Search Results - "Seah, Geok Teng"

Strong Antibody Responses to Mycobacterium tuberculosis PE-PGRS62 Protein Are Associated with Latent and Active Tuberculosis by Koh, Kah Wee, Soh, Shu E, Seah, Geok Teng

“…Mycobacterium tuberculosis has a unique family of PE-PGRS proteins with conserved N-terminal domains (PE) containing site-specific proline-glutamine residues…”
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Interleukin-4 and Its Alternatively Spliced Variant (IL-4delta 2) in Patients with Atopic Asthma by SEAH, GEOK TENG, GAO, PEI SONG, HOPKIN, JULIAN M, ROOK, GRAHAM A. W

“…The interleukin-4 (IL-4) splice variant (IL-4delta2) is known to antagonize many biological activities of IL-4, and this challenges our understanding of the…”
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Regulatory T cells induced by Mycobacterium chelonae sensitization influence murine responses to bacille Calmette-Guérin by Ho, Peiying, Wei, Xing, Seah, Geok Teng

“…5CD4+CD25+ cells in Mycobacterium chelonae‐sensitized mice functionally suppress BCG‐induced inflammation, providing one explanation for how immune priming by…”
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Il-4 influences apoptosis of mycobacterium-reactive lymphocytes in the presence of TNF-alpha by Seah, G T, Rook, G A

“…T cell apoptosis is associated with defective cell-mediated effector functions in several infectious diseases. In tuberculosis, there is evidence that T cell…”
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Degradation-resistant protein domains limit host cell processing and immune detection of mycobacteria by Koh, Kah Wee, Lehming, Norbert, Seah, Geok Teng

“…The Mycobacterium tuberculosis genome reveals a large family of glycine–alanine rich PE–PGRS proteins. Due to similarities with the glycine–alanine rich…”
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IL-4 in tuberculosis: implications for vaccine design by Rook, Graham A.W., Hernandez-Pando, Rogelio, Dheda, Keertan, Teng Seah, Geok

“…Current attempts to find a vaccine for tuberculosis (TB) are based on the assumption that it must drive a Th1 response. We review the evidence that progressive…”
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Mycobacterium chelonae sensitisation induces CD4⁺-mediated cytotoxicity against BCG by Ho, Peiying, Zhang, Lin, Wei, Xing, Seah, Geok Teng

“…Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to…”
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Mycobacterium chelonae sensitisation induces CD4 super(+)-mediated cytotoxicity against BCG by Ho, Peiying, Zhang, Lin, Wei, Xing, Seah, Geok Teng

“…Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to…”
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High Levels of mRNA Encoding IL-4 in Unstimulated Peripheral Blood Mononuclear Cells from Tuberculosis Patients Revealed by Quantitative Nested Reverse Transcriptase-Polymerase Chain Reaction; Correlations with Serum IgE Levels by Geok Teng Seah, Graham A. W. Rook

“…The dominant view has been that there is little or no activation of Type 2 cytokine production in human tuberculosis. A novel approach to quantitative nested…”
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Tuberculosis associated with Mycobacterium tuberculosis Beijing and non-Beijing genotypes: a clinical and immunological comparison by Sun, Yong-Jiang, Lim, T K, Ong, Adrian Kheng Yeow, Ho, Benjamin Choon Heng, Seah, Geok Teng, Paton, Nicholas I

“…The Mycobacterium tuberculosis Beijing genotype is biologically different from other genotypes. We aimed to clinically and immunologically compare human…”
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Box 1. Why is assay of interleukin-4 (IL-4) so difficult? by Rook, Graham AW, Hernandez-Pando, Rogelio, Dheda, Keertan, Teng Seah, Geok

“…Current attempts to find a vaccine for tuberculosis (TB) are based on the assumption that it must drive a Th1 response. We review the evidence that progressive…”
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Tuberculosis associated with Mycobacterium tuberculosisBeijing and non-Beijing genotypes: a clinical and immunological comparison by Sun, Yong-Jiang, Lim, TK, Ong, Adrian Kheng Yeow, Ho, Benjamin Choon Heng, Seah, Geok Teng, Paton, Nicholas I

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Type-2 cytokines in the immunopathology of tuberculosis by Seah, Geok Teng

“…Immune correlates of protective and deleterious host responses in human tuberculosis are not well understood, but this knowledge is central to the design of…”
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IL-4 Influences Apoptosis of Mycobacterium-Reactive Lymphocytes in the Presence of TNF-{alpha} by Seah, Geok Teng, Rook, Graham A. W

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