Search Results - "Sear, J. W."

Kidney dysfunction in the postoperative period by Sear, J.W.

“…The development of perioperative acute renal failure is associated with a high incidence of morbidity and mortality. Although this incidence varies with…”
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Coronary artery stents and non-cardiac surgery by Howard-Alpe, G.M., de Bono, J., Hudsmith, L., Orr, W.P., Foex, P., Sear, J.W.

“…The utility of interventional cardiology has developed significantly over the last two decades with the introduction of coronary angioplasty and stenting, with…”
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Comparative molecular field analysis to derive pharmacophore maps for disposition parameters of intravenous anaesthetic agents by Sear, J.W.

“…The present study examines the molecular basis of the disposition kinetics for i.v. hypnotic agents using comparative molecular field analysis (CoMFA). The…”
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Hypertension, hypertensive heart disease and perioperative cardiac risk by Howell, S.J., Sear, J.W., Foëx, P

“…The evidence for an association between hypertensive disease, elevated admission arterial pressure, and perioperative cardiac outcome is reviewed. A systematic…”
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Comparative molecular field analysis to derive pharmacophore maps for induction doses of intravenous anaesthetic agents by Sear, J. W.

“…Background The present study examines the molecular basis of induction of anaesthesia by i.v. hypnotic agents using comparative molecular field analysis…”
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Meta-analysis of the effect of heart rate achieved by perioperative beta-adrenergic blockade on cardiovascular outcomes by Biccard, B.M., Sear, J.W., Foëx, P.

“…Acute perioperative beta-adrenergic blockade may be cardioprotective in the high-risk cardiac patient for major non-cardiac surgery. We have investigated the…”
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What makes a molecule an anaesthetic? Studies on the mechanisms of anaesthesia using a physicochemical approach by Sear, J.W.

“…Recent studies of mechanisms of anaesthesia have been mainly ‘target orientated’, investigating the activity of both volatile and i.v. agents at putative sites…”
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Development of pharmacophoric maps for cardiovascular depression by intravenous anaesthetic agents: comparison with maps for immobilizing activity by Sear, J.W.

“…The molecular basis of the cardiovascular effects of i.v. anaesthetics was investigated using comparative molecular field analysis (CoMFA). The cardiovascular…”
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Methods of detecting atherosclerosis in non-cardiac surgical patients; the role of biochemical markers by Howard-Alpe, G.M., Sear, J.W., Foex, P.

“…Atherosclerosis is a common condition in both the developed and developing world and is now recognised to be an inflammatory condition leading to the…”
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Statin therapy: a potentially useful peri‐operative intervention in patients with cardiovascular disease by Biccard, B. M., Sear, J. W., Foëx, P.

“…Summary Statin cardiovascular protection is mediated by lipid lowering and pleiotropic effects. The efficacy of statins has been established in non‐surgical…”
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PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration by ROBERTSON, S. A., LASCELLES, B. D. X., TAYLOR, P. M., SEAR, J. W.

“…The pharmacokinetics and thermal antinociceptive effects of buprenorphine after intravenous (i.v.) or oral transmucosal (OTM) administration were studied in…”
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Perioperative beta-blockade in non-cardiac surgical patients by Sear, J. W., Foex, P.

“…Not for everyone…”
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Effect of chronic β‐blockade on peri‐operative outcome in patients undergoing non‐cardiac surgery: an analysis of observational and case control studies by Giles, J. W., Sear, J. W., Foëx, P.

“…Summary Little is known about the effect of chronic β‐adrenoceptor antagonist therapy during the peri‐operative period in patients undergoing non‐cardiac…”
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Career choices for anaesthesia: national surveys of graduates of 1974–2002 from UK medical schools by Turner, G., Goldacre, M. J., Lambert, T., Sear, J. W.

“…Background. Knowledge about UK doctors' career intentions and pathways is essential for understanding future workforce requirements. The aim of this study was…”
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Systemic uptake of buprenorphine by cats after oral mucosal administration by Robertson, S. A., Taylor, P. M., Sear, J. W.

“…The plasma concentration of buprenorphine was measured by radioimmunoassay in six female cats after the administration of 0.01 mg/kg (0.033 ml/kg)…”
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Acute peri‐operative beta blockade in intermediate‐risk patients by Biccard, B. M., Sear, J. W., Foëx, P.

“…Summary Peri‐operative beta‐blockade has been shown to reduce the incidence of postoperative cardio‐ vascular complications including cardiac death in…”
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The pharmaco‐economics of peri‐operative statin therapy by Biccard, B. M., Sear, J. W., Foëx, P.

“…Summary We analysed the pharmaco‐economics of the prospective peri‐operative studies of statin administration for major elective vascular surgery, using the…”
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Use of a transdermal matrix patch of buprenorphine in cats: preliminary pharmacokinetic and pharmacodynamic data by Murrell, J. C., Robertson, S. A., Taylor, P. M., McCown, J. L., Bloomfield, M., Sear, J. W.

“…Six domestic shorthair cats, aged three to four years and weighing 5·1 to 7·4 kg, were used to assess the thermal antinociceptive effect of a transdermal…”
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Peri‐operative troponin I concentration as a marker of long‐term postoperative adverse cardiac outcomes – A study in high‐risk surgical patients by Higham, H., Sear, J. W., Sear, Y. M., Kemp, M., Hooper, R. J. L., Foex, P.

“…Summary We have previously demonstrated that the peri‐operative measurement of increased serum concentrations of the cardiac markers troponins I and T and…”
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Perioperative myocardial injury: individual and population implications by Howell, S.J., Sear, J.W.

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