Search Results - "Sean McClory"
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HnRNP L represses cryptic exons
Published in RNA (Cambridge) (01-06-2018)“…The fidelity of RNA splicing is regulated by a network of splicing enhancers and repressors, although the rules that govern this process are not yet fully…”
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Journal Article -
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Reciprocal regulation of hnRNP C and CELF2 through translation and transcription tunes splicing activity in T cells
Published in Nucleic acids research (04-06-2020)“…RNA binding proteins (RBPs) frequently regulate the expression of other RBPs in mammalian cells. Such cross-regulation has been proposed to be important to…”
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In-cell SHAPE reveals that free 30S ribosome subunits are in the inactive state
Published in Proceedings of the National Academy of Sciences - PNAS (24-02-2015)“…It was shown decades ago that purified 30S ribosome subunits readily interconvert between “active” and “inactive” conformations in a switch that involves…”
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Distinct functional classes of ram mutations in 16S rRNA
Published in RNA (Cambridge) (01-04-2014)“…During decoding, the ribosome selects the correct (cognate) aminoacyl-tRNA (aa-tRNA) from a large pool of incorrect aa-tRNAs through a two-stage mechanism. In…”
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Missense suppressor mutations in 16S rRNA reveal the importance of helices h8 and h14 in aminoacyl-tRNA selection
Published in RNA (Cambridge) (01-10-2010)“…The molecular basis of the induced-fit mechanism that determines the fidelity of protein synthesis remains unclear. Here, we isolated mutations in 16S rRNA…”
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Ambulatory Arterial Stiffness Index as a Predictor of Cardiovascular Mortality in the Dublin Outcome Study
Published in Hypertension (Dallas, Tex. 1979) (01-03-2006)“…We hypothesized that the dynamic relation between diastolic and systolic blood pressure over 24 hours provides a measure of arterial stiffness and might,…”
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The human PMR1 endonuclease stimulates cell motility by down regulating miR-200 family microRNAs
Published in Nucleic acids research (08-07-2016)“…The motility of MCF-7 cells increases following expression of a human PMR1 transgene and the current study sought to identify the molecular basis for this…”
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Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study
Published in Hypertension (Dallas, Tex. 1979) (01-07-2005)“…The purpose of this study was to determine if ambulatory blood pressure measurement predicted total and cardiovascular mortality over and beyond clinic blood…”
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Insights into the Decoding Mechanism from Studies of Mutant Ribosomes
Published 01-01-2013“…In all cells, the 2.5 MDa, two-subunit complex known as the ribosome is responsible for translating each messenger RNA (mRNA) into a functional protein. To do…”
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Dissertation -
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Ambulatory blood pressure measurement as a predictor of outcome in an Irish population: methodology for ascertaining mortality outcome
Published in Blood pressure monitoring (01-08-2003)“…Ambulatory blood pressure monitoring (ABPM) has proven to be a superior predictor of morbid events when compared to clinic or office blood pressure measurement…”
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Journal Article