Search Results - "Seachrist, D"

A review of the carcinogenic potential of bisphenol A by Seachrist, Darcie D., Bonk, Kristen W., Ho, Shuk-Mei, Prins, Gail S., Soto, Ana M., Keri, Ruth A.

“…The estrogenic properties of bisphenol A (BPA), a ubiquitous synthetic monomer that can leach into the food and water supply, have prompted considerable…”
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The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer by Seachrist, Darcie D, Keri, Ruth A

“…Activins and inhibins are closely related protein heterodimers with a similar tissue distribution; however, these two complexes have opposing functions in…”
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FOXA1: A Pioneer of Nuclear Receptor Action in Breast Cancer by Seachrist, Darcie D., Anstine, Lindsey J., Keri, Ruth A.

“…The pioneering function of FOXA1 establishes estrogen-responsive transcriptomes in luminal breast cancer. Dysregulated FOXA1 chromatin occupancy through focal…”
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KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene by Roberts, Melyssa S, Anstine, Lindsey J, Finke, Viviane S, Bryson, Benjamin L, Webb, Bryan M, Weber-Bonk, Kristen L, Seachrist, Darcie D, Majmudar, Parth R, Keri, Ruth A

“…Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted…”
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UbcH7 regulates 53BP1 stability and DSB repair by Han, Xiangzi, Zhang, Lei, Chung, Jinsil, Pozo, Franklin Mayca, Tran, Amanda, Seachrist, Darcie D., Jacobberger, James W., Keri, Ruth A., Gilmore, Hannah, Zhang, Youwei

“…DNA double-strand break (DSB) repair is not only key to genome stability but is also an important anticancer target. Through an shRNA library-based screening,…”
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Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer by Seachrist, Darcie D, Sizemore, Steven T, Johnson, Emhonta, Abdul-Karim, Fadi W, Weber Bonk, Kristen L, Keri, Ruth A

“…Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and…”
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Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors by Sahni, Jennifer M, Gayle, Sylvia S, Webb, Bryan M, Weber-Bonk, Kristen L, Seachrist, Darcie D, Singh, Salendra, Sizemore, Steven T, Restrepo, Nicole A, Bebek, Gurkan, Scacheri, Peter C, Varadan, Vinay, Summers, Matthew K, Keri, Ruth A

“…Triple-negative breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently recur, making the discovery of novel…”
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HER2/ErbB2-induced Breast Cancer Cell Migration and Invasion Require p120 Catenin Activation of Rac1 and Cdc42[S] by Johnson, Emhonta, Seachrist, Darcie D., DeLeon-Rodriguez, Carlos M., Lozada, Kristen L., Miedler, John, Abdul-Karim, Fadi W., Keri, Ruth A.

“…Breast cancers that overexpress the receptor tyrosine kinase ErbB2/HER2/Neu result in poor patient outcome because of extensive metastatic progression. Herein,…”
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Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression by YORI, Jennifer L, LOZADA, Kristen L, SEACHRIST, Darcie D, MOSLEY, Jonathan D, ABDUL-KARIM, Fadi W, BOOTH, Christine N, FLASK, Chris A, KERI, Ruth A

“…Resistance to receptor tyrosine kinase (RTK) blockade in breast cancer is often mediated by activation of bypass pathways that sustain growth. Src and…”
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LMO4 is an essential mediator of ErbB2 HER2 Neu-induced breast cancer cell cycle progression by Montañez-Wiscovich, M E, Seachrist, D D, Landis, M D, Visvader, J, Andersen, B, Keri, R A

“…ErbB2/HER2/Neu-overexpressing breast cancers are characterized by poor survival due to high proliferation and metastasis rates and identifying downstream…”
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Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice by LANDIS, Melissa D, SEACHRIST, Darcie D, MONTANEZ-WISCOVICH, Marjorie E, DANIELPOUR, David, KERI, Ruth A

“…Upregulation of HER2/ErbB2/Neu occurs in 15-30% of human breast cancers and correlates with poor prognosis. Identification of ErbB2/Neu transcriptional targets…”
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double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation by Peters, Gregory A, Seachrist, Darcie D, Keri, Ruth A, Sen, Ganes C

“…PACT is a double-stranded RNA-binding protein that also binds and activates the latent protein kinase, PKR, which plays a major role in cellular antiviral…”
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Krüppel-like Factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer by Yori, Jennifer L, Seachrist, Darcie D, Johnson, Emhonta, Lozada, Kristen L, Abdul-Karim, Fadi W, Chodosh, Lewis A, Schiemann, William P, Keri, Ruth A

“…Abstract Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that functions as an oncogene or tumor suppressor in a highly tissue-specific…”
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Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer by Mosley, Jonathan D, Poirier, John T, Seachrist, Darcie D, Landis, Melissa D, Keri, Ruth A

“…Amplification of the HER2 (ErbB2, c-Neu) proto-oncogene in breast cancer is associated with poor prognosis and high relapse rates. HER2/ErbB2, in conjunction…”
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Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2 Neu-induced tumors by LANDIS, M. D, SEACHRIST, D. D, ABDUL-KARIM, F. W, KERI, R. A

“…Epidemiological studies indicate that parity enhances HER2/ErbB2/Neu-induced breast tumorigenesis. Furthermore, recent studies using multiparous,…”
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Chromatin Organization and Transcriptional Programming of Breast Cancer Cell Identity by Bobbitt, Jessica R, Seachrist, Darcie D, Keri, Ruth A

“…Abstract The advent of sequencing technologies for assessing chromosome conformations has provided a wealth of information on the organization of the…”
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GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2) by Sizemore, Gina M., Sizemore, Steven T., Seachrist, Darcie D., Keri, Ruth A.

“…Breast cancer is a heterogeneous disease comprised of distinct subtypes predictive of patient outcome. Tumors of the basal-like subtype have a poor prognosis…”
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Reexpression of p8 Contributes to Tumorigenic Properties of Pituitary Cells and Appears in a Subset of Prolactinomas in Transgenic Mice that Hypersecrete Luteinizing Hormone by Mohammad, Helai P, Seachrist, Darcie D, Quirk, Christine C, Nilson, John H

“…Targeted overexpression of LH in transgenic mice causes hyperproliferation of Pit-1-positive pituitary cells and development of functional adenomas. To…”
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Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer by Milliken, E L, Lozada, K L, Johnson, E, Landis, M D, Seachrist, D D, Whitten, I, Sutton, A L M, Abdul-Karim, F W, Keri, R A

“…Aneuploidy and genomic instability are common features of human cancers, including breast cancer; however, mechanisms by which such abnormalities develop are…”
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TGF-β/activin signaling promotes CDK7 inhibitor resistance in triple-negative breast cancer cells through upregulation of multidrug transporters by Webb, Bryan M., Bryson, Benjamin L., Williams-Medina, Eduardo, Bobbitt, Jessica R., Seachrist, Darcie D., Anstine, Lindsey J., Keri, Ruth A.

“…Cyclin-dependent kinase 7 (CDK7) is a master regulatory kinase that drives cell cycle progression and stimulates expression of oncogenes in a myriad of…”
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