Search Results - "Sears, Pamela S"

Efficacy of Fidaxomicin Versus Vancomycin as Therapy for Clostridium difficile Infection in Individuals Taking Concomitant Antibiotics for Other Concurrent Infections by Mullane, Kathleen M., Miller, Mark A., Weiss, Karl, Lentnek, Arnold, Golan, Yoav, Sears, Pamela S., Shue, Youe-Kong, Louie, Thomas J., Gorbach, Sherwood L.

“…Background. Treatment guidelines recommend stopping all implicated antibiotics at the onset of Clostridium difficile infection (CDI), but many individuals have…”
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Decreased Cure and Increased Recurrence Rates for Clostridium difficile Infection Caused by the Epidemic C. difficile BI Strain by Petrella, Laurica A., Sambol, Susan P., Cheknis, Adam, Nagaro, Kristin, Kean, Yin, Sears, Pamela S., Babakhani, Farah, Johnson, Stuart, Gerding, Dale N.

“…Background. An epidemic strain of Clostridium difficile designated by restriction endonuclease analysis (REA) as group BI has caused multiple outbreaks of…”
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A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile-associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation by Mullane, Kathleen M, Winston, Drew J, Nooka, Ajay, Morris, Michele I, Stiff, Patrick, Dugan, Michael J, Holland, Henry, Gregg, Kevin, Adachi, Javier A, Pergam, Steven A, Alexander, Barbara D, Dubberke, Erik R, Broyde, Natalya, Gorbach, Sherwood L, Sears, Pamela S

“…Patients undergoing hematopoietic stem cell transplantation are at elevated risk for development of Clostridium difficile-associated diarrhea (CDAD)…”
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Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections by Li, Dan, Sabato, Philip E, Guiastrennec, Benjamin, Ouerdani, Aziz, Feng, Hwa-Ping, Duval, Vincent, De Anda, Carisa S, Sears, Pamela S, Chou, Margaret Z, Hardalo, Catherine, Broyde, Natalya, Rizk, Matthew L

“…Tedizolid phosphate is an oxazolidinone antibacterial agent approved for the treatment of Gram-positive acute bacterial skin and skin structure infections…”
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Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age by Arrieta, Antonio C., Ang, Jocelyn Y., Espinosa, Claudia, Fofanov, Oleksandr, Tøndel, Camilla, Chou, Margaret Z., De Anda, Carisa S., Kim, Jason Y., Li, Dan, Sabato, Philip, Sears, Pamela S., Bradley, John S.

“…Infections with Gram-positive bacteria, including acute bacterial skin and skin structure infections (ABSSSIs), are common in children. We describe a…”
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Molnupiravir for intra-household prevention of COVID-19: The MOVe-AHEAD randomized, placebo-controlled trial by Alpizar, Sady A., Accini, Jose, Anderson, Duane C., Eysa, Basem, Medina-Piñón, Isaí, Ohmagari, Norio, Ostrovskyy, Mykola M., Aggrey-Amable, Angela, Beck, Karen, Byrne, Dana, Grayson, Staci, Hwang, Peggy M.T., Lonchar, Julia D., Strizki, Julie, Xu, Yayun, Paschke, Amanda, De Anda, Carisa S., Sears, Pamela S.

“…To evaluate the efficacy and safety of molnupiravir for intra-household post-exposure prophylaxis (PEP) of COVID-19. MOVe-AHEAD was a randomized, controlled,…”
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Safety and Efficacy of Oral and/or Intravenous Tedizolid Phosphate From a Randomized Phase 3 Trial in Adolescents With Acute Bacterial Skin and Skin Structure Infections by Bradley, John S., Antadze, Tinatin, Ninov, Borislav, Tayob, Mohammed S., Broyde, Natasha, Butterton, Joan R., Chou, Margaret Z., De Anda, Carisa S., Kim, Jason Y., Sears, Pamela S.

“…Tedizolid phosphate is an oxazolidinone prodrug approved in 2014 for treatment of adults with acute bacterial skin and skin structure infections (ABSSSIs);…”
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An Efficient Chemoenzymatic Strategy for the Synthesis of Wild-Type and Vancomycin-Resistant Bacterial Cell-Wall Precursors:  UDP-N-acetylmuramyl-peptides by Liu, Haitian, Sadamoto, Reiko, Sears, Pamela S, Wong, Chi-Huey

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Design and Synthesis of New Aminoglycoside Antibiotics Containing Neamine as an Optimal Core Structure:  Correlation of Antibiotic Activity with in Vitro Inhibition of Translation by Greenberg, William A, Priestley, E. Scott, Sears, Pamela S, Alper, Phil B, Rosenbohm, Christoph, Hendrix, Martin, Hung, Shang-Cheng, Wong, Chi-Huey

