Search Results - "Sears, H F"

Human Anti-Idiotype Antibodies in Cancer Patients: Is the Modulation of the Immune Response Beneficial for the Patient? by Koprowski, Hilary, Herlyn, Dorothee, Lubeck, Michael, DeFreitas, Elaine, Sears, Henry F.

“…Inoculation of human subjects with mouse monoclonal antibody results in the production of anti-idiotype antibody that reacts with the binding site of the…”
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Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments by Moldofsky, P J, Powe, J, Mulhern, Jr, C B, Hammond, N, Sears, H F, Gatenby, R A, Steplewski, Z, Koprowski, H

“…Nine patients with colonic carcinoma were studied with I-131-labeled F(ab')2 fragments of an anti-colorectal carcinoma monoclonal antibody. A total of 69% of…”
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Characterization of Lewis Antigens in Normal Colon and Gastrointestinal Adenocarcinomas by Blaszczyk, Magdalena, Pak, Koon Yan, Herlyn, Meenhard, Sears, Henry F., Steplewski, Zenon

“…The Lewis a antigen (Lea)- and Lewis b antigen (Leb)-active glycolipids and glycoproteins in normal colon mucosa, colon carcinoma tumors, and gastrointestinal…”
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The expression of colorectal carcinoma-associated antigens in the normal colonic mucosa. An immunohistochemical analysis of regional distribution by Wolf, BC, Salem, RR, Sears, HF, Horst, DA, Lavin, PT, Herlyn, M, Itzkowitz, SH, Schlom, J, Steele, GD, Jr

“…Immunohistologic studies were performed to evaluate the expression and regional distribution of 20 colorectal carcinoma-associated antigens in the colonic…”
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Evidence that c-myc expression defines two genetically distinct forms of colorectal adenocarcinoma by ROTHBERG, P. G, SPANDORFER, J. M, ERISMAN, M. D, STAROSCIK, R. N, SEARS, H. F, PETERSEN, R. O, ASTRIN, S. M

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A radioimmunoassay for the detection of a human tumor-associated glycoprotein (TAG-72) using monoclonal antibody B72.3 by Paterson, A J, Schlom, J, Sears, H F, Bennett, J, Colcher, D

“…Monoclonal antibody (MAb) B72.3 was generated against a carcinoma metastasis and has been shown to bind with a high degree of selectivity to a tumor-associated…”
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Detection of the tumor-associated glycoprotein antigen (TAG-72) in premalignant lesions of the colon by Wolf, B C, D'Emilia, J C, Salem, R R, DeCoste, D, Sears, H F, Gottlieb, L S, Steele, Jr, G D

“…We used monoclonal antibody B72.3 to study the expression of the colorectal carcinoma-associated antigen TAG-72 in premalignant colonic lesions with the…”
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Initial clinical evaluation of two murine IgG2a monoclonal antibodies for immunotherapy of gastrointestinal carcinoma by Herlyn, D, Sears, H F, Ernst, C S, Iliopoulos, D, Steplewski, Z, Koprowski, H

“…Eleven patients with advanced gastrointestinal (GI) carcinoma were entered in Phase I initial clinical trials with IgG2a antiGI carcinoma monoclonal antibodies…”
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Expression of colorectal carcinoma-associated antigens in colonic polyps by Salem, R R, Wolf, B C, Sears, H F, Lavin, P T, Ravikumar, T S, DeCoste, D, D'Emilia, J C, Herlyn, M, Schlom, J, Gottlieb, L S

“…Immunohistologic techniques were used to study the expression of colorectal carcinoma-associated antigens in colonic polyps and to compare this with expression…”
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Usefulness and technique of axillary dissection in primary breast cancer by Cady, B, Sears, H F

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Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal-antibody imaging by Moldofsky, P J, Sears, H F, Mulhern, Jr, C B, Hammond, N D, Powe, J, Gatenby, R A, Steplewski, Z, Koprowski, H

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Binding of murine immunoglobulin to human tissues after immunotherapy with anticolorectal carcinoma monoclonal antibody by Shen, J W, Atkinson, B, Koprowski, H, Sears, H F

“…An anticolorectal carcinoma antibody, 17-IA, that is of gamma 2a isotype and has been used in previous immunotherapy trials, binds to an antigen on most human…”
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Increased sensitivity in detecting tumor-associated antigens in sera of patients with colorectal carcinoma by Herlyn, M, Sears, H F, Verrill, H, Koprowski, H

“…A monoclonal antibody defining the Lewis blood group determinant was used to immobilize antigen in sera of patients with adenocarcinoma of the gastrointestinal…”
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Phase II clinical trial of a murine monoclonal antibody cytotoxic for gastrointestinal adenocarcinoma by SEARS, H. F, HERLYN, D, STEPLEWSKI, Z, KOPROWSKI, H

“…A murine monoclonal antibody (MAb) which binds to human metastatic gastrointestinal adenocarcinomas can be administered safely and has tumor effects in some…”
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Prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas by Rosenberg, S A, Kent, H, Costa, J, Webber, B L, Young, R, Chabner, B, Baker, A R, Brennan, M F, Chretien, P B, Cohen, M H, deMoss, E V, Sears, H F, Seipp, C, Simon, R

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Selection of monoclonal antibodies detecting serodiagnostic human tumor markers by Herlyn, M, Blaszczyk, M, Bennicelli, J, Sears, H F, Ernst, C, Ross, A H, Koprowski, H

“…Monoclonal antibodies (MAbs) were selected for specific binding to spent media of cultured tumor cells. Out of more than 12,000 hybridomas screened, 19 were…”
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A cell surface glycoprotein expressed by colorectal carcinomas including poorly differentiated, noncarcinoembryonic antigen-producing colorectal tumors by SALEM, R. R, WOLF, B. C, SEARS, H. F, THOMAS, P, BOLLINGER, B, ZAMCHECK, N, SARAVIS, C. A, LAN BO CHEN, STEELE, G. JR

“…A monoclonal antibody to a cell surface glycoprotein on human colorectal carcinomas was raised using the undifferentiated colon carcinoma cell line MIP 101 as…”
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Detection of a circulating gastrointestinal cancer antigen in sera of patients with gastrointestinal malignancies by a double determinant immunoassay with monoclonal antibodies against human blood group determinants by Herlyn, M, Shen, J W, Sears, H F, Civin, C I, Verrill, H L, Goldberg, E M, Koprowski, H

“…Monoclonal antibodies (MoAbs) produced against determinants A and B of the human ABO blood group system and against the Lea and Leb determinants of the Lewis…”
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Bilateral breast carcinoma: prospective evaluation of factors assisting diagnosis by Sears, H F, Janus, C, McDermott, A, Grotzinger, P

“…Bilateral primary breast cancers occur commonly enough to justify adoption of special pre- and post-initial therapy screening. A 13.2% incidence of bilateral…”
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Specific Antigen in Serum of Patients with Colon Carcinoma by Koprowski, Hilary, Herlyn, Meenhard, Steplewski, Zenon, Sears, Henry F.

“…The binding of monoclonal antibody specific for colon carcinoma was inhibited by serum from patients with adenocarcinoma of the colon but not by serum from…”
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