Search Results - "Sear, J"

Kidney dysfunction in the postoperative period by Sear, J.W.

“…The development of perioperative acute renal failure is associated with a high incidence of morbidity and mortality. Although this incidence varies with…”
Get full text

Length of stay and mortality associated with healthcare-associated urinary tract infections: a multi-state model by Mitchell, B.G, Ferguson, J.K, Anderson, M, Sear, J, Barnett, A

“…Summary Background The emergence of antimicrobial resistance is of particular concern with respect to urinary tract infections, since the majority of causative…”
Get full text

Neuraxial block, death and serious cardiovascular morbidity in the POISE trial by Leslie, K., Myles, P., Devereaux, P., Williamson, E., Rao-Melancini, P., Forbes, A., Xu, S., Foex, P., Pogue, J., Arrieta, M., Bryson, G., Paul, J., Paech, M., Merchant, R., Choi, P., Badner, N., Peyton, P., Sear, J., Yang, H.

“…Background This post hoc analysis aimed to determine whether neuraxial block was associated with a composite of cardiovascular death, non-fatal myocardial…”
Get full text

Beta-blockade and other perioperative pharmacological protectors: what is now available and efficacious? by Sear, J.W., Higham, H., Foex, P.

Get full text

Coronary artery stents and non-cardiac surgery by Howard-Alpe, G.M., de Bono, J., Hudsmith, L., Orr, W.P., Foex, P., Sear, J.W.

“…The utility of interventional cardiology has developed significantly over the last two decades with the introduction of coronary angioplasty and stenting, with…”
Get full text

Comparative molecular field analysis to derive pharmacophore maps for disposition parameters of intravenous anaesthetic agents by Sear, J.W.

“…The present study examines the molecular basis of the disposition kinetics for i.v. hypnotic agents using comparative molecular field analysis (CoMFA). The…”
Get full text

Hypertension, hypertensive heart disease and perioperative cardiac risk by Howell, S.J., Sear, J.W., Foëx, P

“…The evidence for an association between hypertensive disease, elevated admission arterial pressure, and perioperative cardiac outcome is reviewed. A systematic…”
Get full text

Comparative molecular field analysis to derive pharmacophore maps for induction doses of intravenous anaesthetic agents by Sear, J. W.

“…Background The present study examines the molecular basis of induction of anaesthesia by i.v. hypnotic agents using comparative molecular field analysis…”
Get full text

Meta-analysis of the effect of heart rate achieved by perioperative beta-adrenergic blockade on cardiovascular outcomes by Biccard, B.M., Sear, J.W., Foëx, P.

“…Acute perioperative beta-adrenergic blockade may be cardioprotective in the high-risk cardiac patient for major non-cardiac surgery. We have investigated the…”
Get full text

PK-PD modeling of buprenorphine in cats: intravenous and oral transmucosal administration by ROBERTSON, S. A., LASCELLES, B. D. X., TAYLOR, P. M., SEAR, J. W.

“…The pharmacokinetics and thermal antinociceptive effects of buprenorphine after intravenous (i.v.) or oral transmucosal (OTM) administration were studied in…”
Get full text

What makes a molecule an anaesthetic? Studies on the mechanisms of anaesthesia using a physicochemical approach by Sear, J.W.

“…Recent studies of mechanisms of anaesthesia have been mainly ‘target orientated’, investigating the activity of both volatile and i.v. agents at putative sites…”
Get full text

Development of pharmacophoric maps for cardiovascular depression by intravenous anaesthetic agents: comparison with maps for immobilizing activity by Sear, J.W.

“…The molecular basis of the cardiovascular effects of i.v. anaesthetics was investigated using comparative molecular field analysis (CoMFA). The cardiovascular…”
Get full text

Methods of detecting atherosclerosis in non-cardiac surgical patients; the role of biochemical markers by Howard-Alpe, G.M., Sear, J.W., Foex, P.

“…Atherosclerosis is a common condition in both the developed and developing world and is now recognised to be an inflammatory condition leading to the…”
Get full text

Statin therapy: a potentially useful peri‐operative intervention in patients with cardiovascular disease by Biccard, B. M., Sear, J. W., Foëx, P.

“…Summary Statin cardiovascular protection is mediated by lipid lowering and pleiotropic effects. The efficacy of statins has been established in non‐surgical…”
Get full text

Perioperative beta-blockade, 2008: What does POISE tell us, and was our earlier caution justified? by Sear, J.W., Giles, J.W., Howard-Alpe, G., Foëx, P.

Get full text

Guidelines for preoperative cardiac risk assessment by Foex, P., Sear, J.W.

Get full text

Recommendations on perioperative β-blockers: differing guidelines: so what should the clinician do? by Sear, J.W., Foex, P.

Get full text

Perioperative beta-blockade in non-cardiac surgical patients by Sear, J. W., Foex, P.

“…Not for everyone…”
Get full text

Systemic uptake of buprenorphine by cats after oral mucosal administration by Robertson, S. A., Taylor, P. M., Sear, J. W.

“…The plasma concentration of buprenorphine was measured by radioimmunoassay in six female cats after the administration of 0.01 mg/kg (0.033 ml/kg)…”
Get full text

Comparison of tiletamine and zolazepam pharmacokinetics in tigers (Panthera tigris) and leopards (Panthera pardus): Do species differences account for adverse effects in tigers? by Lewis, J.C.M., Teale, P., Webber, G., Sear, J.W., Taylor, P.M.

“…Serious post-operative neurological complications of unknown aetiology are reported in tigers after immobilisation using tiletamine and zolazepam. These…”
Get full text