Search Results - "Sears, Pamela"

Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial by Cornely, Oliver A, Prof, Crook, Derrick W, Prof, Esposito, Roberto, Prof, Poirier, André, MD, Somero, Michael S, MD, Weiss, Karl, Prof, Sears, Pamela, PhD, Gorbach, Sherwood, Prof

“…Summary Background Infection with Clostridium difficile is the primary infective cause of antibiotic-associated diarrhoea. We aimed to compare efficacy and…”
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Efficacy of Fidaxomicin Versus Vancomycin as Therapy for Clostridium difficile Infection in Individuals Taking Concomitant Antibiotics for Other Concurrent Infections by Mullane, Kathleen M., Miller, Mark A., Weiss, Karl, Lentnek, Arnold, Golan, Yoav, Sears, Pamela S., Shue, Youe-Kong, Louie, Thomas J., Gorbach, Sherwood L.

“…Background. Treatment guidelines recommend stopping all implicated antibiotics at the onset of Clostridium difficile infection (CDI), but many individuals have…”
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Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis by Artsimovitch, Irina, Seddon, Jaime, Sears, Pamela

“…Fidaxomicin was recently approved for the treatment of Clostridium difficile infection. It inhibits transcription by bacterial RNA polymerase. Because…”
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Decreased Cure and Increased Recurrence Rates for Clostridium difficile Infection Caused by the Epidemic C. difficile BI Strain by Petrella, Laurica A., Sambol, Susan P., Cheknis, Adam, Nagaro, Kristin, Kean, Yin, Sears, Pamela S., Babakhani, Farah, Johnson, Stuart, Gerding, Dale N.

“…Background. An epidemic strain of Clostridium difficile designated by restriction endonuclease analysis (REA) as group BI has caused multiple outbreaks of…”
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Fidaxomicin Inhibits Spore Production in Clostridium difficile by Babakhani, Farah, Bouillaut, Laurent, Gomez, Abraham, Sears, Pamela, Nguyen, Ly, Sonenshein, Abraham L.

“…Fidaxomicin (FDX) is a novel antimicrobial agent with narrow-spectrum and potent bactericidal activity against Clostridium difficile. In recent clinical…”
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Postantibiotic Effect of Fidaxomicin and Its Major Metabolite, OP-1118, against Clostridium difficile by BABAKHANI, Farah, GOMEZ, Abraham, ROBERT, Nikki, SEARS, Pamela

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Comparative Microbiological Studies of Transcription Inhibitors Fidaxomicin and the Rifamycins in Clostridium difficile by BABAKHANI, Farah, SEDDON, Jaime, SEARS, Pamela

“…Fidaxomicin (FDX) is a narrow-spectrum antibiotic for the treatment of Clostridium difficile-associated diarrhea. While FDX and rifamycins share the same…”
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A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile-associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation by Mullane, Kathleen M, Winston, Drew J, Nooka, Ajay, Morris, Michele I, Stiff, Patrick, Dugan, Michael J, Holland, Henry, Gregg, Kevin, Adachi, Javier A, Pergam, Steven A, Alexander, Barbara D, Dubberke, Erik R, Broyde, Natalya, Gorbach, Sherwood L, Sears, Pamela S

“…Patients undergoing hematopoietic stem cell transplantation are at elevated risk for development of Clostridium difficile-associated diarrhea (CDAD)…”
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Killing kinetics of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile by Babakhani, Farah, Gomez, Abraham, Robert, Nikki, Sears, Pamela

“…The kinetics of bacterial killing for fidaxomicin and its major metabolite, OP-1118, were investigated against Clostridium difficile strains, including two…”
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Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections by Li, Dan, Sabato, Philip E, Guiastrennec, Benjamin, Ouerdani, Aziz, Feng, Hwa-Ping, Duval, Vincent, De Anda, Carisa S, Sears, Pamela S, Chou, Margaret Z, Hardalo, Catherine, Broyde, Natalya, Rizk, Matthew L

“…Tedizolid phosphate is an oxazolidinone antibacterial agent approved for the treatment of Gram-positive acute bacterial skin and skin structure infections…”
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Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age by Arrieta, Antonio C., Ang, Jocelyn Y., Espinosa, Claudia, Fofanov, Oleksandr, Tøndel, Camilla, Chou, Margaret Z., De Anda, Carisa S., Kim, Jason Y., Li, Dan, Sabato, Philip, Sears, Pamela S., Bradley, John S.

