Search Results - "Seal, Jon T."

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1 by Westaway, Susan M., Thompson, Mervyn, Rami, Harshad K., Stemp, Geoffrey, Trouw, Leontine S., Mitchell, Darren J., Seal, Jon T., Medhurst, Stephen J., Lappin, Sarah C., Biggs, James, Wright, James, Arpino, Sandra, Jerman, Jeffrey C., Cryan, Jennifer E., Holland, Vicky, Winborn, Kim Y., Coleman, Tanya, Stevens, Alexander J., Davis, John B., Gunthorpe, Martin J.

“…N-Quinolin-7-yl-6-phenylnicotinamide ( 2) was previously identified as a potent TRPV1 antagonist with activity in an in vivo model of inflammatory pain…”
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Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate by Westaway, Susan M, Brown, Samantha L, Fell, Stephen C. M, Johnson, Christopher N, MacPherson, David T, Mitchell, Darren J, Myatt, James W, Stanway, Steven J, Seal, Jon T, Stemp, Geoffrey, Thompson, Mervyn, Lawless, Kirk, McKay, Fiona, Muir, Alison I, Barford, Jonathan M, Cluff, Chermaine, Mahmood, Sadhia R, Matthews, Kim L, Mohamed, Shiyam, Smith, Beverley, Stevens, Alexander J, Bolton, Victoria J, Jarvie, Emma M, Sanger, Gareth J

“…N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine 12 (GSK962040) is a novel small molecule motilin receptor…”
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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists by AHMED, Mahmood, BRIGGS, Michael A, JOHNSON, Christopher N, MEDHURST, Andrew D, MITCHELL, Darren J, MOSS, Stephen F, POWLES, Jenifer, SEAL, Jon T, STEAN, Tania O, STEMP, Geoffrey, THOMPSON, Mervyn, TRAIL, Brenda, BROMIDGE, Steven M, UPTON, Neil, WINBORN, Kim, WITTY, David R, BUCK, Tania, CAMPBELL, Lorraine, DEEKS, Nigel J, GARNER, Ashley, GORDON, Laurie, HAMPRECHT, Dieter W, HOLLAND, Vicky

“…Starting from the potent and selective but poorly brain penetrant 5-HT6 receptor antagonist SB-271046, a successful strategy for improving brain penetration…”
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The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor by Westaway, Susan M., Brown, Samantha L., Conway, Elizabeth, Heightman, Tom D., Johnson, Christopher N., Lapsley, Kate, Macdonald, Gregor J., MacPherson, David T., Mitchell, Darren J., Myatt, James W., Seal, Jon T., Stanway, Steven J., Stemp, Geoffrey, Thompson, Mervyn, Celestini, Paolo, Colombo, Andrea, Consonni, Alessandra, Gagliardi, Stefania, Riccaboni, Mauro, Ronzoni, Silvano, Briggs, Michael A., Matthews, Kim L., Stevens, Alexander J., Bolton, Victoria J., Boyfield, Izzy, Jarvie, Emma M., Stratton, Sharon C., Sanger, Gareth J.

“…Optimisation of urea ( 5), identified from high throughput screening and subsequent array chemistry, has resulted in the identification of pyridine carboxamide…”
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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT 6 receptor antagonists by Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N., Medhurst, Andrew D., Mitchell, Darren J., Moss, Stephen F., Powles, Jenifer, Seal, Jon T., Stean, Tania O., Stemp, Geoffrey, Thompson, Mervyn, Trail, Brenda, Upton, Neil, Winborn, Kim, Witty, David R.

“…The selective, brain penetrant and orally bioavailable 5-HT 6 receptor antagonist 12 (699929) is described. Starting from the potent and selective but poorly…”
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Discovery of N-(3-Fluorophenyl)-1-[4-([(3S)-3-methyl-1-piperazinyl]methyl)phenylacetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate by WESTAWAY, Susan M, BROWN, Samantha L, THOMPSON, Mervyn, LAWLESS, Kirk, MCKAY, Fiona, MUIR, Alison I, BARFORD, Jonathan M, CLUFF, Chermaine, MAHMOOD, Sadhia R, MATTHEWS, Kim L, MOHAMED, Shiyam, SMITH, Beverley, FELL, Stephen C. M, STEVENS, Alexander J, BOLTON, Victoria J, JARVIE, Emma M, SANGER, Gareth J, JOHNSON, Christopher N, MACPHERSON, David T, MITCHELL, Darren J, MYATT, James W, STANWAY, Steven J, SEAL, Jon T, STEMP, Geoffrey

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WITHDRAWN: Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists by Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N., Medhurst, Andrew D., Mitchell, Darren J., Moss, Stephen F., Powles, Jenifer, Seal, Jon T., Stean, Tania O., Stemp, Geoffrey, Thompson, Mervyn, Trail, Brenda, Upton, Neil, Winborn, Kim, Witty, David R.

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