Search Results - "Sears, Karen E"

Unraveling the heritage of lost traits by Sadier, Alexa, Sears, Karen E., Womack, Molly

“…We synthesize ontogenetic work spanning the past century that show evolutionarily lost structures are rarely entirely absent from earlier developmental stages…”
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Developmental influence on evolutionary rates and the origin of placental mammal tooth complexity by Couzens, Aidan M. C., Sears, Karen E., Rücklin, Martin

“…Development has often been viewed as a constraining force on morphological adaptation, but its precise influence, especially on evolutionary rates, is poorly…”
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Patterning and post-patterning modes of evolutionary digit loss in mammals by Cooper, Kimberly L., Sears, Karen E., Uygur, Aysu, Maier, Jennifer, Baczkowski, Karl-Stephan, Brosnahan, Margaret, Antczak, Doug, Skidmore, Julian A., Tabin, Clifford J.

“…A reduction in the number of digits has evolved many times in tetrapods, particularly in cursorial mammals that travel over deserts and plains, yet the…”
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Bat teeth illuminate the diversification of mammalian tooth classes by Sadier, Alexa, Anthwal, Neal, Krause, Andrew L., Dessalles, Renaud, Lake, Michael, Bentolila, Laurent A., Haase, Robert, Nieves, Natalie A., Santana, Sharlene E., Sears, Karen E.

“…Tooth classes are an innovation that has contributed to the evolutionary success of mammals. However, our understanding of the mechanisms by which tooth…”
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On the serial homology of the pectoral and pelvic girdles of tetrapods by Sears, Karen E., Capellini, Terence D., Diogo, Rui

“…While fore- and hindlimbs are commonly assumed to be serially homologous, the serial homology of the pectoral and pelvic girdles is more ambiguous. We…”
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A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw by Urban, Daniel J., Anthwal, Neal, Luo, Zhe-Xi, Maier, Jennifer A., Sadier, Alexa, Tucker, Abigail S., Sears, Karen E.

“…Multiple mammalian lineages independently evolved a definitive mammalian middle ear (DMME) through breakdown of Meckel's cartilage (MC). However, the cellular…”
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Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci by Sugrue, Victoria J, Zoller, Joseph Alan, Narayan, Pritika, Lu, Ake T, Ortega-Recalde, Oscar J, Grant, Matthew J, Bawden, C Simon, Rudiger, Skye R, Haghani, Amin, Bond, Donna M, Hore, Reuben R, Garratt, Michael, Sears, Karen E, Wang, Nan, Yang, Xiangdong William, Snell, Russell G, Hore, Timothy A, Horvath, Steve

“…In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic…”
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Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development by Anthwal, Neal, Urban, Daniel J, Sadier, Alexa, Takenaka, Risa, Spiro, Simon, Simmons, Nancy, Behringer, Richard R, Cretekos, Chris J, Rasweiler, 4th, John J, Sears, Karen E

“…Through the evolution of novel wing structures, bats (Order Chiroptera) became the only mammalian group to achieve powered flight. This achievement preceded…”
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Evaluating the performance of targeted sequence capture, RNA‐Seq, and degenerate‐primer PCR cloning for sequencing the largest mammalian multigene family by Yohe, Laurel R., Davies, Kalina T. J., Simmons, Nancy B., Sears, Karen E., Dumont, Elizabeth R., Rossiter, Stephen J., Dávalos, Liliana M.

“…Multigene families evolve from single‐copy ancestral genes via duplication, and typically encode proteins critical to key biological processes. Molecular…”
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Review and experimental evaluation of the embryonic development and evolutionary history of flipper development and hyperphalangy in dolphins (Cetacea: Mammalia) by Cooper, Lisa Noelle, Sears, Karen E., Armfield, Brooke A., Kala, Bhavneet, Hubler, Merla, Thewissen, J. G. M.

