmitz, Werner, Mueller, Thomas D, Sebald, Walter, Nickel, Joachim

“…Transforming growth factor (TGF)beta superfamily members transduce signals by oligomerizing two classes of serine/threonine kinase receptors, termed type I and…”
Get full text

GDF-5 can act as a context-dependent BMP-2 antagonist by Klammert, Uwe, Mueller, Thomas D, Hellmann, Tina V, Wuerzler, Kristian K, Kotzsch, Alexander, Schliermann, Anna, Schmitz, Werner, Kuebler, Alexander C, Sebald, Walter, Nickel, Joachim

“…Bone morphogenetic protein (BMP)-2 and growth and differentiation factor (GDF)-5 are two related transforming growth factor (TGF)-β family members with…”
Get full text

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity by Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Sebald, Walter, Müller, Thomas D

“…Dysregulation of growth and differentiation factor 5 (GDF‐5) signalling, a member of the TGF‐β superfamily, is strongly linked to skeletal malformation…”
Get full text

The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways by Nohe, Anja, Hassel, Sylke, Ehrlich, Marcelo, Neubauer, Florian, Sebald, Walter, Henis, Yoav I, Knaus, Petra

“…Bone morphogenetic proteins (BMPs) are multifunctional proteins regulating cell growth, differentiation, and apoptosis. BMP-2 signals via two types of…”
Get full text

Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing by Yano, Koichi, Hoshino, Masatoshi, Ohta, Yoichi, Manaka, Tomoya, Naka, Yoshifumi, Imai, Yuuki, Sebald, Walter, Takaoka, Kunio

“…One problem associated with clinical application of CHO-derived recombinant human bone morphogenetic protein (C-BMP-2) is its high cost due to the need for use…”
Get full text

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding by Zhang, Jin-li, Qiu, Li-yan, Kotzsch, Alexander, Weidauer, Stella, Patterson, Lucy, Hammerschmidt, Matthias, Sebald, Walter, Mueller, Thomas D.

“…Crossveinless 2 (CV-2) is an extracellular BMP modulator protein belonging to the Chordin family. During development it is expressed at sites of high BMP…”
Get full text

Utilizing BMP-2 muteins for treatment of multiple myeloma by Seher, Axel, Lagler, Charlotte, Stühmer, Thorsten, Müller-Richter, Urs Dietmar Achim, Kübler, Alexander Christian, Sebald, Walter, Müller, Thomas Dieter, Nickel, Joachim

“…Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients…”
Get full text

von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms by Zhang, Jin-Li, Huang, Yi, Qiu, Li-Yan, Nickel, Joachim, Sebald, Walter

“…Bone morphogenetic protein (BMP) function is regulated in the extracellular space by many modulator proteins, including those containing a von Willebrand…”
Get full text

Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand by Saremba, Stefan, Nickel, Joachim, Seher, Axel, Kotzsch, Alexander, Sebald, Walter, Mueller, Thomas D

“…Bone morphogenetic proteins (BMPs), together with transforming growth factor (TGF)-β and activins/inhibins, constitute the TGF-β superfamily of ligands. This…”
Get full text

Crystal structure of the BMP-2-BRIA ectodomain complex by Dreyer, Matthias K, Kirsch, Thomas, Sebald, Walter

“…Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-β (TGF-β) superfamily of multifunctional cytokines. BMP-2 can induce ectopic…”
Get full text

The BMP2 antagonist inhibitor L51P enhances the osteogenic potential of BMP2 by simultaneous and delayed synergism by Khattab, Hany Mohamed, Ono, Mitsuaki, Sonoyama, Wataru, Oida, Yasutaka, Shinkawa, Shigehiko, Yoshioka, Yuya, Maekawa, Kenji, Tabata, Yasuhiko, Sugama, Kazushige, Sebald, Walter, Kuboki, Takuo

“…Abstract Bone morphogenetic protein 2 (BMP2) is a potent osteoinductive cytokine that plays crucial roles in bone repair. However, large amounts of BMP2 are…”
Get full text

Molecular recognition of BMP-2 and BMP receptor IA by Mueller, Thomas D, Keller, Sascha, Nickel, Joachim, Zhang, Jin-Li, Sebald, Walter

“…Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta superfamily regulate the development, maintenance and regeneration of tissues and…”
Get full text

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation by Rentzsch, Fabian, Zhang, Jinli, Kramer, Carina, Sebald, Walter, Hammerschmidt, Matthias

“…Signaling by bone morphogenetic proteins (Bmps) plays a pivotal role in developmental and pathological processes, and is regulated by a complex interplay with…”
Get full text

Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN by Seemann, Petra, Brehm, Anja, König, Jana, Reissner, Carsten, Stricker, Sigmar, Kuss, Pia, Haupt, Julia, Renninger, Stephanie, Nickel, Joachim, Sebald, Walter, Groppe, Jay C, Plöger, Frank, Pohl, Jens, Schmidt-von Kegler, Mareen, Walther, Maria, Gassner, Ingmar, Rusu, Cristina, Janecke, Andreas R, Dathe, Katarina, Mundlos, Stefan

“…Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface…”
Get full text

In vitro osteogenic response of rat bone marrow cells to bFGF and BMP-2 treatments by Varkey, Mathew, Kucharski, Cezary, Haque, Takrima, Sebald, Walter, Uludağ, Hasan

“…Basic fibroblast growth factor (bFGF) and bone morphogenetic protein-2 (BMP-2) are actively pursued for stimulation of bone formation. To assess their promise…”
Get more information

Structure Analysis of Bone Morphogenetic Protein-2 Type I Receptor Complexes Reveals a Mechanism of Receptor Inactivation in Juvenile Polyposis Syndrome by Kotzsch, Alexander, Nickel, Joachim, Seher, Axel, Heinecke, Kai, van Geersdaele, Laura, Herrmann, Thomas, Sebald, Walter, Mueller, Thomas D.

“…Bone morphogenetic proteins regulate many developmental processes during embryogenesis as well as tissue homeostasis in the adult. Signaling of bone…”
Get full text

Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids by Börner, Christine, Höllt, Volker, Sebald, Walter, Kraus, Jürgen

“…Effects of cannabinoids (CBs) are mediated by two types of receptors, CB1 and CB2. In this report, we investigated whether CBs regulate gene expression of…”
Get full text

Structure, binding, and antagonists in the IL-4/IL-13 receptor system by Mueller, Thomas D, Zhang, Jin-Li, Sebald, Walter, Duschl, Albert

“…Interleukin-4 (IL-4) and IL-13 are the only cytokines known to bind to the receptor chain IL-4Rα. Receptor sharing by these two cytokines is the molecular…”
Get full text