Search Results - "Seabright, Alex P."

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner by Seabright, Alex P., Fine, Nicholas H. F., Barlow, Jonathan P., Lord, Samuel O., Musa, Ibrahim, Gray, Alexander, Bryant, Jack A., Banzhaf, Manuel, Lavery, Gareth G., Hardie, D. Grahame, Hodson, David J., Philp, Andrew, Lai, Yu‐Chiang

“…Mitophagy is a key process regulating mitochondrial quality control. Several mechanisms have been proposed to regulate mitophagy, but these have mostly been…”
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Regulatory Roles of PINK1-Parkin and AMPK in Ubiquitin-Dependent Skeletal Muscle Mitophagy by Seabright, Alex P, Lai, Yu-Chiang

“…The selective removal of damaged mitochondria, also known as mitophagy, is an important mechanism that regulates mitochondrial quality control. Evidence…”
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Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis by Webster, Justine M, Sagmeister, Michael S, Fenton, Chloe G, Seabright, Alex P, Lai, Yu-Chiang, Jones, Simon W, Filer, Andrew, Cooper, Mark S, Lavery, Gareth G, Raza, Karim, Langen, Ramon, Hardy, Rowan S

“…Glucocorticoids provide indispensable anti-inflammatory therapies. However, metabolic adverse effects including muscle wasting restrict their use. The enzyme…”
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No effect of five days of bed rest or short‐term resistance exercise prehabilitation on markers of skeletal muscle mitochondrial content and dynamics in older adults by Marshall, Ryan N., Smeuninx, Benoit, Seabright, Alex P., Morgan, Paul T., Atherton, Philip J., Philp, Andrew, Breen, Leigh

“…Bed rest (BR) results in significant impairments in skeletal muscle metabolism. Mitochondrial metabolism is reportedly highly sensitive to disuse, with…”
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The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth by Allen, Sophie L, Seabright, Alex P, Quinlan, Jonathan I, Dhaliwal, Amritpal, Williams, Felicity R, Fine, Nicholas H F, Hodson, David J, Armstrong, Matthew J, Elsharkaway, Ahmed M, Greig, Carolyn A, Lai, Yu-Chiang, Lord, Janet M, Lavery, Gareth G, Breen, Leigh

“…Sarcopenia is a common complication affecting liver disease patients, yet the underlying mechanisms remain unclear. We aimed to elucidate the cellular…”
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Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise by McIlvenna, Luke C, Parker, Hannah-Jade, Seabright, Alex P, Sale, Benedict, Anghileri, Genevieve, Weaver, Samuel R C, Lucas, Samuel J E, Whitham, Martin

“…Small extracellular vesicles (sEVs) are released from all cell types and participate in the intercellular exchange of proteins, lipids, metabolites and nucleic…”
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Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion by Podlogar, Tim, Shad, Brandon J, Seabright, Alex P, Odell, Oliver J, Lord, Samuel O, Civil, Rita, Salgueiro, Rafael B, Shepherd, Emma L, Lalor, Patricia F, Elhassan, Yasir S, Lai, Yu-Chiang, Rowlands, David S, Wallis, Gareth A

“…Ingested galactose can enhance postexercise liver glycogen repletion when combined with glucose but effects on muscle glycogen synthesis are unknown. In this…”
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