Search Results - "Seaman, Matthew"

The Retromer Complex: From Genesis to Revelations by Seaman, Matthew N.J.

“…The retromer complex has a well-established role in endosomal protein sorting, being necessary for maintaining the dynamic localisation of hundreds of membrane…”
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The retromer complex - endosomal protein recycling and beyond by Seaman, Matthew N J

“…The retromer complex is a vital element of the endosomal protein sorting machinery that is conserved across all eukaryotes. Retromer is most closely associated…”
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Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy by Zavodszky, Eszter, Seaman, Matthew N.J., Moreau, Kevin, Jimenez-Sanchez, Maria, Breusegem, Sophia Y., Harbour, Michael E., Rubinsztein, David C.

“…Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a…”
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Retromer-mediated endosomal protein sorting: all WASHed up by Seaman, Matthew N.J, Gautreau, Alexis, Billadeau, Daniel D

“…Highlights • Localised actin patches on endosomes define discrete domains to facilitate protein sorting. • Formation of branched actin on endosomes requires…”
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Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5 by Seaman, Matthew N.J, Harbour, Michael E, Tattersall, Daniel, Read, Eliot, Bright, Nicholas

“…Retromer is a membrane-associated heteropentameric coat complex that functions in the endosome-to-Golgi retrieval of the cation-independent mannose-6-phosphate…”
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The fifth adaptor protein complex by Hirst, Jennifer, Barlow, Lael D, Francisco, Gabriel Casey, Sahlender, Daniela A, Seaman, Matthew N J, Dacks, Joel B, Robinson, Margaret S

“…Adaptor protein (AP) complexes sort cargo into vesicles for transport from one membrane compartment of the cell to another. Four distinct AP complexes have…”
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Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval by Seaman, Matthew N.J

“…The cation-independent mannose 6-phosphate receptor (CIMPR) cycles between the trans-Golgi network (TGN) and endosomes to mediate sorting of lysosomal…”
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Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity by Randzavola, Lyra O, Strege, Katharina, Juzans, Marie, Asano, Yukako, Stinchcombe, Jane C, Gawden-Bone, Christian M, Seaman, Matthew Nj, Kuijpers, Taco W, Griffiths, Gillian M

“…CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating…”
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A dimmer switch for endosome-to-cell surface recycling by Seaman, Matthew N J

“…Endosome-to-cell surface recycling is mediated by retromer and Snx27. In this issue, Mao et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010048)…”
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Identification of Alzheimer disease-associated variants in genes that regulate retromer function by Vardarajan, Badri N, Bruesegem, Sophia Y, Harbour, Michael E, George-Hyslop, Peter St, Seaman, Matthew N.J, Farrer, Lindsay A

“…Abstract The proteolytic processing of amyloid precursor protein (APP) to generate the neurotoxic amyloid β (Aβ) peptide is central to the pathogenesis of…”
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An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome by Allison, Rachel, Lumb, Jennifer H, Fassier, Coralie, Connell, James W, Ten Martin, Daniel, Seaman, Matthew N J, Hazan, Jamilé, Reid, Evan

“…Mechanisms coordinating endosomal degradation and recycling are poorly understood, as are the cellular roles of microtubule (MT) severing. We show that cells…”
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Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35 by Harbour, Michael E, Breusegem, Sophia Y, Seaman, Matthew N J

“…The retromer complex is a conserved endosomal protein sorting complex that sorts membrane proteins into nascent endosomal tubules. The recognition of membrane…”
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Retromer and the cation‐independent mannose 6‐phosphate receptor—Time for a trial separation? by Seaman, Matthew N. J.

“…The retromer cargo‐selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome‐to‐Golgi retrieval of the cation‐independent mannose…”
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cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics by Harbour, Michael E, Breusegem, Sophia Y.A, Antrobus, Robin, Freeman, Caroline, Reid, Evan, Seaman, Matthew N.J

“…The retromer complex is required for the efficient endosome-to-Golgi retrieval of the CIMPR, sortilin, SORL1, wntless and other physiologically important…”
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A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling by Suzuki, Sho W, Chuang, Ya-Shan, Li, Ming, Seaman, Matthew N J, Emr, Scott D

“…Retromer is an evolutionarily conserved protein complex, which sorts functionally diverse membrane proteins into recycling tubules/vesicles from the endosome…”
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RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation by Freeman, Caroline L, Hesketh, Geoffrey, Seaman, Matthew N J

“…Retromer is a vital element of the endosomal protein sorting machinery and comprises two subcomplexes that operate together to sort membrane proteins (cargo)…”
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Cargo-Selective Endosomal Sorting for Retrieval to the Golgi Requires Retromer by Seaman, Matthew N J

“…Efndosome-to-Golgi retrieval of the mannose 6-phosphate receptor (MPR) is required for lysosome biogenesis. Currently, this pathway is poorly understood…”
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Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex by Seaman, Matthew N J, Mukadam, Aamir S, Breusegem, Sophia Y

“…The retromer complex is a vital component of the endosomal protein sorting machinery necessary for sorting into both the endosome-to-Golgi retrieval pathway…”
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Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment by Chibalina, Margarita V, Seaman, Matthew N.J, Miller, Christopher C, Kendrick-Jones, John, Buss, Folma

“…Myosin VI is an actin-based retrograde motor protein that plays a crucial role in both endocytic and secretory membrane trafficking pathways. Myosin VI's…”
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Back From the Brink: Retrieval of Membrane Proteins From Terminal Compartments: Unexpected Pathways for Membrane Protein Retrieval From Vacuoles and Endolysosomes by Seaman, Matthew N J

“…It has long been believed that membrane proteins present in degradative compartments such as endolysosomes or vacuoles would be destined for destruction. Now…”
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