Search Results - "Seabrook, T."

The orbitofrontal cortex, food intake and obesity by Seabrook, Lauren T., Borgland, Stephanie L.

“…Obesity is a major health challenge facing many people throughout the world. Increased consumption of palatable, high-caloric foods is one of the major drivers…”
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Short- and Long-Term High-Fat Diet Exposure Differentially Alters Phasic and Tonic GABAergic Signaling onto Lateral Orbitofrontal Pyramidal Neurons by Seabrook, Lauren T, Peterson, Colleen S, Noble, Duncan, Sobey, Marissa, Tayyab, Temoor, Kenney, Tyra, Judge, Allap K, Armstrong, Mataea, Lin, Shihao, Borgland, Stephanie L

“…The chronic consumption of caloric dense high-fat foods is a major contributor to increased body weight, obesity, and other chronic health conditions. The…”
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Retinal input regulates the timing of corticogeniculate innervation by Seabrook, Tania A, El-Danaf, Rana N, Krahe, Thomas E, Fox, Michael A, Guido, William

“…Neurons in layer VI of visual cortex represent one of the largest sources of nonretinal input to the dorsal lateral geniculate nucleus (dLGN) and play a major…”
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Synaptic plasticity of the orbitofrontal cortex in obesity by Seabrook, Lauren T, Borgland, Stephanie L

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Characterization of white matter damage in animal models of multiple sclerosis by magnetization transfer ratio and quantitative mapping of the apparent bound proton fraction f by Rausch, M, Tofts, PS, Lervik, P, Walmsley, AR, Mir, A, Schubart, A, Seabrook, T

“…Quantitative magnetization transfer magnetic resonance imaging (qMT-MRI) can be used to improve detection of white matter tissue damage in multiple sclerosis…”
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Disinhibition of the orbitofrontal cortex biases decision-making in obesity by Seabrook, Lauren T., Naef, Lindsay, Baimel, Corey, Judge, Allap K., Kenney, Tyra, Ellis, Madelyn, Tayyab, Temoor, Armstrong, Mataea, Qiao, Min, Floresco, Stan B., Borgland, Stephanie L.

“…The lateral orbitofrontal cortex (lOFC) receives sensory information about food and integrates these signals with expected outcomes to guide future actions,…”
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Intracerebroventricular infusions of TNF-α preferentially recruit blood lymphocytes and induce a perivascular leukocyte infiltrate by Seabrook, T.J., Hay, J.B.

“…Tumour necrosis factor (TNF)-α is important in several central nervous system (CNS) inflammatory diseases, however, its role in the recruitment of leukocytes…”
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Cerebral spinal fluid lymphocytes are part of the normal recirculating lymphocyte pool by Seabrook, T.J., Johnston, M., Hay, J.B.

“…We have investigated the migration of lymphocytes from blood into the central nervous system (CNS) under normal physiological conditions. Using sheep as our…”
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Lymph, lymphocytes, and lymphatics by Ristevski, B, Becker, H, Cybulsky, M, Seabrook, T, Bak, S, Chan, E, Johnston, M, Hay, J B

“…This is a summary of recent developments regarding the role of the lymphatic system in immune responses. Emphasis is on physiological considerations from…”
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Splenectomy selectively affects the distribution and mobility of the recirculating lymphocyte pool by SEABROOK, T. J, HEIN, W. R, DUDLER, L, YOUNG, A. J

“…The spleen plays a major role in immune surveillance, but the impact that splenectomy exerts on the immune competence of an individual is not fully resolved…”
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The traffic of resting lymphocytes through delayed hypersensitivity and chronic inflammatory lesions: a dynamic equilibrium by Seabrook, T., Au, B., Dickstein, J., Zhang, X., Ristevski, B., Hay, J.B.

“…This essay is designed as a partial summary of the work of several students and colleagues from our laboratory. For the most part the experimental data have…”
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Complement C3 Deficiency Leads to Accelerated Amyloid {beta} Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice by Maier, Marcel, Peng, Ying, Jiang, Liying, Seabrook, Timothy J, Carroll, Michael C, Lemere, Cynthia A

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The use of the lipophilic fluorochrome CM-DiI for tracking the migration of lymphocytes by Andrade, William, Seabrook, Timothy J., Johnston, Miles G., Hay, John B.

“…In this study we examined the new cell dye CM-DiI for tracking the migration of lymphocytes from blood to lymph. This lipophilic marker intercalates in the…”
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Species-specific immune response to immunization with human versus rodent Aβ peptide by Seabrook, Timothy J, Bloom, Jeanne K, Iglesias, Melitza, Spooner, Edward T, Walsh, Dominic M, Lemere, Cynthia A

“…Amyloid beta (Aβ) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human Aβ induces humoral immunity, however, the immune response to…”
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Differences in the immune response to long term Aβ vaccination in C57BL/6 and B6D2F1 mice by Seabrook, Timothy J., Iglesias, Melitza, Bloom, Jeanne K., Spooner, Edward T., Lemere, Cynthia A.

“…The cerebral accumulation of β-amyloid (Aβ) is a pathological hallmark of Alzheimer’s disease (AD). Aβ vaccination or anti-Aβ specific antibodies may be a…”
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P.217Patterns of disease progression in patients with spinal muscular atrophy type 3 using the motor function measure by Seferian, A., Annoussamy, M., Chabanon, A., Cances, C., Goemans, N., Daron, A., Schara, U., Pereon, Y., Cuisset, J., El-Khairi, M., Seabrook, T., Vuillerot, C., Servais, L.

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P.353FIREFISH Part 1: 16-month safety and exploratory outcomes of risdiplam (RG7916) treatment in infants with type 1 spinal muscular atrophy by Baranello, G., Servais, L., Day, J., Deconinck, N., Mercuri, E., Klein, A., Darras, B., Masson, R., Kletzl, H., Cleary, Y., El-Khairi, M., Seabrook, T., Czech, C., Gerber, M., Nguyen, C., Gelblin, K., Gorni, K.

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Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions by Brana, Corinne, Frossard, Marie José, Pescini Gobert, Rosanna, Martinier, Nicolas, Boschert, Ursula, Seabrook, Timothy J.

“…Aims Sphingosine‐1‐phosphate receptor (S1PR) modulating therapies are currently in the clinic or undergoing investigation for multiple sclerosis (MS)…”
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Epinephrine causes a reduction in lymph node cell output in sheep by Seabrook, T J, Ristevski, B, Rhind, S G, Shek, P N, Zamecnik, J, Shephard, R J, Hay, J B

“…The lymphatic system has a critical role in the return of fluids, proteins, and cells to the circulatory system. However, the effects of stress, including…”
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SMA THERAPIES II AND BIOMARKERS by Baranello, G., Servais, L., Day, J., Deconinck, N., Mercuri, E., Klein, A., Darras, B., Masson, R., Kletzl, H., Cleary, Y., Armstrong, G., Seabrook, T., Czech, C., Gerber, M., Gelblin, K., Gorni, K., Khwaja, O.

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