Search Results - "Sebag, C"

Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome by Sebag, Sara C, Bastarache, Julie A, Ware, Lorraine B

“…Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are characterized by excessive intraalveolar fibrin deposition, driven, at least in part…”
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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue by Sebag, Sara C., Zhang, Zeyuan, Qian, Qingwen, Li, Mark, Zhu, Zhiyong, Harata, Mikako, Li, Wenxian, Zingman, Leonid V., Liu, Limin, Lira, Vitor A., Potthoff, Matthew J., Bartelt, Alexander, Yang, Ling

“…Brown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status, but the underlying molecular mechanisms are incompletely…”
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A medium chain fatty acid, 6-hydroxyhexanoic acid (6-HHA), protects against obesity and insulin resistance by Sebag, Sara C., Hao, Meihua, Qian, Qingwen, Upara, Chawin, Ding, Qiong, Zhu, Min, Banas, Jeffrey A., Cao, Huojun, Hong, Liu, Yang, Ling

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Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress by Bastarache, Julie A, Sebag, Sara C, Clune, Jennifer K, Grove, Brandon S, Lawson, William E, Janz, David R, Roberts, 2nd, L Jackson, Dworski, Ryszard, Mackman, Nigel, Ware, Lorraine B

“…Systemic blockade of tissue factor (TF) attenuates acute lung injury (ALI) in animal models of sepsis but the effects of global TF deficiency are unknown. We…”
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Lysosomal physiology and pancreatic lysosomal stress in diabetes mellitus by Hao, Meihua, Sebag, Sara C, Qian, Qingwen, Yang, Ling

“…Endocrine and exocrine functions of the pancreas control nutritional absorption, utilisation and systemic metabolic homeostasis. Under basal conditions, the…”
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The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB by Zhang, Zeyuan, Qian, Qingwen, Li, Mark, Shao, Fan, Ding, Wen-Xing, Lira, Vitor A., Chen, Sophia X., Sebag, Sara C., Hotamisligil, Gökhan S., Cao, Huojun, Yang, Ling

“…Defective macroautophagy/autophagy and a failure to initiate the adaptive unfolded protein response (UPR) in response to the endoplasmic reticulum (ER) stress…”
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Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development by Nixon, Benjamin R, Williams, Alexandra F, Glennon, Michael S, de Feria, Alejandro E, Sebag, Sara C, Baldwin, H Scott, Becker, Jason R

“…It remains unclear how perturbations in cardiomyocyte sarcomere function alter postnatal heart development. We utilized murine models that allowed manipulation…”
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Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation by Roy, Stephen J, Koval, Olha M, Sebag, Sara C, Ait-Aissa, Karima, Allen, Bryan G, Spitz, Douglas R, Grumbach, Isabella M

“…Damage to the microvascular endothelium is an important part of normal tissue injury after radiation exposure and driven by the production of pro-oxidants. The…”
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Retraction notice to Corrigendum to “Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation” [Free Radical Biol. Med. 146, January (2020) 287–298] by Roy, Stephen J., Koval, Olha M., Sebag, Sara C., Ait-Aissa, Karima, Allen, Bryan G., Spitz, Douglas R., Grumbach, Isabella M.

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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Retraction notice to “Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation” [Free Radic. Biol. Med. 146C (2020) 287–298] by Roy, Stephen J., Koval, Olha M., Sebag, Sara C., Ait-Aissa, Karima, Allen, Bryan G., Spitz, Douglas R., Grumbach, Isabella M.

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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Corrigendum to “Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function” [362/2 (2018) 400–411] by Sebag, Sara C., Koval, Olha M., Paschke, John D., Winters, Christopher J., Comellas, Alejandro P., Grumbach, Isabella M.

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Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function by Sebag, Sara C., Koval, Olha M., Paschke, John D., Winters, Christopher J., Comellas, Alejandro P., Grumbach, Isabella M.

“…Mitochondria are increasingly recognized as key mediators of acute cellular stress responses in asthma. However, the distinct roles of regulators of…”
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Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma by Morris, Angie S, Sebag, Sara C, Paschke, John D, Wongrakpanich, Amaraporn, Ebeid, Kareem, Anderson, Mark E, Grumbach, Isabella M, Salem, Aliasger K

“…Asthma is a common lung disease affecting over 300 million people worldwide and is associated with increased reactive oxygen species, eosinophilic airway…”
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Nuclear localized Raf1 isoform alters DNA‐dependent protein kinase activity and the DNA damage response by Nixon, Benjamin R., Sebag, Sara C., Glennon, Michael S., Hall, Eric J., Kounlavong, Emily S., Freeman, Michael L., Becker, Jason R.

“…ABSTRACT Raf1/c‐Raf is a well‐characterized serine/threonine–protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have…”
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Mechanical Stretch Inhibits Lipopolysaccharide-induced Keratinocyte-derived Chemokine and Tissue Factor Expression While Increasing Procoagulant Activity in Murine Lung Epithelial Cells by Sebag, Sara C., Bastarache, Julie A., Ware, Lorraine B.

“…Previous studies have shown that the innate immune stimulant LPS augments mechanical ventilation-induced pulmonary coagulation and inflammation. Whether these…”
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CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis by Winters, Christopher J, Koval, Olha, Murthy, Shubha, Allamargot, Chantal, Sebag, Sara C, Paschke, John D, Jaffer, Omar A, Carter, A Brent, Grumbach, Isabella M

“…The calcium and calmodulin-dependent kinase II (CaMKII) translates increases in intracellular Ca(2+) into downstream signaling events. Its function in…”
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Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma by Sebag, Sara C, Koval, Olha M, Paschke, John D, Winters, Christopher J, Jaffer, Omar A, Dworski, Ryszard, Sutterwala, Fayyaz S, Anderson, Mark E, Grumbach, Isabella M

“…Excessive ROS promote allergic asthma, a condition characterized by airway inflammation, eosinophilic inflammation, and increased airway hyperreactivity (AHR)…”
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Interferon-γ and tumor necrosis factor-α act synergistically to up-regulate tissue factor in alveolar epithelial cells by Bastarache, Julie A., Sebag, Sara C., Grove, Brandon S., Ware, Lorraine B.

“…ABSTRACT Fibrin deposition mediated through activation of tissue factor (TF) in the airspace is central to the pathogenesis of acute lung injury. Defining the…”
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P417Reliability and reproducibility of surface and intracardiac electrocardiograms in patients with syncope by Lallemand, P, Younsi, S, Coquard, C, Dinanian, S, Sebag, C, Extramiana, F, Gandjbakhch, E, Lellouche, N, Marijon, E, Algalarrondo, V

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Complete atrioventricular block following mediastinal irradiation: a report of six cases by Slama, M S, Le Guludec, D, Sebag, C, Leenhardt, A R, Davy, J M, Pellerin, D E, Drieu, L H, Victor, J, Brechenmacher, C, Motté, G

“…Complete atrioventricular block (AVB) following radiotherapy has been reported rarely, usually after high dose mediastinal irradiation for Hodgkin's disease or…”
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