“…Infections with Gram-positive bacteria, including acute bacterial skin and skin structure infections (ABSSSIs), are common in children. We describe a…”
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Molnupiravir for intra-household prevention of COVID-19: The MOVe-AHEAD randomized, placebo-controlled trial by Alpizar, Sady A., Accini, Jose, Anderson, Duane C., Eysa, Basem, Medina-Piñón, Isaí, Ohmagari, Norio, Ostrovskyy, Mykola M., Aggrey-Amable, Angela, Beck, Karen, Byrne, Dana, Grayson, Staci, Hwang, Peggy M.T., Lonchar, Julia D., Strizki, Julie, Xu, Yayun, Paschke, Amanda, De Anda, Carisa S., Sears, Pamela S.

“…To evaluate the efficacy and safety of molnupiravir for intra-household post-exposure prophylaxis (PEP) of COVID-19. MOVe-AHEAD was a randomized, controlled,…”
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Safety and Efficacy of Oral and/or Intravenous Tedizolid Phosphate From a Randomized Phase 3 Trial in Adolescents With Acute Bacterial Skin and Skin Structure Infections by Bradley, John S., Antadze, Tinatin, Ninov, Borislav, Tayob, Mohammed S., Broyde, Natasha, Butterton, Joan R., Chou, Margaret Z., De Anda, Carisa S., Kim, Jason Y., Sears, Pamela S.

“…Tedizolid phosphate is an oxazolidinone prodrug approved in 2014 for treatment of adults with acute bacterial skin and skin structure infections (ABSSSIs);…”
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Comparative Susceptibilities to Fidaxomicin (OPT-80) of Isolates Collected at Baseline, Recurrence, and Failure from Patients in Two Phase III Trials of Fidaxomicin against Clostridium difficile Infection by GOLDSTEIN, Ellie J. C, CITRON, Diane M, SEARS, Pamela, BABAKHANI, Farah, SAMBOL, Susan P, GERDING, Dale N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Toward Automated Synthesis of Oligosaccharides and Glycoproteins by Sears, Pamela, Wong, Chi-Huey

“…The discovery of previously unknown functions associated with carbohydrates and the study of their structure-function relations are of current interest in…”
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Carbohydrate Mimetics: A New Strategy for Tackling the Problem of Carbohydrate-Mediated Biological Recognition by Sears, Pamela, Wong, Chi-Huey

“…Useful strategies for the design of molecules to mimic carbohydrates have been developed over the past few years. Mimics of the target may contain new…”
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Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice by Lin, Qianyun, Li, Zitong, Lu, Lei, Xu, Hua, Lou, Eddie, Chen, Alyssa, Sun, Dustin, Zhang, Wuyi, Zhu, Weishu, Yee, Eric U., Sears, Pamela Suzanne, Chen, Xinhua, Kelly, Ciaran P.

“…Clostridioides difficile infection (CDI) induces intense acute inflammatory responses through toxin release. A combination of antibiotic and anti-inflammatory…”
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Design and Synthesis of New Aminoglycoside Antibiotics Containing Neamine as an Optimal Core Structure:  Correlation of Antibiotic Activity with in Vitro Inhibition of Translation by Greenberg, William A, Priestley, E. Scott, Sears, Pamela S, Alper, Phil B, Rosenbohm, Christoph, Hendrix, Martin, Hung, Shang-Cheng, Wong, Chi-Huey

“…The structure and activity of the pseudodisaccharide core found in aminoglycoside antibiotics was probed with a series of synthetic analogues in which the…”
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High Fecal and Low Plasma Levels of Fidaxomicin and Metabolite OP-1118 in Patients With C. difficile Infection: Combined Results of Two Phase 3 Trials by Sears, Pamela S, Crook, Derrick W, Louie, Thomas J, Miller, Mark, Weiss, Karl

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Risk of Recurrence and Time to Recurrence Following Treatment of Clostridium difficile Infection: Patient Characteristics and the Differential Effect of Fidaxomicin vs. Vancomycin by Golan, Yoav, Louie, Thomas J, Miller, Mark, Mullane, Kathleen M, Weiss, Karl, Lentnek, Arnold, Robinson, James M, Sears, Pamela S, Shue, Youe-Kong, Gorbach, Sherwood L

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