Search Results - "Seara, Fernando A C"

Anthracycline-induced cardiotoxicity and cell senescence: new therapeutic option? by Seara, Fernando A. C., Kasai-Brunswick, Tais H., Nascimento, Jose H. M., Campos-de-Carvalho, Antonio C.

“…Anthracyclines are chemotherapeutic drugs widely used in the frontline of cancer treatment. The therapeutic mechanisms involve the stabilization of…”
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Cardiac ischemia/reperfusion injury is inversely affected by thyroid hormones excess or deficiency in male Wistar rats by Seara, Fernando A C, Maciel, Leonardo, Barbosa, Raiana A Q, Rodrigues, Nayana C, Silveira, Anderson L B, Marassi, Michelle P, Carvalho, Adriana B, Nascimento, José Hamilton M, Olivares, Emerson L

“…Thyroid dysfunctions can increase the risk of myocardial ischemia and infarction. However, the repercussions on cardiac ischemia/reperfusion (IR) injury remain…”
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Aging-related compensated hypogonadism: Role of metabolomic analysis in physiopathological and therapeutic evaluation by Monnerat, Gustavo, Seara, Fernando A.C., Evaristo, Joseph Albert Medeiros, Carneiro, Gabriel, Evaristo, Geisa Paulino Caprini, Domont, Gilberto, Nascimento, Jose Hamilton Matheus, Mill, Jose Geraldo, Nogueira, Fabio Cesar Souza, Campos de Carvalho, Antonio Carlos

“…[Display omitted] •Testosterone therapy, even in very low doses, promotes alteration in different metabolic pathways.•Testosterone therapy in old rats, but not…”
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Anabolic steroid excess and myocardial infarction: From ischemia to reperfusion injury by Seara, Fernando A.C., Olivares, Emerson L., Nascimento, Jose H.M.

“…Anabolic steroids (AS) are synthetic testosterone-derivatives developed by the pharmaceutical industry to mimic testosterone biological effects. So far, AS…”
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β-Arrestin–Biased Agonist Targeting the Brain AT1R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate–Salt Hypertension by Zanaty, Mario, Seara, Fernando A.C., Nakagawa, Pablo, Deng, Guorui, Mathieu, Natalia M., Balapattabi, Kirthikaa, Karnik, Sadashiva S., Grobe, Justin L., Sigmund, Curt D.

“…Activation of central AT1Rs (angiotensin type 1 receptors) is required for the increased blood pressure, polydipsia, and salt intake in deoxycorticosterone…”
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Pulmonary Circulation Under Pressure: Pathophysiological and Therapeutic Implications of BK Channel by Barenco-Marins, Thais S., Seara, Fernando A. C., Ponte, Cristiano G., Nascimento, Jose H. M.

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Mitochondrial dysfunction and cardiac ischemia/reperfusion injury are attenuated by nandrolone: Role of JAK-STAT3 pathway by Domingos, Ainá E., Seara, Fernando A.C., Oliveira, Dahienne F., Maciel, Leonardo, Barbosa, Raiana A.Q., Barcellos, Luciane C., Pinto, Verônica S., Fortunato, Rodrigo S., Nascimento, Jose H.M.

“…[Display omitted] •Acute nandrolone treatment decreased the susceptibility to cardiac IR injury;•Cardioprotection elicited by nandrolone is triggered by…”
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BKCa Channel Activation Attenuates the Pathophysiological Progression of Monocrotaline-Induced Pulmonary Arterial Hypertension in Wistar Rats by Ferraz, Ana Paula, Seara, Fernando A. C., Baptista, Emanuelle F., Barenco, Thais S., Sottani, Thais B. B., Souza, Natalia S. C., Domingos, Ainá E., Barbosa, Raiana A. Q., Takiya, Christina M., Couto, Marcos T., Resende, Gabriel O., Campos de Carvalho, Antonio C., Ponte, Cristiano G., Nascimento, Jose Hamilton M.

“…Purpose In the present study, the therapeutic efficacy of a selective BK Ca channel opener (compound X) in the treatment of monocrotaline (MCT)-induced…”
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Progression of heart failure is attenuated by antioxidant therapy with N-acetylcysteine in myocardial infarcted female rats by Costa, César R. M., Seara, Fernando A. C., Peixoto, Milena S., Ramos, Isalira P., Barbosa, Raiana A. Q., Carvalho, Adriana B., Fortunato, Rodrigo S., Silveira, Anderson L. B., Olivares, Emerson L.

