Search Results - "Seabra, Sérgio H"

In vitro anti-Leishmania activity of new isomeric cobalt(II)complexes and in silico insights: Mitochondria impairment and apoptosis-like cell death of the parasite by Rocha, Samuel M., Horn Jr, Adolfo, R. de M. L. Terra, Aline, Rezende, Lara M., Moreira, Felipe F., DaMatta, Renato A., Xavier, Fernando R., Cervo, Rodrigo, Cargnelutti, Roberta, Moorkkannur, Sreerag N., Owenby, Graysen, Prabhakar, Rajeev, Seabra, Sérgio H., Fernandes, Christiane

“…The synthesis, physico-chemical characterization and in vitro antiproliferative activity against the promastigote form of Leishmania amazonensis of two new…”
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Antileishmanial Efficacy of the Calpain Inhibitor MDL28170 in Combination with Amphotericin B by Branquinha, Marta H, Araújo, Pedro S S, Oliveira, Simone S C, Sangenito, Leandro S, Gonçalves, Diego S, Seabra, Sérgio H, d'Avila-Levy, Claudia M, Santos, André L S

“…The necessity of drug combinations to treat leishmaniasis came to the surface mainly because of the toxicity of current treatments and the emergence of…”
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A new iron(III) complex-containing sulfadiazine inhibits the proliferation and induces cystogenesis of Toxoplasma gondii by Portes, Juliana de A., Azeredo, Nathália F. B., Siqueira, Pedro G. T., de Souza, Tatiana Guinancio, Fernandes, Christiane, Horn, Adolfo, Candela, Dalber R. S., de Souza, Wanderley, DaMatta, Renato A., Seabra, Sérgio H.

“…We have previously shown that metallocomplexes can control the growth of Toxoplasma gondii , the agent that causes toxoplasmosis. In order to develop new…”
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Phosphatidylserine Exposure and Surface Sugars in Two Leishmania (Viannia) braziliensis Strains Involved in Cutaneous and Mucocutaneous Leishmaniasis by Farias, Luis Henrique S., Rodrigues, Ana Paula D., Silveira, Fernando T., Seabra, Sérgio H., DaMatta, Renato A., Saraiva, Elvira M., Silva, Edilene O.

“…Background. Phosphatidylserine (PS) and surface carbohydrates (SC) are known as virulence factors that may contribute to the different clinical symptoms…”
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Attachment of flagellum to the cell body is important to the kinetics of transferrin uptake by Trypanosoma cruzi by Rocha, Gustavo Miranda, Seabra, Sérgio H, de Miranda, Kildare Rocha, Cunha-e-Silva, Narcisa, de Carvalho, Tecia Maria Ulisses, de Souza, Wanderley

“…Abstract The flagellar pocket and the cytostome are surface domains of Trypanosoma cruzi epimastigote involved in acquisition of nutrients. The cytostome is…”
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Caspase-8 Activity Prevents Type 2 Cytokine Responses and Is Required for Protective T Cell-Mediated Immunity against Trypanosoma cruzi Infection by Silva, Elisabeth M, Guillermo, Landi V. C, Ribeiro-Gomes, Flavia L, De Meis, Juliana, Pereira, Renata M. S, Wu, Zhengqi, Calegari-Silva, Teresa C, Seabra, Sergio H, Lopes, Ulisses G, Siegel, Richard M, DosReis, George A, Lopes, Marcela F

“…During Trypanosoma cruzi infection, T cells up-regulate caspase-8 activity. To assess the role of caspase-8 in T cell-mediated immunity, we investigated the…”
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Development, structural, spectroscopic and in silico investigation of new complexes relevant as anti-toxoplasma metallopharmacs by Cardoso, Ana Paula, Madureira, Letícia M.P., Segat, Bruna B., Menezes, Jennifer do N.C., Cargnelutti, Roberta, Candela, Dalber R.S., Mariano, Davor L., Parreira, Renato L.T., Horn, Adolfo, Seabra, Sérgio H., DaMatta, Renato A., Moreira, Felipe F., Moreira, Renata V., Caramori, Giovanni F., Fernandes, Christiane

“…•Synthesis and characterization of Cu(II), Fe(III) and Zn(II) complexes.•Effective coordination of the pharmac to only one complex, the Zn(II)…”
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Extracellular vesicles and vesicle-free secretome of the protozoa Acanthamoeba castellanii under homeostasis and nutritional stress and their damaging potential to host cells by Gonçalves, Diego de Souza, Ferreira, Marina da Silva, Liedke, Susie Coutinho, Gomes, Kamilla Xavier, de Oliveira, Gabriel Afonso, Leão, Pedro Ernesto Lopes, Cesar, Gabriele Vargas, Seabra, Sergio H., Cortines, Juliana Reis, Casadevall, Arturo, Nimrichter, Leonardo, Domont, Gilberto Barbosa, Junqueira, Magno Rodrigues, Peralta, Jose Mauro, Guimaraes, Allan J.

