Search Results - "Seavers, Lisa C. A."

Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design by Wyatt, Paul G, Woodhead, Andrew J, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Davis, Deborah J, Devine, Lindsay A, Early, Theresa R, Feltell, Ruth E, Lewis, E. Jonathan, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A, Smith, Donna-Michelle, Squires, Matt S, Trewartha, Gary, Walker, Margaret T, Woolford, Alison J.-A

“…The application of fragment-based screening techniques to cyclin dependent kinase 2 (CDK2) identified multiple (>30) efficient, synthetically tractable small…”
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Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors by Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W, Seavers, Lisa C. A, van Montfort, Rob L. M

“…The screening of fragments is an alternative approach to high-throughput screening for the identification of leads for therapeutic targets. Fragment hits have…”
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Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B by Collins, Ian, Caldwell, John, Fonseca, Tatiana, Donald, Alastair, Bavetsias, Vassilios, Hunter, Lisa-Jane K., Garrett, Michelle D., Rowlands, Martin G., Aherne, G. Wynne, Davies, Thomas G., Berdini, Valerio, Woodhead, Steven J., Davis, Deborah, Seavers, Lisa C.A., Wyatt, Paul G., Workman, Paul, McDonald, Edward

“…Novel pyrrolidine-derived isoquinoline-5-sulfonamide inhibitors of PKB were designed, and investigated crystallographically and in cellular assays…”
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Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation by Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C. A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A. E, Jhoti, Harren

“…We describe the structure-guided optimization of the molecular fragments 2-amino-3-benzyloxypyridine 1 (IC50 1.3 mM) and 3-(2-(4-pyridyl)ethyl)indole 2 (IC50…”
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Identification of N -(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1 H -pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design by Wyatt, Paul G., Woodhead, Andrew J., Berdini, Valerio, Boulstridge, John A., Carr, Maria G., Cross, David M., Davis, Deborah J., Devine, Lindsay A., Early, Theresa R., Feltell, Ruth E., Lewis, E. Jonathan, McMenamin, Rachel L., Navarro, Eva F., O’Brien, Michael A., O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A., Smith, Donna-Michelle, Squires, Matt S., Trewartha, Gary, Walker, Margaret T., Woolford, Alison J.-A.

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Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation by Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A E, Jhoti, Harren

“…We describe the structure-guided optimization of the molecular fragments 2-amino-3-benzyloxypyridine 1 (IC(50) 1.3 mM) and 3-(2-(4-pyridyl)ethyl)indole 2…”
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