Search Results - "Sears, C L"

The Emerging Clinical Importance of Non-O157 Shiga Toxin—Producing Escherichia coli by Hughes, James M., Wilson, Mary E., Johnson, Kristine E., Thorpe, Cheleste M., Sears, Cynthia L.

“…In 1982, hemorrhagic colitis and hemolytic-uremic syndrome were linked to infection with Escherichia coli O157:H7, a serotype now classified as Shiga…”
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Persistent Diarrhea Signals a Critical Period of Increased Diarrhea Burdens and Nutritional Shortfalls: A Prospective Cohort Study among Children in Northeastern Brazil by Lima, A. A. M., Moore, S. R., Barboza, M. S., Soares, A. M., Schleupner, M. A., Newman, R. D., Sears, C. L., Nataro, J. P., Fedorko, D. P., Wuhib, T., Schorling, J. B., Guerrant, R. L.

“…Persistent diarrhea (PD; duration ⩾14 days) is a growing part of the global burden of diarrheal diseases. A 45-month prospective cohort study (with illness,…”
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Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease by Hourigan, S. K., Chen, L. A., Grigoryan, Z., Laroche, G., Weidner, M., Sears, C. L., Oliva‐Hemker, M.

“…Summary Background Little data are available regarding the effectiveness and associated microbiome changes of faecal microbiota transplantation (FMT) for…”
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Serum Mannose-Binding Lectin Deficiency Is Associated with Cryptosporidiosis in Young Haitian Children by Kirkpatrick, B. D., Huston, C. D., Wagner, D., Noel, F., Rouzier, P., Pape, J. W., Bois, G., Larsson, C. J., Alston, W. K., Tenney, K., Powden, C., O'Neill, J. P., Sears, C. L.

“…Background. Mannose-binding lectin (MBL) is a component of the innate immune response and binds microbial surfaces through carbohydrate recognition domains…”
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The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis by Thiele Orberg, E, Fan, H, Tam, A J, Dejea, C M, Destefano Shields, C E, Wu, S, Chung, L, Finard, B B, Wu, X, Fathi, P, Ganguly, S, Fu, J, Pardoll, D M, Sears, C L, Housseau, F

“…Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17…”
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Cryptosporidiosis in Patients with AIDS: Correlates of Disease and Survival by Manabe, Yukari C., Clark, Douglas P., Moore, Richard D., Lumadue, Dahlman, Holly R., Belitsos, Peter C., Chaisson, Richard E., Sears, Cynthia L.

“…Although 10%–15% of patients with AIDS in the United States may acquire cryptosporidium infection, little data exist on clinical or histological…”
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T84 cells in culture as a model for enteroaggregative Escherichia coli pathogenesis by NATARO, J. P, HICKS, S, PHILLIPS, A. D, VIAL, P. A, SEARS, C. L

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Longitudinal Study of Cryptosporidium Infection in Children in Northeastern Brazil by Newman, Robert D., Sears, Cynthia L., Moore, Sean R., Nataro, James P., Wuhib, Tadesse, Agnew, Deborah A., Guerrant, Richard L., Lima, Aldo A. M.

“…A prospective, 4-year cohort study of children born in an urban slum in northeastern Brazil was undertaken to elucidate the epidemiology of Cryptosporidium…”
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Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene by FRANCO, A. A, MUNDY, L. M, TRUCKSIS, M, WU, S, KAPER, J. B, SEARS, C. L

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Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis by KOSHY, S. S, MONTROSE, M. H, SEARS, C. L

“…Enterotoxigenic Bacteroides fragilis (ETBF) cells produce a 20-kDa heat-labile metalloprotease toxin which is potentially important in the pathogenesis of…”
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Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro by CHAMBERS, F. G, KOSHY, S. S, SAIDI, R. F, CLARK, D. P, MOORE, R. D, SEARS, C. L

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Detection of Toxin Production by Bacteroides fragilis: Assay Development and Screening of Extraintestinal Clinical Isolates by Mundy, Linda M., Sears, Cynthia L.

“…Strains of Bacteroides fragilis that produce an extracellular 20-kD heat-labile toxin have been epidemiologically associated with diarrheal disease. To…”
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A clinicopathologic analysis of AIDS-related cryptosporidiosis by LUMADUE, J. A, MANABE, Y. C, MOORE, R. D, BELITSOS, P. C, SEARS, C. L, CLARK, D. P

“…To characterize the histology of AIDS-associated cryptosporidiosis and identify features that explain the clinical variability. A retrospective analysis of…”
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Cloning, characterization, and chromosomal mapping of a phospholipase (lecithinase) produced by Vibrio cholerae by FIORE, A. E, MICHALSKI, J. M, RUSSELL, R. G, SEARS, C. L, KAPER, J

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Cryptosporidiosis in Northeastern Brazilian Children: Association with Increased Diarrhea Morbidity by Agnew, Deborah G., Lima, Aldo A. M., Newman, Robert D., Wuhib, Tadesse, Moore, Richard D., Guerrant, Richard L., Sears, Cynthia L.

“…To evaluate the impact of Cryptosporidium infection on diarrheal disease burden and nutrition status, a nested case-control study was done among children who…”
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Identification of a Third Metalloprotease Toxin Gene in Extraintestinal Isolates of Bacteroides fragilis by CHUNG, G.-T, FRANCO, A. A, SHAOGUANG WU, RHIE, G.-E, CHENG, R, OH, H.-B, SEARS, C. L

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Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro by SAIDI, R. F, SEARS, C. L

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The toxins of Bacteroides fragilis by Sears, Cynthia L.

“…Bacteroides fragilis are both key commensals and important human pathogens. Particular strains of B. fragilis, termed enterotoxigenic B. fragilis (ETBF), are…”
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Household epidemiology of Cryptosporidium parvum infection in an urban community in Northeast Brazil by NEWMAN, R. D, SHU-XIAN ZU, WUHIB, T, LIMA, A. A. M, GUERRANT, R. L, SEARS, C. L

“…To examine the transmission of Cryptosporidium infection in households with an identified person with cryptosporidiosis. Prospective cohort study. An urban…”
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Molecular physiology and pathophysiology of tight junctions V. assault of the tight junction by enteric pathogens by Sears, C L

“…Studies of the impact of enteric pathogens and their virulence factors on the proteins comprising the tight junction and zonula adherens offer a novel approach…”
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