Search Results - "Searle, Peter"

Ontogenetic shape trajectory of Trichomycterus areolatus varies in response to water velocity environment by Searle, Peter C, Mercer, Margaret, Habit, Evelyn, Belk, Mark C

“…Body and head shape among fishes both vary between environments influenced by water velocity and across ontogeny. Although the shape changes associated with…”
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Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954 by Day, Martin A, Christofferson, Andrew J, Anderson, J L Ross, Vass, Simon O, Evans, Adam, Searle, Peter F, White, Scott A, Hyde, Eva I

“…NfsB has been studied extensively for its potential for cancer gene therapy by reducing the prodrug CB1954 to a cytotoxic derivative. We have previously made…”
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Using de novo transcriptomes to decipher the relationships in cutthroat trout subspecies (Oncorhynchus clarkii) by Kokkonen, Andrea L., Searle, Peter C., Shiozawa, Dennis K., Evans, R. Paul

“…For almost 200 years, the taxonomy of cutthroat trout (Oncorhynchus clarkii), a salmonid native to Western North America, has been in flux as ichthyologists…”
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Oxygen‐insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate by Day, Martin A., Jarrom, David, Rajah, Navina, Searle, Peter F., Hyde, Eva I., White, Scott A.

“…Escherichia coli NfsA and NfsB are founding members of two flavoprotein families that catalyze the oxygen‐insensitive reduction of nitroaromatics and quinones…”
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Viral gene therapy strategies: from basic science to clinical application by Young, Lawrence S, Searle, Peter F, Onion, David, Mautner, Vivien

“…A major impediment to the successful application of gene therapy for the treatment of a range of diseases is not a paucity of therapeutic genes, but the lack…”
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The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism by White, Scott A., Christofferson, Andrew J., Grainger, Alastair I., Day, Martin A., Jarrom, David, Graziano, Antonio E., Searle, Peter F., Hyde, Eva I.

“…Nitroreductases activate nitroaromatic antibiotics and cancer prodrugs to cytotoxic hydroxylamines and reduce quinones to quinols. Using steady‐state and…”
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Phylogenetic relationships of three rockfish: Sebastes melanops, Sebastes ciliatus and Sebastes variabilis (Scorpaeniformes, Scorpaenidae) based on complete mitochondrial genome sequences by Searle, Peter, Kokkonen, Andrea, Campbell, Jillian, Shiozawa, Dennis, Belk, Mark, Evans, R.

“…We characterise the complete mitochondrial genomes (mitogenomes) of Black rockfish ( Sebastes melanops Girard, 1856; n = 1), Dark rockfish ( Sebastes ciliatus…”
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Heterochronic shift in gene expression leads to ontogenetic morphological divergence between two closely related polyploid species by Searle, Peter C., Shiozawa, Dennis K., Evans, R. Paul, Hill, Jonathon T., Suli, Arminda, Stark, Michael R., Belk, Mark C.

“…Heterochrony—alteration to the rate or timing of development—is an important mechanism of trait differentiation associated with speciation. Heterochrony may…”
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Species boundaries in the messy middle—A genome‐scale validation of species delimitation in a recently diverged lineage of coastal fog desert lichen fungi by Jorna, Jesse, Linde, Jackson B., Searle, Peter C., Jackson, Abigail C., Nielsen, Mary‐Elise, Nate, Madeleine S., Saxton, Natalie A., Grewe, Felix, Herrera‐Campos, María de los Angeles, Spjut, Richard W., Wu, Huini, Ho, Brian, Lumbsch, H. Thorsten, Leavitt, Steven D.

