Search Results - "Seay, U"
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NPY/Y1 receptor‐mediated vasoconstrictory and proliferative effects in pulmonary hypertension
Published in British journal of pharmacology (01-08-2014)“…Background and Purpose Pulmonary arteries (PAs) are innervated, but little is known about the role of neuronal axis in pulmonary hypertension (PH). Here, we…”
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NPY / Y 1 receptor‐mediated vasoconstrictory and proliferative effects in pulmonary hypertension
Published in British journal of pharmacology (01-08-2014)“…Background and Purpose Pulmonary arteries ( PA s) are innervated, but little is known about the role of neuronal axis in pulmonary hypertension ( PH ). Here,…”
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Information on new drugs at market entry: retrospective analysis of health technology assessment reports versus regulatory reports, journal publications, and registry reports
Published in BMJ (Online) (26-02-2015)“…Background When a new drug becomes available, patients and doctors require information on its benefits and harms. In 2011, Germany introduced the early benefit…”
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Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent
Published in The Journal of pharmacology and experimental therapeutics (01-12-2005)“…Vascular smooth muscle cells (VSMCs) constitute the major cellular component of the vessel tunica media. VSMC proliferation is a key feature in developing…”
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Caveolin-1 Facilitates Mechanosensitive Protein Kinase B (Akt) Signaling In Vitro and In Vivo
Published in Circulation research (01-04-2005)“…Mechanotransduction represents an integral part of vascular homeostasis and contributes to vascular lesion formation. Previously, we demonstrated a…”
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Hypoxia‐driven proliferation of human pulmonary artery fibroblasts: cross‐talk between HIF‐1α and an autocrine angiotensin system
Published in The FASEB journal (01-05-2005)“…ABSTRACT Pulmonary artery adventitial fibroblasts (FBPA) may play a central role in lung vascular remodeling under conditions of hypoxia and inflammation, the…”
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Unmodified phosphodiester antisense oligodeoxynucleotides to the BCR-ABL junction do not suppress Philadelphia-positive clonogenic cells
Published in Acta haematologica (01-01-1994)“…The BCR-ABL fusion gene is directly involved in the pathogenesis of chronic myeloid leukemia (CML). Specific inhibition of the BCR-ABL gene expression with…”
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Cell Cycle Protein Expression in Vascular Smooth Muscle Cells In Vitro and In Vivo Is Regulated Through Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin
Published in Arteriosclerosis, thrombosis, and vascular biology (01-07-2001)“…Cell cycle progression represents a key event in vascular proliferative diseases, one that depends on an increased rate of protein synthesis. An increase in…”
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Calpain counteracts mechanosensitive apoptosis of vascular smooth muscle cells in vitro and in vivo
Published in The FASEB journal (01-02-2008)“…Mechanical forces contribute to vascular remodeling processes. Elevated mechanical stress causes apoptosis of vascular smooth muscle cells (VSMCs) within the…”
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Mechanosensitive p27Kip1 regulation and cell cycle entry in vascular smooth muscle cells
Published in Circulation (New York, N.Y.) (05-08-2003)“…Cyclic stretch plays an important role in the homeostasis of vessel structure. Increased forces might, however, contribute to remodeling processes, resulting…”
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Protective effect of 3-deazaadenosine in a rat model of lipopolysaccharide-induced myocardial dysfunction
Published in Shock (Augusta, Ga.) (01-03-2003)“…Severe sepsis is accompanied by a profound depression of myocardial contractility. Leukocyte adhesion with subsequent local excess nitric oxide and reactive…”
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Expression of the nerve growth factor receptor c-TRK in human myeloid leukaemia cells
Published in British journal of haematology (01-10-1996)“…Nerve growth factor (NGF) is of major importance for the survival, development and maintenance of peripheral sympathetic and central neuronal tissue. Most of…”
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