Search Results - "Seavers, A."

Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design by Wyatt, Paul G, Woodhead, Andrew J, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Davis, Deborah J, Devine, Lindsay A, Early, Theresa R, Feltell, Ruth E, Lewis, E. Jonathan, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A, Smith, Donna-Michelle, Squires, Matt S, Trewartha, Gary, Walker, Margaret T, Woolford, Alison J.-A

“…The application of fragment-based screening techniques to cyclin dependent kinase 2 (CDK2) identified multiple (>30) efficient, synthetically tractable small…”
Get full text

Successful use of topical mitomycin C for the treatment of a putative neoplastic vascular mass on the nictitating membrane of a dog by Seavers, A, Robson, D, Weingarth, JM

“…A nine‐year‐old female desexed Great Dane presented with a painful, proliferative, soft red putative neoplastic vascular mass on the nictitating membrane…”
Get full text

Association of a P2RX7 gene missense variant with brachycephalic dog breeds by Sophocleous, R. A., Sluyter, V., Curtis, B. L., Curtis, S. J., Jurak, L. M., Faulks, M., Spildrejorde, M., Gates, S., Proctor, E.‐J., Seavers, A., Watson, D., Kuit, T., Dowton, M., Stokes, L., Sluyter, R.

“…Summary Missense variants are associated with various phenotypic traits and disorders in dogs. The canine P2RX7 gene, coding the ATP‐gated P2X7 receptor ion…”
Get full text

Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors by Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W, Seavers, Lisa C. A, van Montfort, Rob L. M

“…The screening of fragments is an alternative approach to high-throughput screening for the identification of leads for therapeutic targets. Fragment hits have…”
Get full text

A vesicular (blistering) skin condition in a dog following putative contact exposure to Plumbago auriculata by Seavers, A, Robson, D, Weingarth, JM

“…Case report A 2‐year‐old male Airedale Terrier was presented with an acute and painful, predominantly ventral, vesicular skin eruption following putative…”
Get full text

Evaluation of the thyroid status of Basenji dogs in Australia [Erratum: 2009 Jan- Feb, v. 87, no. 1, p. 50-51.] by Seavers, A, Snow, D.H, Mason, K.V, Malik, R

“…Objective  To determine the thyroid status of Basenji dogs in Australia. Methods  Jugular or cephalic venipuncture blood samples were taken from 113 Basenji,…”
Get full text

Docking dispute by Seavers, A

Get full text

Cutaneous syndrome possibly caused by heartworm infestation in a dog by Seavers, A

“…A 9‐year‐old German Shepherd bitch was presented with a recent onset of seborrhoea oleosa, hyperpigmentation, erythema, pruritus and alopecia along the neck,…”
Get full text

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B by Collins, Ian, Caldwell, John, Fonseca, Tatiana, Donald, Alastair, Bavetsias, Vassilios, Hunter, Lisa-Jane K., Garrett, Michelle D., Rowlands, Martin G., Aherne, G. Wynne, Davies, Thomas G., Berdini, Valerio, Woodhead, Steven J., Davis, Deborah, Seavers, Lisa C.A., Wyatt, Paul G., Workman, Paul, McDonald, Edward

“…Novel pyrrolidine-derived isoquinoline-5-sulfonamide inhibitors of PKB were designed, and investigated crystallographically and in cellular assays…”
Get full text

Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation by Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C. A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A. E, Jhoti, Harren

“…We describe the structure-guided optimization of the molecular fragments 2-amino-3-benzyloxypyridine 1 (IC50 1.3 mM) and 3-(2-(4-pyridyl)ethyl)indole 2 (IC50…”
Get full text

Successful use of topical mitomycin C for the treatment of a putative neoplastic vascular mass on the nictitating membrane of a dog by Seavers, A, Robson, D, Weingarth, J M

Get full text

A vesicular (blistering) skin condition in a dog following putative contact exposure to Plumbago auriculata by Seavers, A, Robson, D, Weingarth, JM

Get full text

Cutaneous syndrome possibly caused by heartworm infestation in a dog by SEAVERS, A.

Get full text

Identification of N -(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1 H -pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design by Wyatt, Paul G., Woodhead, Andrew J., Berdini, Valerio, Boulstridge, John A., Carr, Maria G., Cross, David M., Davis, Deborah J., Devine, Lindsay A., Early, Theresa R., Feltell, Ruth E., Lewis, E. Jonathan, McMenamin, Rachel L., Navarro, Eva F., O’Brien, Michael A., O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A., Smith, Donna-Michelle, Squires, Matt S., Trewartha, Gary, Walker, Margaret T., Woolford, Alison J.-A.

Get full text

Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation by Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A E, Jhoti, Harren

“…We describe the structure-guided optimization of the molecular fragments 2-amino-3-benzyloxypyridine 1 (IC(50) 1.3 mM) and 3-(2-(4-pyridyl)ethyl)indole 2…”
Get full text