Search Results - "Sebak, Aya"

Phytochemical-derived tumor-associated macrophage remodeling strategy using Phoenix dactylifera L. boosted photodynamic therapy in melanoma via H19/iNOS/PD-L1 axis by Soliman, Aya H., Youness, Rana A., Sebak, Aya A., Handoussa, Heba

“…•Tumor-associated macrophages (TAMs) limit PDT efficacy in melanoma.•Phoenix dactylifera L. (Sukkari date fraction) promoted the repolarization of TAMs from…”
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Multitarget, multiagent PLGA nanoparticles for simultaneous tumor eradication and TME remodeling in a melanoma mouse model by Ramzy, Asmaa, Soliman, Aya H., Hassanein, Sally I., Sebak, Aya A.

“…Despite the fact that chemoimmunotherapy has emerged as a key component in the era of cancer immunotherapy, it is challenged by the complex tumor…”
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A Naturally Derived Carrier for Photodynamic Treatment of Squamous Cell Carcinoma: In Vitro and In Vivo Models by Nasr, Soad, Rady, Mai, Sebak, Aya, Gomaa, Iman, Fayad, Walid, El Gaafary, Menna, Abdel-Kader, Mahmoud, Syrovets, Tatiana, Simmet, Thomas

“…Photodynamic therapy (PDT) is a non-invasive treatment strategy that includes the combination of three components—a photosensitizer, a light source, and tissue…”
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Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting - Part I: In vitro Release and Intracellular Uptake Perspective by Sebak, Aya Ahmed, Gomaa, Iman Emam Omar, ElMeshad, Aliaa Nabil, Farag, Mahmoud Hussien, Breitinger, Ulrike, Breitinger, Hans-Georg, AbdelKader, Mahmoud Hashem

“…Protein corona (PC) deposition on nanoparticles (NPs) in biological systems contributes to a great extent to NPs' fates; their targeting potential, the…”
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Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting - Part II: In vitro and in vivo Kinetics Study by Sebak, Aya Ahmed, Gomaa, Iman Emam Omar, ElMeshad, Aliaa Nabil, Farag, Mahmoud Hussien, Breitinger, Ulrike, Breitinger, Hans-Georg, AbdelKader, Mahmoud Hashem

“…Nanoparticles (NPs), upon introduction to the biological systems, become wrapped by serum and cellular proteins constituting the protein corona (PC). This PC…”
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Drugless nanoparticles tune-up an array of intertwined pathways contributing to immune checkpoint signaling and metabolic reprogramming in triple-negative breast cancer by Ramzy, Asmaa, ElSafy, Sara, Elshoky, Hisham A, Soliman, Aya, Youness, Rana, Mansour, Samar, Sebak, Aya

“…Metabolic reprogramming 'Warburg effect' and immune checkpoint signaling are immunosuppressive hallmarks of triple-negative breast cancer (TNBC) contributing…”
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Liposomal delivery of ferrous chlorophyllin: A novel third generation photosensitizer for in vitro PDT of melanoma by Gomaa, Iman, Sebak, Aya, Afifi, Nagia, Abdel-Kader, Mahmoud

“…Graphical abstract…”
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Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma by Ezzeldeen, Yasmeen, Swidan, Shady, ElMeshad, Aliaa, Sebak, Aya

“…Honokiol (HK) is a natural bioactive compound with proven antineoplastic properties against melanoma. However, it shows very low bioavailability when…”
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Targeted photodynamic-induced singlet oxygen production by peptide-conjugated biodegradable nanoparticles for treatment of skin melanoma by Sebak, Aya Ahmed, Gomaa, Iman Emam Omar, ElMeshad, Aliaa Nabil, AbdelKader, Mahmoud Hashem

“…Targeted photodynamic-induced singlet oxygen production by peptide-conjugated biodegradable nanoparticles for treatment of skin melanoma. [Display omitted]…”
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The other side to the use of active targeting ligands; the case of folic acid in the targeting of breast cancer by Helmy, Lama A., Abdel-Halim, Mohammed, Hassan, Raghda, Sebak, Aya, Farghali, Haithem A.M., Mansour, Samar, Tammam, Salma N.

“…Due to its overexpression in cancer cells, the folate receptor (FR) is heavily exploited in the active targeting of nanoparticles (NPs). Its ligand, folic acid…”
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Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting--Part II: In vitro and in vivo Kinetics Study by Sebak, Aya Ahmed, Gomaa, Iman Emam Omar, ElMeshad, Aliaa Nabil, Farag, Mahmoud Hussien, Breitinger, Ulrike, Breitinger, Hans-Georg, Hashem, Mahmoud, AbdelKader

“…Introduction: Nanoparticles (NPs), upon introduction to the biological systems, become wrapped by serum and cellular proteins constituting the protein corona…”
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Nano‐Mediated PDT as a Multifunctional Immunomodulatory Agent in the Intricate Milieu of Melanoma by Sebak, Aya A., Abdel‐Halim, Mohammad, Abdelrahman, Mostafa, Mohamed, Gehad, El‐Tayeb, Tarek, Gomaa, Iman

“…Abstract The complexity of the tumor microenvironment (TME) and nutrient competition represent the main causes of therapy resistance in cancers, including…”
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