“…Acanthamoeba castellanii (Ac) are ubiquitously distributed in nature, and by contaminating medical devices such as heart valves and contact lenses, they cause…”
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The calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotes by Marinho, Fernanda A, Gonçalves, Keyla C S, Oliveira, Simone S C, Gonçalves, Diego S, Matteoli, Filipe P, Seabra, Sergio H, Oliveira, Ana Carolina S, Bellio, Maria, Oliveira, Selma S, Souto-Padrón, Thaïs, d'Avila-Levy, Claudia M, Santos, André L S, Branquinha, Marta H

“…Human cutaneous leishmaniasis is caused by distinct species, including Leishmania amazonensis. Treatment of cutaneous leishmaniasis is far from satisfactory…”
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Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction by Granato, Marcela Q., Sousa, Ingrid S., Rosa, Thabatta L. S. A., Gonçalves, Diego S., Seabra, Sergio H., Alviano, Daniela S., Pessolani, Maria C. V., Santos, André L. S., Kneipp, Lucimar F.

“…Phialophora verrucosa causes several fungal human diseases, mainly chromoblastomycosis, which is extremely difficult to treat. Several studies have shown that…”
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Melanin in Fonsecaea pedrosoi: a trap for oxidative radicals by Cunha, Marcel M L, Franzen, Anderson J, Seabra, Sergio H, Herbst, Marcelo H, Vugman, Ney V, Borba, Luana P, de Souza, Wanderley, Rozental, Sonia

“…The pathogenic fungus Fonsecaea pedrosoi constitutively produces the pigment melanin, an important virulence factor in fungi. Melanin is incorporated in the…”
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A pro-inflammatory profile of endothelial cell in Lonomia obliqua envenomation by Nascimento-Silva, Vany, Rodrigues da Silva, Genilson, Moraes, João Alfredo, Cyrino, Fátima Z., Seabra, Sérgio H., Bouskela, Eliete, Guimarães, Jorge Almeida, Barja-Fidalgo, Christina

“…Lonomia obliqua envenomation is characterized by intense local inflammatory reaction, which, dependent on the severity of the case, is followed by severe…”
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Deciphering the effects of nelfinavir and lopinavir on epimastigote forms of Trypanosoma cruzi by Sangenito, Leandro Stefano, de Guedes, Arthur A, Gonçalves, Diego S, Seabra, Sergio H, d'Avila-Levy, Claudia M, Santos, André L.S, Branquinha, Marta H

“…Graphical abstract Image 1…”
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Assessment of biofilm formation by Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans by Mello, Thaís P., Aor, Ana Carolina, Gonçalves, Diego S., Seabra, Sergio H., Branquinha, Marta H., Santos, André L. S.

“…Reported herein is the ability of Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans conidia to adhere, differentiate into…”
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Effect of 3-bromopyruvate and atovaquone on infection during in vitro interaction of Toxoplasma gondii and LLC-MK2 cells by de Lima, Loyze Paola O, Seabra, Sergio H, Carneiro, Henrique, Barbosa, Helene S

“…Toxoplasma gondii infection can be severe during pregnancy and in immunocompromised patients. Current therapies for toxoplasmosis are restricted to tachyzoites…”
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Surface, adhesiveness and virulence aspects of Candida haemulonii species complex by Ramos, Lívia S, Oliveira, Simone S C, Silva, Laura N, Granato, Marcela Q, Gonçalves, Diego S, Frases, Susana, Seabra, Sergio H, Macedo, Alexandre J, Kneipp, Lucimar F, Branquinha, Marta H, Santos, André L S

“…Abstract The emerging opportunistic pathogens comprising the Candida haemulonii complex (C. haemulonii [Ch], C. duobushaemulonii [Cd] and C. haemulonii var…”
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Characterization in vivo and in vitro of a strain of Leishmania (Viannia) shawi from the Amazon Region by Ramos, Patrícia K.S, Diniz, José A.P, Silva, Edilene O, Quaresma, Juarez A.S, Saraiva, Elvira M, Seabra, Sérgio H, Atella, Geórgia C, de Souza, Wanderley

“…Abstract The present study analyses complement resistance, cell surface carbohydrates expression, lipidic composition and morphology in vivo and in vitro , of…”
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Toxoplasma gondii Partially Inhibits Nitric Oxide Production of Activated Murine Macrophages by Seabra, Sergio H., de Souza, Wanderley, DaMatta, Renato A.

“…Seabra, S. H., de Souza, W., and DaMatta, R. A. 2001. Toxoplasma gondii Partially inhibits nitric oxide production of activated murine macrophages…”
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Anti-Escherichia coli activity of extracts from Schinus terebinthifolius fruits and leaves by da Silva, Jessica H S, Simas, Naomi K, Alviano, Celuta S, Alviano, Daniela S, Ventura, José A, de Lima, Eliandro J, Seabra, Sergio H, Kuster, Ricardo M

“…Ethanol extracts obtained from Schinus terebinthifolius Raddi fruits and leaves were active against Escherichia coli with MIC of 78 μg mL for both extracts…”
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The serine peptidase inhibitor TPCK induces several morphophysiological changes in the opportunistic fungal pathogen Candida parapsilosis sensu stricto by Gandra, Rafael M, Silva, Laura N, Souto, Xênia M, Sangenito, Leandro S, Cruz, Lucas P S, Braga-Silva, Lys A, Gonçalves, Diego S, Seabra, Sergio H, Branquinha, Marta H, Santos, André L S

“…Abstract Candida parapsilosis sensu stricto (C. parapsilosis) has emerged as the second/third commonest Candida species isolated from hospitals worldwide…”
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