Search Results - "Sears, Avery E."

Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle by Sears, Avery E, Palczewski, Krzysztof

“…Lecithin:retinol acyltransferase (LRAT) catalyzes the acyl transfer from the sn-1 position of phosphatidylcholine (PC) to all-trans-retinol, creating fatty…”
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Genome editing in the treatment of ocular diseases by Choi, Elliot H., Suh, Susie, Sears, Avery E., Hołubowicz, Rafał, Kedhar, Sanjay R., Browne, Andrew W., Palczewski, Krzysztof

“…Genome-editing technologies have ushered in a new era in gene therapy, providing novel therapeutic strategies for a wide range of diseases, including both…”
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LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3 by Golczak, Marcin, Sears, Avery E, Kiser, Philip D, Palczewski, Krzysztof

“…A crystal structure of a chimera composed of lipid-metabolizing transmembrane enzymes HRASLS3 and LRAT (which catalyzes esterification of vitamin A) identifies…”
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Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition by Sander, Christopher L, Sears, Avery E, Pinto, Antonio F M, Choi, Elliot H, Kahremany, Shirin, Gao, Fangyuan, Salom, David, Jin, Hui, Pardon, Els, Suh, Susie, Dong, Zhiqian, Steyaert, Jan, Saghatelian, Alan, Skowronska-Krawczyk, Dorota, Kiser, Philip D, Palczewski, Krzysztof

“…Photoreceptors rely on distinct membrane compartments to support their specialized function. Unlike protein localization, identification of critical…”
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Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins by Golczak, Marcin, Kiser, Philip D., Sears, Avery E., Lodowski, David T., Blaner, William S., Palczewski, Krzysztof

“…Lecithin:retinol acyltransferase-like proteins, also referred to as HRAS-like tumor suppressors, comprise a vertebrate subfamily of papain-like or NlpC/P60…”
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Single particle cryo‐EM of the complex between interphotoreceptor retinoid‐binding protein and a monoclonal antibody by Sears, Avery E., Albiez, Stefan, Gulati, Sahil, Wang, Benlian, Kiser, Philip, Kovacik, Lubomir, Engel, Andreas, Stahlberg, Henning, Palczewski, Krzysztof

“…Interphotoreceptor retinoid‐binding protein (IRBP) is a highly expressed protein secreted by rod and cone photoreceptors that has major roles in photoreceptor…”
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Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles by Sun, Da, Schur, Rebecca M., Sears, Avery E., Gao, Song-Qi, Vaidya, Amita, Sun, Wenyu, Maeda, Akiko, Kern, Timothy, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Stargardt disease (STGD) is an autosomal recessive retinal disorder caused by a monogenic ABCA4 mutation. Currently, there is no effective therapy to cure…”
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Coats Plus Syndrome in a Premature Infant, With a Focus on Management by Sears, Avery E., Awh, Caroline C., Kunhiabdullah, Shafeeque, Sears, Jonathan E., Mammo, Danny A.

“…Purpose: A premature infant was diagnosed with Coats plus syndrome based on a genetic evaluation showing biallelic heterozygous pathogenic CTC1 variants…”
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Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness by Sears, Avery E, Bernstein, Paul S, Cideciyan, Artur V, Hoyng, Carel, Charbel Issa, Peter, Palczewski, Krzysztof, Rosenfeld, Philip J, Sadda, SriniVas, Schraermeyer, Ulrich, Sparrow, Janet R, Washington, Ilyas, Scholl, Hendrik P N

“…Accumulation of fluorescent metabolic byproducts of the visual (retinoid) cycle is associated with photoreceptor and retinal pigment epithelial cell death in…”
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Two-photon imaging of the mammalian retina with ultrafast pulsing laser by Palczewska, Grazyna, Stremplewski, Patrycjusz, Suh, Susie, Alexander, Nathan, Salom, David, Dong, Zhiqian, Ruminski, Daniel, Choi, Elliot H, Sears, Avery E, Kern, Timothy S, Wojtkowski, Maciej, Palczewski, Krzysztof

“…Noninvasive imaging of visual system components in vivo is critical for understanding the causal mechanisms of retinal diseases and for developing therapies…”
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Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium by Sun, Da, Schur, Rebecca M, Sears, Avery E, Gao, Song-Qi, Sun, Wenyu, Naderi, Amirreza, Kern, Timothy, Palczewski, Krzysztof, Lu, Zheng-Rong

“…Dysfunctions caused by gene mutations in the retinal pigment epithelium (RPE) lead to retinal degeneration, visual function loss, and even blindness…”
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LRAT-specific domain facilitates Vitamin A metabolism by domain swapping in HRASLS by Golczak, Marcin, Sears, Avery E., Kiser, Philip D., Palczewski, Krzysztof

“…Cellular uptake of vitamin A, production of visual chromophore, and triglyceride homeostasis in adipocytes depend on two representatives of the vertebrate…”
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Cryo-Electron Microscopy Single-Particle Analysis of Interphotoreceptor Retinoid-Binding Protein and the Peripherin/ROM1 Complex, Proteins Necessary for the Sensation of Vision by Sears, Avery E

“…High-resolution structure determination is the necessary for understanding how protein fold affects function. Although x-ray crystallization is the…”
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