“…Summary Cetaceans are the only mammals to have evolved hyperphalangy, an increase in the number of phalanges beyond the mammalian plesiomorphic condition of…”
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Limb development: a paradigm of gene regulation by Petit, Florence, Sears, Karen E., Ahituv, Nadav

“…Key Points The limb is widely used as a model in developmental biology. Although the signalling pathways involved in limb development are largely conserved,…”
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A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis by de Guzman Strong, Cristina, Conlan, Sean, Deming, Clayton B., Cheng, Jun, Sears, Karen E., Segre, Julia A.

“…Two common inflammatory skin disorders with impaired barrier, atopic dermatitis (AD) and psoriasis, share distinct genetic linkage to the Epidermal…”
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Multifactorial processes underlie parallel opsin loss in neotropical bats by Sadier, Alexa, Davies, Kalina Tj, Yohe, Laurel R, Yun, Kun, Donat, Paul, Hedrick, Brandon P, Dumont, Elizabeth R, Dávalos, Liliana M, Rossiter, Stephen J, Sears, Karen E

“…The loss of previously adaptive traits is typically linked to relaxation in selection, yet the molecular steps leading to such repeated losses are rarely…”
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Making a bat: The developmental basis of bat evolution by Sadier, Alexa, Urban, Daniel J, Anthwal, Neal, Howenstine, Aidan O, Sinha, Ishani, Sears, Karen E

“…Bats are incredibly diverse, both morphologically and taxonomically. Bats are the only mammalian group to have achieved powered flight, an adaptation that is…”
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The significance and scope of evolutionary developmental biology: a vision for the 21st century by Moczek, Armin P., Sears, Karen E., Stollewerk, Angelika, Wittkopp, Patricia J., Diggle, Pamela, Dworkin, Ian, Ledon-Rettig, Cristina, Matus, David Q., Roth, Siegfried, Abouheif, Ehab, Brown, Federico D., Chiu, Chi-Hua, Cohen, C. Sarah, Tomaso, Anthony W. De, Gilbert, Scott F., Hall, Brian, Love, Alan C., Lyons, Deirdre C., Sanger, Thomas J., Smith, Joel, Specht, Chelsea, Vallejo-Marin, Mario, Extavour, Cassandra G.

“…SUMMARY Evolutionary developmental biology (evo‐devo) has undergone dramatic transformations since its emergence as a distinct discipline. This paper aims to…”
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Development of Bat Flight: Morphologic and Molecular Evolution of Bat Wing Digits by Sears, Karen E., Behringer, Richard R., Rasweiler, John J., Niswander, Lee A.

“…The earliest fossil bats resemble their modern counterparts in possessing greatly elongated digits to support the wing membrane, which is an anatomical…”
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Differences in Growth Generate the Diverse Palate Shapes of New World Leaf-Nosed Bats (Order Chiroptera, Family Phyllostomidae) by Sears, Karen E.

“…New World leaf-nosed bats (Family Phyllostomidae) display incredible craniofacial diversity that is associated with their broad range of dietary preferences…”
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The Relationship between Gene Network Structure and Expression Variation among Individuals and Species by Sears, Karen E, Maier, Jennifer A, Rivas-Astroza, Marcelo, Poe, Rachel, Zhong, Sheng, Kosog, Kari, Marcot, Jonathan D, Behringer, Richard R, Cretekos, Chris J, Rasweiler, 4th, John J, Rapti, Zoi

“…Variation among individuals is a prerequisite of evolution by natural selection. As such, identifying the origins of variation is a fundamental goal of…”
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Meckel’s cartilage breakdown offers clues to mammalian middle ear evolution by Anthwal, Neal, Urban, Daniel J., Luo, Zhe-Xi, Sears, Karen E., Tucker, Abigail S.

“…A key transformation in mammalian ear evolution was incorporation of the primary jaw joint of premammalian synapsids into the definitive mammalian middle ear…”
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The evolution and development of mammalian flight by Cooper, Lisa Noelle, Cretekos, Chris J, Sears, Karen E

“…Mammals have evolved a stunning diversity of limb morphologies (e.g., wings, flippers, hands, and paws) that allowed access to a wide range of habitats. Over…”
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