Search Results - "Scudamore, Cheryl"

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread by Wong, Ping-Pui, Demircioglu, Fevzi, Ghazaly, Essam, Alrawashdeh, Wasfi, Stratford, Michael R.L., Scudamore, Cheryl L., Cereser, Biancastella, Crnogorac-Jurcevic, Tatjana, McDonald, Stuart, Elia, George, Hagemann, Thorsten, Kocher, Hemant M., Hodivala-Dilke, Kairbaan M.

“…Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing side effects, is a primary goal of cancer research. In mouse and human…”
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Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer by Ali, Khaled, Soond, Dalya R., Piñeiro, Roberto, Hagemann, Thorsten, Pearce, Wayne, Lim, Ee Lyn, Bouabe, Hicham, Scudamore, Cheryl L., Hancox, Timothy, Maecker, Heather, Friedman, Lori, Turner, Martin, Okkenhaug, Klaus, Vanhaesebroeck, Bart

“…The kinase PI(3)Kδ is shown to be required for the immunosuppressive function of regulatory T cells; inactivation of PI(3)Kδ in these cells leads to enhanced…”
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HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation by Kelsall, Ian R, McCrory, Elisha H, Xu, Yingqi, Scudamore, Cheryl L, Nanda, Sambit K, Mancebo‐Gamella, Paula, Wood, Nicola T, Knebel, Axel, Matthews, Stephen J, Cohen, Philip

“…HOIL‐1, a component of the linear ubiquitin chain assembly complex (LUBAC), ubiquitylates serine and threonine residues in proteins by esterification. Here, we…”
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Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different? by Petrova, Tsvetana, Bennett, Kyle, Nanda, Sambit, Strickson, Sam, Scudamore, Cheryl L, Prescott, Alan R, Cohen, Philip

“…The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in…”
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Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles by Elshorbagy, Amany K, Jernerén, Fredrik, Scudamore, Cheryl L, McMurray, Fiona, Cater, Heather, Hough, Tertius, Cox, Roger, Refsum, Helga

“…Although reduced glutathione (rGSH) is decreased in obese mice and humans, block of GSH synthesis by buthionine sulfoximine (BSO) results in a lean,…”
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Gadd45γ and Map3k4 Interactions Regulate Mouse Testis Determination via p38 MAPK-Mediated Control of Sry Expression by Warr, Nick, Carre, Gwenn-Aël, Siggers, Pam, Faleato, Jessica Vitos, Brixey, Rachel, Pope, Madeleine, Bogani, Debora, Childers, Melissa, Wells, Sara, Scudamore, Cheryl L., Tedesco, Marianna, del Barco Barrantes, Ivan, Nebreda, Angel R., Trainor, Paul A., Greenfield, Andy

“…Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of…”
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Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development by Tibarewal, Priyanka, Rathbone, Victoria, Constantinou, Georgia, Pearce, Wayne, Adil, Mahreen, Varyova, Zofia, Folkes, Lisa, Hampson, Alix, Classen, Gala Anastasia Electra, Alves, Adriana, Carvalho, Sara, Scudamore, Cheryl L, Vanhaesebroeck, Bart

“…PTEN is one of the most commonly inactivated tumour suppressor genes in sporadic cancer. Germline heterozygous PTEN gene alterations also underlie PTEN…”
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Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity by Alliouachene, Samira, Bilanges, Benoit, Chicanne, Gaëtan, Anderson, Karen E., Pearce, Wayne, Ali, Khaled, Valet, Colin, Posor, York, Low, Pei Ching, Chaussade, Claire, Scudamore, Cheryl L., Salamon, Rachel S., Backer, Jonathan M., Stephens, Len, Hawkins, Phill T., Payrastre, Bernard, Vanhaesebroeck, Bart

“…In contrast to the class I phosphoinositide 3-kinases (PI3Ks), the organismal roles of the kinase activity of the class II PI3Ks are less clear. Here, we…”
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A guide to post-mortem examination procedure in mouse models by Rodrigues, Alexandra, Beresford, Lynn, Scudamore, Cheryl L, Yon, Marianne

“…The main objective of a post mortem is to identify, at a macroscopic level, any anatomical features that characterise mutant or sick mice and to describe…”
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Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors by Kosti, Paris, Opzoomer, James W., Larios-Martinez, Karen I., Henley-Smith, Rhonda, Scudamore, Cheryl L., Okesola, Mary, Taher, Mustafa Y.M., Davies, David M., Muliaditan, Tamara, Larcombe-Young, Daniel, Woodman, Natalie, Gillett, Cheryl E., Thavaraj, Selvam, Maher, John, Arnold, James N.