“…The structure and activity of the pseudodisaccharide core found in aminoglycoside antibiotics was probed with a series of synthetic analogues in which the…”
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High Fecal and Low Plasma Levels of Fidaxomicin and Metabolite OP-1118 in Patients With C. difficile Infection: Combined Results of Two Phase 3 Trials by Sears, Pamela S, Crook, Derrick W, Louie, Thomas J, Miller, Mark, Weiss, Karl

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Risk of Recurrence and Time to Recurrence Following Treatment of Clostridium difficile Infection: Patient Characteristics and the Differential Effect of Fidaxomicin vs. Vancomycin by Golan, Yoav, Louie, Thomas J, Miller, Mark, Mullane, Kathleen M, Weiss, Karl, Lentnek, Arnold, Robinson, James M, Sears, Pamela S, Shue, Youe-Kong, Gorbach, Sherwood L

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Dimeric Aminoglycosides as Antibiotics by Agnelli, Fabio, Sucheck, Steven J., Marby, Kenneth A., Rabuka, David, Yao, Su-Lan, Sears, Pamela S., Liang, Fu-Sen, Wong, Chi-Huey

“…Double duty: Dimeric aminoglycoside antibiotics were designed by linking neamine or nebramine cores with various tethers differing in length and composition…”
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Cell-Wall Engineering of Living Bacteria by Sadamoto, Reiko, Niikura, Kenichi, Sears, Pamela S, Liu, Haitian, Wong, Chi-Huey, Suksomcheep, Akarat, Tomita, Fusao, Monde, Kenji, Nishimura, Shin-Ichiro

“…The cell walls of living bacteria were chemically modified by adding cell-wall precursors. As the precursors to be incorporated into the cell wall, UDP-MurNAc…”
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Acceptor Specificity and Inhibition of the Bacterial Cell-Wall Glycosyltransferase MurG by Liu, Haitian, Ritter, Thomas K, Sadamoto, Reiko, Sears, Pamela S, Wu, Min, Wong, Chi-Huey

“…A continuous fluorescence coupled enzyme assay was developed to study the acceptor specificity of the glycosyltransferase MurG toward different lipid I…”
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Synthesis of Solid-Supported Mirror-Image Sugars: A Novel Method for Selecting Receptors for Cellular-Surface Carbohydrates by Kozlov, Igor A., Mao, Shenlan, Xu, Yue, Huang, Xuefei, Lee, Lac, Sears, Pamela S., Gao, Changshou, Coyle, Avery R., Janda, Kim D., Wong, Chi-Huey

“…We introduced a novel method, through mirror‐image phage display, for the identification of high‐affinity D‐peptides to target specific cell‐surface…”
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Safety and Efficacy of Oral and/or Intravenous Tedizolid Phosphate From a Randomized Phase 3 Trial in Adolescents With Acute Bacterial Skin and Skin Structure Infections by Bradley, John S., Antadze, Tinatin, Ninov, Borislav, Tayob, Mohammed S., Broyde, Natasha, Butterton, Joan R., Chou, Margaret Z., De Anda, Carisa S., Kim, Jason Y., Sears, Pamela S.

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471. Safety and Efficacy of Oral and/or Intravenous Tedizolid Phosphate (TZD) in Adolescents with Acute Bacterial Skin and Skin Structure Tissue Infections (ABSSSI) by Bradley, John S, Antadze, Tinatin, Mitha, Ismail H, Ninov, Borislav, Tayob, Mohammed S, Broyde, Natasha, Butterton, Joan R, Chou, Margaret Z, De Anda, Carisa S, Kim, Jason Y, Sears, Pamela S

“…Abstract Background Tedizolid phosphate has activity against gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, and was approved…”
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Dimeric Aminoglycosides as Antibiotics by Agnelli, Fabio, Sucheck, Steven J., Marby, Kenneth A., Rabuka, David, Yao, Su-Lan, Sears, Pamela S., Liang, Fu-Sen, Wong, Chi-Huey

“…Doppeltes Spiel: Dimere Aminoglycosid‐Antibiotika wurden durch Verknüpfung von Neamin‐ oder Nebramin‐Kernen mit Linkern unterschiedlicher Länge und…”
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Biological and immunological characterization of cleaved and 16K forms of rat prolactin by Clapp, C, Sears, P S, Russell, D H, Richards, J, Levay-Young, B K, Nicoll, C S

“…A cleaved form of rat PRL (rPRL) has been reported to exist in the pituitary gland and to be the main product of PRL proteolysis by its target tissues. A 16K…”
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Binding studies with intact rat prolactin and a 16K fragment of the hormone by Clapp, C, Sears, P S, Nicoll, C S

“…A cleaved form of PRL has been found in the pituitary of rodents and humans and in human blood. A 16K fragment derived from cleaved rat (r) PRL has mitogenic…”
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