Search Results - "Sears, Sheila M.S."

Sexually dimorphic and brain region-specific transporter adaptations in system xc− null mice by Sosnoski, Heather M., Sears, Sheila M.S., He, Yan, Frare, Carla, Hewett, Sandra J.

“…System xc− is a heterodimeric amino acid antiporter that, in the central nervous system, is best known for linking the import of L-cystine (CySS) with the…”
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Decreased epileptogenesis in mice lacking the System xc− transporter occurs in association with a reduction in AMPA receptor subunit GluA1 by Sears, Sheila M. S., Hewett, James A., Hewett, Sandra J.

“…Summary Objective Although the cystine/glutamate antiporter System xc− (Sxc−) plays a permissive role in glioma‐associated seizures, its contribution to other…”
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Influence of glutamate and GABA transport on brain excitatory/inhibitory balance by Sears, Sheila MS, Hewett, Sandra J

“…An optimally functional brain requires both excitatory and inhibitory inputs that are regulated and balanced. A perturbation in the excitatory/inhibitory…”
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Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system xc by Sears, Sheila M. S., Roberts, Sarah H., Hewett, Sandra J.

“…System xc− (Sxc−) is a heteromeric antiporter (L‐cystine/L‐glutamate exchanger) expressed predominately on astrocytes in the central nervous system. Its…”
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