“…Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid tumors has proven challenging, in large part because of the lack of…”
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Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation by Stark, Anne-Katrien, Davenport, Elizabeth C M, Patton, Daniel T, Scudamore, Cheryl L, Vanhaesebroeck, Bart, Veldhoen, Marc, Garden, Oliver A, Okkenhaug, Klaus

“…Class I PI3K enzymes are critical for the maintenance of effective immunity. In T cells, PI3Kα and PI3Kδ are activated by the TCR and costimulatory receptors,…”
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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism by Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart

“…Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The…”
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Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling by Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles, Vanhaesebroeck, Bart

“…Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early…”
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Triggered doxorubicin release in solid tumors from thermosensitive liposome‐peptide hybrids: Critical parameters and therapeutic efficacy by Al‐Ahmady, Zahraa S., Scudamore, Cheryl L., Kostarelos, Kostas

“…Temperature‐sensitive vesicles designed by inclusion of leucine zipper peptides within a lipid bilayer (Lp‐Peptide hybrids) encapsulating Doxorubicin (DOX)…”
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Pharmacological inhibition of FTO by McMurray, Fiona, Demetriades, Marina, Aik, WeiShen, Merkestein, Myrte, Kramer, Holger, Andrew, Daniel S, Scudamore, Cheryl L, Hough, Tertius A, Wells, Sara, Ashcroft, Frances M, McDonough, Michael A, Schofield, Christopher J, Cox, Roger D

“…In 2007, a genome wide association study identified a SNP in intron one of the gene encoding human FTO that was associated with increased body mass index…”
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Systemic silencing of PHD2 causes reversible immune regulatory dysfunction by Yamamoto, Atsushi, Hester, Joanna, Macklin, Philip S, Kawai, Kento, Uchiyama, Masateru, Biggs, Daniel, Bishop, Tammie, Bull, Katherine, Cheng, Xiaotong, Cawthorne, Eleanor, Coleman, Mathew L, Crockford, Tanya L, Davies, Ben, Dow, Lukas E, Goldin, Rob, Kranc, Kamil, Kudo, Hiromi, Lawson, Hannah, McAuliffe, James, Milward, Kate, Scudamore, Cheryl L, Soilleux, Elizabeth, Issa, Fadi, Ratcliffe, Peter J, Pugh, Chris W

“…Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs. Genetic interventions on HIF/PHD pathways reveal…”
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Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans by Castillo, Sandra D, Tzouanacou, Elena, Zaw-Thin, May, Berenjeno, Inma M, Parker, Victoria E R, Chivite, Iñigo, Milà-Guasch, Maria, Pearce, Wayne, Solomon, Isabelle, Angulo-Urarte, Ana, Figueiredo, Ana M, Dewhurst, Robert E, Knox, Rachel G, Clark, Graeme R, Scudamore, Cheryl L, Badar, Adam, Kalber, Tammy L, Foster, Julie, Stuckey, Daniel J, David, Anna L, Phillips, Wayne A, Lythgoe, Mark F, Wilson, Valerie, Semple, Robert K, Sebire, Neil J, Kinsler, Veronica A, Graupera, Mariona, Vanhaesebroeck, Bart

“…Venous malformations (VMs) are painful and deforming vascular lesions composed of dilated vascular channels, which are present from birth. Mutations in the TEK…”
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The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities by Herbert, Eleanor, Stewart, Michelle, Hutchison, Marie, Flenniken, Ann M, Qu, Dawei, Nutter, Lauryl M J, McKerlie, Colin, Hobson, Liane, Kick, Brenda, Lyons, Bonnie, Wiegand, Jean-Paul, Doty, Rosalinda, Aguilar-Pimentel, Juan Antonio, Hrabe de Angelis, Martin, Dickinson, Mary, Seavitt, John, White, Jacqueline K, Scudamore, Cheryl L, Wells, Sara

“…Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in group-housed adult male mice from C57BL/6N substrains. Clinical signs…”
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Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome by McIntyre, Rebecca E, Lakshminarasimhan Chavali, Pavithra, Ismail, Ozama, Carragher, Damian M, Sanchez-Andrade, Gabriela, Forment, Josep V, Fu, Beiyuan, Del Castillo Velasco-Herrera, Martin, Edwards, Andrew, van der Weyden, Louise, Yang, Fengtang, Ramirez-Solis, Ramiro, Estabel, Jeanne, Gallagher, Ferdia A, Logan, Darren W, Arends, Mark J, Tsang, Stephen H, Mahajan, Vinit B, Scudamore, Cheryl L, White, Jacqueline K, Jackson, Stephen P, Gergely, Fanni, Adams, David J

“…Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a highly conserved and ubiquitiously expressed centrosomal protein, has been…”
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Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice by Alliouachene, Samira, Bilanges, Benoit, Chaussade, Claire, Pearce, Wayne, Foukas, Lazaros C., Scudamore, Cheryl L., Moniz, Larissa S., Vanhaesebroeck, Bart

“…Aims/hypothesis While the class I phosphoinositide 3-kinases (PI3Ks) are well-documented positive regulators of metabolism, the involvement of class II PI3K…”
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