“…This study investigated the therapeutic potential of N-acetylcysteine (NAC) in the treatment of heart failure in female rats. Myocardial infarcted (MI) rats…”
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Anabolic steroid excess promotes hydroelectrolytic and autonomic imbalance in adult male rats: Is it enough to alter blood pressure? by Seara, Fernando A.C., Pereira-Junior, Pedro P., Silva-Almeida, Claudio, Dos-Santos, Raoni C., Souza, Raquel N., Costa, César R.M., Domingos, Ainá E., Barbosa, Raiana A.Q., Ferraz, Ana P., Machado, André A.N., Ceccato, Vânia M., Takiya, Christina M., Ponte, Cristiano G., Reis, Luis C., Olivares, Emerson L., Nascimento, Jose H.M.

“…•AS excess elicited kidney hypertrophy and increased renal AT1R mRNA levels.•AS excess increased Na+/water retention, K+ excretion, and plasma…”
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Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats by Seara, Fernando A.C., Barbosa, Raiana A.Q., Santos, Marcus V.N., Domingos, Ainá E., Monnerat, Gustavo, Carvalho, Adriana B., Olivares, Emerson L., Mill, José G., Nascimento, Jose H.M., Campos de Carvalho, Antonio C.

“…•TST promoted cardiac hypertrophy in aged rats.•LV contractile function during IR was increased in aged rats treated with TST.•Infarct size of aged hearts was…”
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β-Arrestin Biased Agonist Targeting the Brain Angiotensin II Type 1 Receptor Increases Aversion to Saline and Lowers Blood Pressure in DOCA-salt Hypertension by Zanaty, Mario, Seara, Fernando A. C., Nakagawa, Pablo, Deng, Guorui, Mathieu, Natalia M., Balapattabi, Kirthikaa, Karnik, Sadashiva S., Grobe, Justin L., Sigmund, Curt D.

“…Activation of central angiotensin type 1 receptors (AT 1 R) is required for the increased blood pressure (BP), polydipsia and salt intake in…”
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β-Arrestin-Biased Agonist Targeting the Brain AT 1 R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension by Zanaty, Mario, Seara, Fernando A C, Nakagawa, Pablo, Deng, Guorui, Mathieu, Natalia M, Balapattabi, Kirthikaa, Karnik, Sadashiva S, Grobe, Justin L, Sigmund, Curt D

“…Activation of central AT Rs (angiotensin type 1 receptors) is required for the increased blood pressure, polydipsia, and salt intake in deoxycorticosterone…”
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Cardiac electrical and contractile disorders promoted by anabolic steroid overdose are associated with late autonomic imbalance and impaired Ca2+ handling by Seara, Fernando A.C., Arantes, Paulo C., Domingos, Ainá E., Barbosa, Raiana A.Q., Olivares, Emerson L., Sudo, Roberto T., Campos de Carvalho, Antonio C., Nascimento, Jose H.M.

“…•Nandrolone decanoate (DECA) promoted autonomic imbalance with decreased M2R mRNA expression.•QTc interval and cardiomyocyte action potential were prolonged by…”
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BK Ca Channel Activation Attenuates the Pathophysiological Progression of Monocrotaline-Induced Pulmonary Arterial Hypertension in Wistar Rats by Ferraz, Ana Paula, Seara, Fernando A C, Baptista, Emanuelle F, Barenco, Thais S, Sottani, Thais B B, Souza, Natalia S C, Domingos, Ainá E, Barbosa, Raiana A Q, Takiya, Christina M, Couto, Marcos T, Resende, Gabriel O, Campos de Carvalho, Antonio C, Ponte, Cristiano G, Nascimento, Jose Hamilton M

“…In the present study, the therapeutic efficacy of a selective BK channel opener (compound X) in the treatment of monocrotaline (MCT)-induced pulmonary arterial…”
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Cardiac electrical and contractile disorders promoted by anabolic steroid overdose are associated with late autonomic imbalance and impaired Ca 2+ handling by Seara, Fernando A C, Arantes, Paulo C, Domingos, Ainá E, Barbosa, Raiana A Q, Olivares, Emerson L, Sudo, Roberto T, Campos de Carvalho, Antonio C, Nascimento, Jose H M

“…Investigate cardiac electrical and mechanical dysfunctions elicited by chronic anabolic steroid (AS) overdose. Male Wistar rats were treated with nandrolone…”
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