“…Species delimitation among closely related species is challenging because traditional phenotype‐based approaches, for example, using morphology, ecological, or…”
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Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses by Rojas, Juan J, Guedan, Sonia, Searle, Peter F, Martinez-Quintanilla, Jordi, Gil-Hoyos, Raúl, Alcayaga-Miranda, Francisca, Cascallo, Manel, Alemany, Ramon

“…Oncolytic adenoviruses are promising anticancer agents due to their ability to self-amplify at the tumor mass. However, tumor stroma imposes barriers difficult…”
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Complete mitochondrial genomes of two rockfish: Sebastes maliger and Sebastes norvegicus (Scorpaenidae, Scorpaeniformes) by Campbell, Jillian R., Searle, Peter C., Kokkonen, Andrea L., Shiozawa, Dennis K., Belk, Mark C., Evans, R. Paul

“…We report the complete mitochondrial genomes of two rockfish: Sebastes maliger and Sebastes norvegicus. The mitogenomes consist of 13 protein-coding regions,…”
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A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984 by Patel, Prashant, Young, J Graham, Mautner, Vivien, Ashdown, Daniel, Bonney, Sarah, Pineda, Robert G, Collins, Stuart I, Searle, Peter F, Hull, Diana, Peers, Elizabeth, Chester, John, Wallace, D Michael, Doherty, Alan, Leung, Hing, Young, Lawrence S, James, Nicholas D

“…We report a phase I/II clinical trial in prostate cancer (PCa) using direct intraprostatic injection of a replication defective adenovirus vector (CTL102)…”
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A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984] by Patel, Prashant, Young, J Graham, Mautner, Vivien, Ashdown, Daniel, Bonney, Sarah, Pineda, Robert G, Collins, Stuart I, Searle, Peter F, Hull, Diana, Peers, Elizabeth, Chester, John, Wallace, D Michael, Doherty, Alan, Leung, Hing, Young, Lawrence S, James, Nicholas D

“…We report a phase I/II clinical trial in prostate cancer (PCa) using direct intraprostatic injection of a replication defective adenovirus vector (CTL102)…”
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Complete mitochondrial genomes of June sucker and Utah sucker (Chasmistes liorus and Catostomus ardens) by Searle, Peter C., Linde, Jackson B., Campbell, Jillian R., Kokkonen, Andrea L., Shiozawa, Dennis K., Belk, Mark C., Evans, R. Paul

“…The relationship between June sucker (Chasmistes liorus, Jordan, 1878) and Utah sucker (Catostomus ardens, Jordan & Gilbert, 1881) has been a matter of…”
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Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells by Habib-Agahi, Mojtaba, Phan, Thanh T., Searle, Peter F.

“…Activation of T cells requires co-stimulation, in addition to signals through the antigen–receptor complex. Antigen encounter without adequate co-stimulation…”
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Phylogenetic relationships of three rockfish: Sebastesmelanops , Sebastesciliatus and Sebastesvariabilis (Scorpaeniformes, Scorpaenidae) based on complete mitochondrial genome sequences by Searle, Peter C, Kokkonen, Andrea L, Campbell, Jillian R, Shiozawa, Dennis K, Belk, Mark C, Evans, R P

“…We characterise the complete mitochondrial genomes (mitogenomes) of Black rockfish ( Girard, 1856; n = 1), Dark rockfish ( Tilesius, 1813; n = 2) and Dusky…”
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Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme by Race, Paul R, Lovering, Andrew L, Green, Richard M, Ossor, Abdelmijd, White, Scott A, Searle, Peter F, Wrighton, Christopher J, Hyde, Eva I

“…The antibiotics nitrofurazone and nitrofurantoin are used in the treatment of genitourinary infections and as topical antibacterial agents. Their action is…”
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CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus by Elmetwali, Taha, Searle, Peter F, McNeish, Iain, Young, Lawrence S, Palmer, Daniel H

“…CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas…”
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Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12 by Dowell, Alexander C, Oldham, Kimberley A, Bhatt, Rupesh I, Lee, Steven P, Searle, Peter F

“…4-1BB ligation co-stimulates T cell activation, and agonistic antibodies have entered clinical trials. Natural killer (NK) cells also express 4-1BB following…”
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Human Leukocyte Antigen (HLA) A1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma by Zheng, Yong, Parsonage, Greg, Zhuang, Xiaodong, Machado, Lee R, James, Christine H, Salman, Asmaa, Searle, Peter F, Hui, Edwin P, Chan, Anthony T C, Lee, Steven P

“…Infusing virus-specific T cells is effective treatment for rare Epstein-Barr virus (EBV)-associated posttransplant lymphomas, and more limited success has been…”
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