Search Results - "Scribner, A W"

Glucose‐6‐phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability by Leopold, Jane A., Cap, Andre, Scribner, Anne W., Stanton, Robert C., Loscalzo, Joseph

“…ABSTRACT The vascular endothelium compensates for oxidant stress by increasing the activity of antioxidant enzymes such as glucose‐6‐phophate dehydrogenase…”
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Glucose-6-Phosphate Dehydrogenase Overexpression Decreases Endothelial Cell Oxidant Stress and Increases Bioavailable Nitric Oxide by Leopold, Jane A, Zhang, Ying-Yi, Scribner, Anne W, Stanton, Robert C, Loscalzo, Joseph

“…OBJECTIVE—Glucose-6-phosphate dehydrogenase (G6PD), the principal source of NADPH, serves as an antioxidant enzyme to modulate the redox milieu and nitric…”
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Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide by Zai, A, Rudd, M A, Scribner, A W, Loscalzo, J

“…Since thiols can undergo nitrosation and the cell membrane is rich in thiol-containing proteins, we considered the possibility that membrane surface thiols may…”
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Glucose-6-phosphate Dehydrogenase Modulates Vascular Endothelial Growth Factor-mediated Angiogenesis by Leopold, Jane A., Walker, Jennifer, Scribner, Anne W., Voetsch, Barbara, Zhang, Ying-Yi, Loscalzo, Alexander J., Stanton, Robert C., Loscalzo, Joseph

“…Glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the pentose phosphate pathway, is the principal intracellular source of NADPH. NADPH is utilized…”
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Hypoxia Potentiates Nitric Oxide-mediated Apoptosis in Endothelial Cells via Peroxynitrite-induced Activation of Mitochondria-dependent and -independent Pathways by Walford, Geoffrey A., Moussignac, Rose-Laure, Scribner, Anne W., Loscalzo, Joseph, Leopold, Jane A.

“…Nitric oxide (NO·) at low concentrations is cytoprotective for endothelial cells; however, elevated concentrations of NO· (≥1 μmol/liter), as may be achieved…”
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Synthesis, estrogen receptor binding, and tissue distribution of [ 18F]fluorodoisynolic acids by Scribner, Andrew W., Jonson, Stephanie D., Welch, Michael J., Katzenellenbogen, John A.

“…Doisynolic acids, D-ring seco-steroids derived from alkaline fusion of estrones, are hormonal curiosities: Their binding affinity for the estrogen receptor is…”
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Derivatives of 4-styrylpyridines: Synthesis, estrogen receptor binding affinity, and photophysical properties by Haroutounian, Serkos A., Scribner, Andrew W., Katzenellenbogen, John A.

“…In order to develop novel ligands for the estrogen receptor (ER) that might have high binding affinity and fluorescence properties suitable for assaying ER…”
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The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress by Scribner, Anne Ward, Loscalzo, Joseph, Napoli, Claudio

“…Angiotensin-converting enzyme (ACE) inhibitors effectively interfere with the renin–angiotensin system and exert various beneficial actions on vascular…”
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Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition by Rudd, M A, Trolliet, M, Hope, S, Scribner, A W, Daumerie, G, Toolan, G, Cloutier, T, Loscalzo, J

“…Although recent evidence suggests that reduced nitric oxide (NO) production may be involved in salt-induced hypertension, the specific NO synthase (NOS)…”
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Prevention of Hypertension and Renal Dysfunction in Dahl Rats by α-Tocopherol by Forde, Patrick, Scribner, Anne Ward, Dial, Ravina, Loscalzo, Joseph, Trolliet, María R

“…Although hypertension is a risk factor for the development of end-stage renal disease, not all hypertensive patients progress to develop renal dysfunction. The…”
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1-Aryl-2-pyridyl-3,4-dihydronaphthalenes:  Photofluorogenic Ligands for the Estrogen Receptor by Scribner, Andrew W, Haroutounian, Serkos A, Carlson, Kathryn E, Katzenellenbogen, John A

“…Three 1,2-substituted-3,4-dihydronaphthalenes that are pyridine analogs of the antiestrogen desmethylnafoxidine were prepared and evaluated as fluorescent…”
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